CAS: 18664-39-6; 3-(4-Cyanophenyl)Acrylic Acid

该化合物是一种有机化合物,其特点是其丙基酸结构,具有一种丙基酸结构,并配有一种丙基苯基替代物,该化合物的特性是:一个附于一个碳酸(Europio COOH)的乙烯基(Euros=CH2)组和一个苯基环,在副位置上进一步用一个丙基酸组(EurioCN)替代;该环组的存在增强了它的再活性和极性,使其在各种化学应用中有用,包括作为有机合成的中间体和药物的开发中;该化合物一般在室温下是固体,在标准条件下可能具有溶性,在有机溶剂和中度稳定性等特性;其独特结构使得有可能在材料科学中应用,特别是在聚合物和染料的合成中,该化合物的再活性可以在各种化学反应中加以利用,包括迈克尔添加物和其他核素替代物.

英文名称3-(4-Cyanophenyl)Acrylic Acid
中文名称4-氨基-2-氯嘧啶
IUPAC名称(E)-3-(4-cyanophenyl)acrylic acid
其它别名3-(4-Cyanophenyl)Acrylic Acid; 4-Cyanocinnamic Acid; Cyanocinnamicacid; P-Cyanocinnamic Acid; 2-Propenoic Acid, 3-(4-Cyanophenyl)-; 3-(4-Cyanophenyl)Propenoic Acid
CAS编号18664-39-6
MFCD编号:MFCD00016845
EINECS号:242-484-8
分子式:C10H7NO2
分子量:173.17
产品CID: 951570
产品分类香精与香料 → 合成香料 → 芳香肉桂酸,酯及衍生物

相似结构搜索
InChIKey: USVZQKYCNGNRBV-UHFFFAOYSA-N
InChI=1S/C10H7NO2/c11-7-9-3-1-8(2-4-9)5-6-10(12)13/h1-6H,(H,12,13)/b6-5+…
计算化学: 氢键受体数3.0氢键供体数1.0可旋转键数2.0

MSDS等安全信息

GHS符号GHS07
警示词Warning
危险描述H317-H319
防范说明P280-P305+P351+P338
危险等级IRRITANT
危险品标志Xn
安全声明26-36/37/39
危险类别码36/37/38-22

上下游产品

CAS号42287-94-5 3-(4-氰基苯基)丙酸 | CAS号38628-51-2 4-(2-羧乙基)苯甲酸 | CAS号52116-83-3 3-(4-苯腈)丙烯酸甲酯 | CAS号619-65-8 对氰基苯甲酸

合成工艺路线路线简述

丙二酸,4-氰基苯甲醛置于哌啶体系中,用吡啶用作溶剂,以67%的收率获得4-氰基肉桂酸
参考文献:Novel Cinnamic Acid Derivatives As Antioxidant And Anticancer Agents: Design,Synthesis And Modeling Studies
标题:Novel Cinnamic Acid Derivatives As Antioxidant And Anticancer Agents: Design,Synthesis And Modeling Studies
摘要:肉桂酸已被鉴定为具有抗氧化,抗炎和细胞毒性特性的有趣化合物.在本研究中,简单的肉桂酸通过knoevenagel缩合反应合成,并评估了上述生物活性.化合物4Ii证明是最强效的lox抑制剂.苯基取代的酸显示出对大豆lox更好的抑制活性,必须注意的是,相对于化合物2I和1I,具有更高亲脂性值的化合物4I和3I活性较低.这些化合物在不同的抗氧化测试中显示出非常好的活性.这些衍生物的抗癌特性已通过其在ht-29,A-549,Oaw-42,Mda-Mb-231,Hela和mrc-5正常细胞系中的1/ic50抑制值进行评估.考虑到对细胞系的ic50值,除了化合物4Ii外,这些化合物显示出较低的抗癌活性.对肉桂酸衍生物4Ii进行了分子对接研究,发现其与我们实验生物结果一致.
Doi:10.3390/molecules19079655

海关参考信息

2901210000-乙烯
2901220000-丙烯
2902300000-甲苯
2902500000-苯乙烯
💡 提示：海关信息按照顺序优先匹配，如需确认的海关信息，请参考相关资料。
详情请参考：📖 海关编码查询和海关进出口税则

专利信息

专利号:US-9505733-B2
优先权日:2011-11-18
标题:Single step enantioselective process for the preparation of 3-substituted chiral phthalides
发明人：REDDY REKULA SANTOSH; NAGA CHITHANYA KIRAN INDUKURU; ARUMUGAM SUDALAI
权利人:COUNCIL SCIENT IND RES
摘要:The present invention discloses single step, highly enantioselective catalytic oxidative cyclization process for the synthesis of 3-substituted chiral phthalides. In particular, the invention discloses asymmetric synthesis of chiral phthalides via synergetic nitrile accelerated oxidative cyclization of o-cyano substituted aryl alkenes in high yield and enantiomeric excess (ee) in short reaction time. Also, disclosed herein is â€œone-potâ€? asymmetric synthesis of biologically important natural compounds having 3-substituted chiral phthalide structural framework in the molecule.

专利号:US-9938258-B2
优先权日:2012-11-29
标题:Substituted 2,3-dihydrobenzofuranyl compounds and uses thereof
发明人：BALOGLU ERKAN; SHECHTER SHARON; SHACHAM SHARON; MCCAULEY DILARA; SENAPEDIS WILLIAM; GOLAN GALI; KALID ORI
权利人:KARYOPHARM THERAPEUTICS INC
摘要:The invention generally relates to substituted 2,3-dihydrobenzofuranyl compounds, and more particularly to a compound represented by Structural Formula I: n nor a pharmaceutically acceptable salt thereof, wherein the variables are as defined and described herein. The invention also includes the synthesis and use of a compound of Structural Formula I, or a pharmaceutically acceptable salt or composition thereof, e.g., in the treatment of cancer (e.g., mantle cell lymphoma), and other diseases and disorders.

专利号:CN-114230519-B
优先权日:2021-12-06
标题:A class of pleuromutilin cinnamate compounds with anti-drug-resistant bacteria activity and synthesis method and application thereof

专利号:CN-114230519-A
优先权日:2021-12-06
标题:A class of pleuromutilin cinnamate compounds with anti-drug-resistant bacteria activity and its synthesis method and application