CAS: 178974-97-5; 2,4-Difluoro-3-Methoxybenzoic Acid

📜1,3-二氟苯置于正丁基锂,Propyllithium体系中,用 2-甲基四氢呋喃,正己烷,甲苯 用作溶剂,化学反应 42.0H,反应生成2,4-二氟-3-甲氧基苯甲酸
参考文献:1-环丙基-4-氧代-7-氟-8-甲氧基-1,4-二氢喹 啉-3-羧酸的合成方法
标题:1-环丙基-4-氧代-7-氟-8-甲氧基-1,4-二氢喹 啉-3-羧酸的合成方法
摘要:本发明公开了一种1-环丙基-4-氧代-7-氟-8-甲氧基-1,4-二氢喹啉-3-羧酸的合成方法,包括以下反应步骤:间二氟苯与有机锂试剂反应,得到的芳基锂中间体与硼酸酯反应,经淬灭,得到2,6-二氟苯硼酸及2,6-二氟苯硼酸酯,经氧化得到的2,6-二氟苯酚与甲基化试剂反应,得到的2,6-二氟苯甲醚与有机锂试剂反应,得到相应的芳基锂中间体与二氧化碳反应,得到的产物再与酰氯化试剂反应,得到2,4-二氟-3-甲氧基苯甲酰氯,然后经关环反应,水解反应等,得到1-环丙基-4-氧代-7-氟-8-甲氧基-1,4-二氢喹啉-3-羧酸.本发明具有原料易得,各步反应收率好,原子经济性高,适合工业化应用等优点.

专利信息

专利号:US-8946422-B2
优先权日:2005-07-27
标题:8-methoxy-9H-isothiazolo[5,4-B]quinoline-3,4-diones and related compounds as anti-infective agents
发明人：BRADBURY BARTON JAMES; WILES JASON ALLAN; WANG QIUPING; HASHIMOTO AKHIRO; LUCIEN EDLAINE; PAIS GODWIN CLARENCE GILROY; DESHPANDE MILIND; PUCCI MICHEAL JOHN; KIM HA YOUNG
权利人:BRADBURY BARTON JAMES; WILES JASON ALLAN; WANG QIUPING; HASHIMOTO AKHIRO; LUCIEN EDLAINE; PAIS GODWIN CLARENCE GILROY; DESHPANDE MILIND; PUCCI MICHEAL JOHN; KIM HA YOUNG; ACHILLION PHARMACEUTICALS INC
摘要:The invention provides compound and salts of Formula I and II, disclosed herein, which includes compounds of Formula A and Formula B: Such compounds possess useful antimicrobial activity. The variables R2, R3, R5, R6, R7, and R9 shown in Formula A and B are defined herein. Certain compounds of Formula I and Formula II disclosed herein are potent and/or selective inhibitors of bacterial DNA synthesis and bacterial replication. The invention also provides antimicrobial compositions, including pharmaceutical compositions, containing one or more compounds of Formula I or Formula II and one or more carriers, excipients, or diluents. Such compositions may contain a compound of Formula I or Formula II as the only active agent or may contain a combination of a compound of Formula I or Formula II and one or more other active agents. The invention also provides methods for treating microbial infections in animals.

专利号:CN-120136692-A
优先权日:2025-03-14
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专利号:CN-119528713-A
优先权日:2024-11-27
标题 :Synthesis method of nemonoxacin intermediate 2, 4-difluoro-3-methoxy-1-benzoic acid

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优先权日:2024-08-26
标题:Synthesis method of nemonoxacin key intermediate