专利号:US-4393241-A 优先权日:1982-02-01 标 题 :Synthesis of alkoxy and phenoxy substituted aryl sulfides 发明人:HANSON HARRY T; SAPP JR JOHN B 权利人:CELANESE CORP 摘要:Provided is a novel process for the synthesis of aryl sulfides substituted with an alkoxy or phenoxy substituent. The process comprises reacting an alkoxy or phenoxy substituted aromatic compound with a sulfur dihalide, preferably sulfur dichloride, in the presence of an alkali metal tetrafluoroborate catalyst, with the amount of said aromatic reactant compound preferably being sufficient to solvate the sulfur dichloride and catalyst sufficiently to allow the reaction to occur.
专利号:US-9802952-B2 优先权日:2013-07-15 标 题:Method and apparatus for the synthesis of dihydroartemisinin and artemisinin derivatives 发明人:KOPETZKI DANIEL; MCQUADE DAVID TYLER; SEEBERGER PETER H; GILMORE KERRY 权利人:MAX-PLANCK-GESELLSCHAFT ZUR FÖRDERUNG DER WSS E V; MAX-PLANK-GESELLSCHAFT ZUR FÖRDERUNG DER WSS E V 摘要:The present invention is directed to a method for continuous production of dihydroartemisinin and also artemisinin derivatives derived from dihydroartemisinin by using artemisinin or dihydroartemisinic acid (DHAA) as starting material as well as to a continuous flow reactor for producing dihydroartemisinin as well as the artemisinin derivatives. It was found that the reduction of artemisinin to dihydroartemisinin in a continuous process requires a special kind of reactor and a special combination of reagents comprising a hydride reducing agent, at least one activator such as an inorganic activator, at least one solid base, at least one aprotic solvent and at least one C 1 -C 5 alcohol.
专利号:US-5783577-A 优先权日:1995-09-15 标题 :Synthesis of quinazolinone libraries and derivatives thereof 发明人:HOUGHTEN RICHARD A; OSTRESH JOHN M 权利人:TREGA BIOSCIENCES INC 摘要:The present invention provides synthetic combinatorial libraries of organic compounds based on the quinazolinone ring.
专利号:US-6107508-A 优先权日:1998-04-03 标 题 :Convergent synthesis of α-aryl-β-ketonitriles 发明人:ZHOU JIACHENG; OH LYNETTE MAY; MA PHILIP 权利人:DU PONT PHARM CO 摘要:The present invention relates to processes for the production of alpha -aryl- beta -ketonitriles, which serve as synthetic intermediates in the preparation of a series of biologically important molecules such as corticotropin releasing factor (CRF) receptor antagonists.
专利号:US-7112679-B2 优先权日:1998-04-03 标题:Convergent synthesis of α-aryl-β-ketonitriles 发明人:ZHOU JIACHENG; OH LYNETTE MAY; MA PHILIP 权利人:BRISTOL MYERS SQUIBB PHARMA CO 摘要:The present invention relates to processes for the production of α-aryl-β-ketonitriles, which serve as synthetic intermediates in the preparation of a series of biologically important molecules such as corticotropin releasing factor (CRF) receptor antagonists.
专利号:US-10995078-B2 优先权日:2013-03-13 标 题:Compounds and compositions for inhibition of FASN 发明人:BAIR KENNETH W; LANCIA JR DAVID R; LI HONGBIN; LOCH JAMES; LU WEI; MARTIN MATTHEW W; MILLAN DAVID S; SCHILLER SHAWN E R; TEBBE MARK J 权利人:FORMA THERAPEUTICS INC 摘要:The present invention relates to compounds and composition for inhibition of FASN, their synthesis, applications, and antidotes. An illustrative compound of the invention is shown below:
[参考文献]: Manabu Nakazono, Et Al. Novel Styrylbenzene Derivatives For Detecting Amyloid Deposits. Clin Chim Acta. 2014 Sep 25:436:27-34.
合成参考文献
摘要:Stanforth, S. P., Science of Synthesis Knowledge Updates, (2015) 1, 207. 摘要:Nakao, Y., Science of Synthesis: Catalytic Transformations via CH Activation, (2015) 1, 397. 摘要:Fogel, M. S.; Shellnutt, Z. S.; Koide, K., Science of Synthesis: Dearomatizations, (2026) .