CAS: 166172-69-6; Bis[3,5-Bis(Trifluoromethyl)Phenyl]Phosphane

上下游产品

bis(3,5-di(trifluoromethyl)phenyl)chlorophosphine bis[3,5-bis(trifluoromethyl) phenyl]phosphine oxide 3,6-bis(trifluoromethyl)bromobenzene 22H20F12NPC22H20F12NPphosphino>methyl>-1,1'-biphenyl2,2'-bisphosphinomethyl-1,1'-biphenyl Bis-(3,5-bis-trifluoromethyl-phenyl)-vinyl-phosphane P,P'-(1,2-ethanediyl)bis{bis[3,5-di(trifluoromethyl)phenyl]phosphane} 3-[bis-(3,5-bis-trifluoromethyl-phenyl)-phosphanyl]-propan-1-ol

📜在 硼烷四氢呋喃络合物体系中,用 二氯甲烷 用作溶剂,化学反应 1.0H,反应生成双(3,5-二(三氟甲基)苯基)膦
参考文献:桦木还原过程中二芳基次膦酸-硼烷酰胺的非对映选择性脱对称†
标题:桦木还原过程中二芳基次膦酸-硼烷酰胺的非对映选择性脱对称†
摘要:用碱金属溶液在液氨中处理具有手性酰胺基官能团的二芳基次膦酸-硼烷酰胺会诱导一个芳基取代基在磷上优先脱芳香化,导致形成非等摩尔量的非对映异构体.脱芳香化的非对映选择性很大程度上取决于手性助剂的结构.
Doi:10.1039/c4Ob02440K

专利信息

专利号:US-12202782-B2
优先权日:2020-11-19
标 题:Processes and intermediates for preparing MCL1 inhibitors
发明人：DIXON DARRYL D; ISCHAY MICHAEL A; JOHNSON TREVOR C; MERIT JEFFREY E; REGENS CHRISTOPHER S; STANDLEY ERIC A; STEINHUEBEL DIETRICH P
权利人:GILEAD SCIENCES INC
摘要:The present disclosure relates to methods and intermediates for the synthesis of certain compounds that inhibit MCL1, for use in the treatment of cancers.

专利号:US-11780834-B2
优先权日:2018-06-21
标题:Solid forms of 3-((1R,3R)-1-(2,6-difluoro-4-((1-(3-fluoropropyl)azetidin-3- yl)amino)phenyl)-3-methyl-1,3,4,9-tetrahydro-2H-pyrido[3,4-b]indol-2-yl)-2,2-difluoropropan-1-ol and processes for preparing fused tricyclic compounds comprising a substituted phenyl or pyridinyl moiety, including methods of their use
发明人：CHUNG CHEOL KEUN; XU JIE; IDING HANS; CLAGG KYLE; DALZIEL MICHAEL; FETTES ALEC; GOSSELIN FRANCIS; LIM NGIAP-KIE; MCCLORY ANDREW; ZHANG HAIMING; CHAKRAVARTY PAROMA; NAGAPUDI KARTHIK; ROBINSON SARAH
权利人:HOFFMANN LA ROCHE; GENENTECH INC
摘要:Provided herein are solid forms, salts, and formulations of 3-((1R,3R)-1-(2,6-difluoro-4-((1-(3-fluoropropyl)azetidin-3-yl)amino)phenyl)-3-methyl-1,3,4,9-tetrahydro-2H-pyrido[3,4-b]indol-2-yl)-2,2-difluoropropan-1-ol, processes and synthesis thereof, and methods of their use in the treatment of cancer.

专利号:US-9062085-B2
优先权日:2010-09-10
标 题 :Biaryl diphosphine ligands, intermediates of the same and their use in asymmetric catalysis
发明人：ABDUR-RASHID KAMALUDDIN; JIA WENLI; LU SHUIMING; GUO RONGWEI; CHEN XUANHUA; AMOROSO DINO
权利人:ABDUR-RASHID KAMALUDDIN; JIA WENLI; LU SHUIMING; GUO RONGWEI; CHEN XUANHUA; AMOROSO DINO; KANATA CHEMICAL TECHNOLOGIES INC
摘要:The present disclosure relates to biaryl diphosphine ligands of the formula (B), processes for the production of the ligands and the use of the ligands in metal catalysts for asymmetric synthesis. The disclosure also relates to intermediates used for the production of the biaryl diphosphine ligand. (Formula (B))

专利号:US-9962690-B2
优先权日:2014-04-27
标题:N-substituted pyridiniophosphines, processes for their preparation and their use
发明人：ALCARAZO MANUEL; WILLE CHRISTIAN; TINNERMANN HENDRIK
权利人:STUDIENGESELLSCHAFT KOHLE MBH
摘要:The present invention deals with the synthesis and applications of new cationic compounds being useful as metal ligands. Specifically, N-alkyl/aryl substituted pyridiniophosphines are prepared and used as ligands for transition metals. The so-obtained metal complexes and their use as catalysts in chemical synthesis is also described. It also worth mentioning that N-alkyl/aryl pyridiniophosphines can be synthesized through a short, scalable and highly modular route.