CAS: 16595-80-5; Levamisole (Hydrochloride)

相似化合物

14769-73-4 5086-74-8 1173021-85-6

上下游产品

Tetramisole toluene LevamisoleLevamisole levamisole citrate levamisole L-ascorbate 1-(2-Mercapto-ethyl)-4-phenyl-imidazolidin-2-one(S)-3-(2'-hydroxy-2'-phenylethyl)-2-thiazolidinimine hydr°Chloride Tetramisole (S)-3-(2'-hydroxy-2'-phenylethyl)-2-thiazolidinimine (S)-2-Amino-1-phenyl-1-ethanolS,11aΞ)-1,3-di-naphthalen-1-yl-6-phenyl-tetrahydro-thiazolo[2',3':2,3]imidazo[1,2-a][1,3,5]triazine-2,4-dione(6S,11aΞ)-1,3-di-naphthalen-1-yl-6-phenyl-tetrahydro-thiazolo[2',3':2,3]imidazo[1,2-a][1,3,5]triazine-2,4-dione levamisole citrate levamisole L-ascorbate levamisole hydr°Chloride

左旋咪唑置于盐酸体系中,用 异丙醇,丙酮 用作溶剂,以78.5 %的收率获得盐酸左旋咪唑
参考文献:一种盐酸左旋咪唑的制备方法
标题:一种盐酸左旋咪唑的制备方法
摘要:本发明公开了一种盐酸左旋咪唑的制备方法,属于医药中间体技术领域.以(R)‑环氧苯乙烷为原料,与2‑氯乙胺盐酸盐在水中开环得到(R)‑1‑苯基‑2‑氨基乙醇;接着与硫脲关环得到(R)‑3‑(2'‑羟基‑2'‑苯乙基)‑2‑噻唑烷亚胺,最后分子内mitsunobu关环反应,处理后得到盐酸左旋咪唑.该制备方法反应步骤简短,操作简单且连贯,易于控制,对设备腐蚀性低,同时也提高产品的收率和品质.

专利信息

专利号:US-4314066-A
优先权日:1976-11-08
标题 :Synthesis of tetramisole, levamisole and their derivatives
发明人：RAGHU SIVARAMAN; HOFFMANN ARTHUR K; SINGH BALWANT
权利人:AMERICAN CYANAMID CO
摘要:A process for the manufacture of 1-(2-alkoxyethyl)-4-phenyl-4-imidazolin-2-ones, 1-(2-alkoxyethyl)-4-phenyl-2-imidazolidones, 1-(2-alkoxyethyl)-4-phenyl-imidazolidine-2-thiones, certain of the corresponding 1-(2-hydroxyethyl) derivatives, and their 3-acylated derivatives, and certain related compounds which are all useful as intermediates in a new process for the manufacture of the anthelmintic levamisole, (-)-2,3,5,6-tetrahydro-6-phenylimidazo-[2,1-b]thiazole, and its derivatives through conventional resolution procedures. The new process also permits the direct manufacture of optically active 1-(2-alkoxyethyl)-4-phenyl-2-imidazolidone and their 3-acylated derivatives, optically active 1-(2-alkoxyethyl)-4-phenylimidazolidine-2-thiones, and levamisole, the levorotatory isomer of tetramisole, using catalytic amounts of a chiral reducing agent, with the elimination of conventional resolution procedures.

专利号:US-4370482-A
优先权日:1978-02-15
标题:Synthesis of tetramisole, levamisole and their derivatives
发明人：RAGHU SIVARAMAN; HOFFMANN ARTHUR K; SINGH BALWANT
权利人:AMERICAN CYANAMID CO
摘要:A process for the manufacture of 1-(2-alkoxyethyl)-4-phenyl-4-imidazolin-2-ones, 1-(2-alkoxyethyl)-4-phenyl-2-imidazolidones, 1-(2-alkoxyethyl)-4-phenyl-imidazolidine-2-thiones, certain of the corresponding 1-(2-hydroxyethyl) derivatives, and their 3-acylated derivatives, and certain related compounds which are all useful as intermediates in a new process for the manufacture of the anthelmintic levamisole, (-)-2,3,5,6-tetrahydro-6-phenylimidazo-[2,1-b]thiazols, and its derivatives through conventional resolution procedures. The new process also permits the direct manufacture of optically active 1-(2-alkoxyethyl)-4-phenyl-2-imidazolidone and their 3-acylated derivatives, optically active 1-(2-alkoxyethyl)-4-phenylimidazolidine-2-thiones, and levamisole, the levorotatory isomer of tetramisole, using catalytic amounts of a chiral reducing agent, with the elimination of conventional resolution procedures.

专利号:US-4310672-A
优先权日:1976-04-26
标题 :Synthesis of intermediates for tetramisole, levamisole and their derivatives
发明人：RAGHU SIVARAMAN; HOFFMANN ARTHUR K; SINGH BALWANT
权利人:AMERICAN CYANAMID CO
摘要:A process for the manufacture of 1-(2-alkoxyethyl)-4-phenyl-4-imidazolin-2-ones, 1-(2-alkoxyethyl)-4-phenyl-2-imidazolidones, 1-(2-alkoxyethyl)-4-phenyl-imidazolidine-2-thiones, certain of the corresponding 1-(2-hydroxyethyl) derivatives and their 3-acylated derivatives, and certain related compounds which are all useful as intermediates in a new process for the manufacture of tetramisole, di-2,3,5,6-tetrahydro-6-phenylimidazo-[2,1-b]thiazole, and its derivatives. The compound tetramisole is useful as an anthelmintic.

专利号:US-4620009-A
优先权日:1980-03-17
标 题 :Synthesis of intermediates for tetramisole, levamisole and their derivatives
发明人：RAGHU SIVARAMAN; HOFFMANN ARTHUR K; SINGH BALWANT
权利人:CYANAMID AGRICULTURAL DE PUERT
摘要:A process for the manufacture of 1-(2-alkoxyethyl)-4-phenyl-4-imidazolin-2-ones, 1-(2-alkoxyethyl)-4-phenyl-2-imidazolidones, 1-(2-alkoxyethyl)-4-phenyl-imidazolidine-2-thiones, certain of the corresponding 1-(2-hydroxyethyl) derivatives and their 3-acylated derivatives, and certain related compounds which are all useful as intermediates in a new process for the manufacture of tetramisole, dl-2,3,5,6-tetrahydro-6-phenylimidazo-[2,1-b]thiazole, and its derivatives. The compound tetramisole is useful as an anthelmintic.

专利号:US-4139707-A
优先权日:1976-11-08
标题 :Intermediates for synthesis of tetramisole, levamisole and their derivatives
发明人：RAGHU SIVARAMAN; HOFFMANN ARTHUR K; SINGH BALWANT
权利人:AMERICAN CYANAMID CO
摘要:A process for the manufacture of 1-(2-alkoxyethyl)-4-phenyl-4-imidazolin-2-ones, 1-(2-alkoxyethyl)-4-phenyl-2-imidazolidones, 1-(2-alkoxyethyl)-4-phenyl-imidazolidine-2-thiones, certain of the corresponding 1-(2-hydroxyethyl) derivatives and their 3-acylated derivatives, and certain related compounds which are all useful as intermediates in a new process for the manufacture of tetramisole, dl-2,3,5,6-tetrahydro-6-phenylimidazo-[2,1-b]thiazole, and its derivatives. The compound tetramisole is useful as an anthelmintic.

专利号:US-4090025-A
优先权日:1976-04-26
标题 :Intermediates for synthesis of tetramisole, levamisole and their derivatives
发明人：RAGHU SIVARAMAN; HOFFMANN ARTHUR KENTARO; SINGH BALWANT
权利人:AMERICAN CYANAMID CO
摘要:A process for the manufacture of 1-(2-alkoxyethyl)-4-phenyl-4-imidazolin-2-ones, 1-(2-alkoxyethyl)-4-phenyl-2-imidazolidones, 1-(2-alkoxyethyl)-4-phenyl-imidazolidine-2-thiones, certain of the corresponding 1-(2-hydroxyethyl) derivatives and their 3-acylated derivatives, and certain related compounds which are all useful as intermediates in a new process for the manufacture of tetramisole, dl-2,3,5,6-tetrahydro-6-phenylimidazo-[2,1-b]thiazole, and its derivatives. The compound tetramisole is useful as an anthelmintic.