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4-Methylcinnamic Acid置于palladium On Activated Charcoal 氢气体系中,用 乙酸乙酯 用作溶剂,以92%的收率获得3-(4-甲苯)丙酸
参考文献:原位生成的二恶英酮对苯酚和茴香的区域选择性分子内氧化
标题:原位生成的二恶英酮对苯酚和茴香的区域选择性分子内氧化
摘要:已经开发了一种用于酚和茴香的区域选择性氧化的新方法,其中由酮和oxone原位生成的二恶英类化合物以分子内方式氧化酚衍生物.一系列具有吸电子基团的酮,例如cf(3),Coome和ch(2)cl,通过c(2)或c(3)亚甲基连接基连接到苯酚,茴香醚或芳基环上.在ch(3)cn和h(2)o的均相溶剂系统中,苯酚衍生物1-10的氧化反应以2-55%的收率获得螺2-羟基二烯酮,而与其他取代基的存在无关(邻位me,间位me或br)和芳基环的长度.提供了实验证据来支持涉及芳基环的区域选择性pi键环氧化,然后环氧化物重排和半缩酮形成的机制.
Doi:10.1021/jo000458J

专利信息

专利号:US-4544450-A
优先权日:1980-07-15
标 题 :Electrochemical process for the synthesis of organic compounds
发明人：OBERRAUCH ERMANNO; EBERSON LENNARD
权利人:ANIC SPA
摘要:An electrochemical process is disclosed for the synthesis of organic compounds, said process having the unique characteristic that the element evolved at the anode is exploited by having it reacting with the product of electrolysis obtained at the cathode by the presence of an appropriate catalyst. The catalyst may be associated in the most convenient manner to the anode, or it can be the anode itself. The process opens the way to a number of synthesis reaction which may be carried out electrolytically instead of the conventional ways.

专利号:US-5329022-A
优先权日:1991-01-16
标 题:Process for the synthesis of citraconimides
发明人：TALMA AUKE G; HOOFT HENDRIKA P M; VAN DE BOVENKAMP-BOUWMAN ANNA
权利人:AKZO AMERICA INC
摘要:The present invention relates to an improved synthesis method for the making of citraconimides wherein a citraconic anhydride is reacted with 0.5 to 2.0 equivalents of at least one amine salt. This process may be carried out in a solvent and generally leads to excellent yields of the citraconimides with high selectivity and easy purification. The present inventional so relates to a process for the production of citraconic anhydride from itaconic anhydride with an amine or phosphine catalyst and in a cosolvent.

专利号:US-9802952-B2
优先权日:2013-07-15
标 题:Method and apparatus for the synthesis of dihydroartemisinin and artemisinin derivatives
发明人：KOPETZKI DANIEL; MCQUADE DAVID TYLER; SEEBERGER PETER H; GILMORE KERRY
权利人:MAX-PLANCK-GESELLSCHAFT ZUR FÖRDERUNG DER WSS E V; MAX-PLANK-GESELLSCHAFT ZUR FÖRDERUNG DER WSS E V
摘要:The present invention is directed to a method for continuous production of dihydroartemisinin and also artemisinin derivatives derived from dihydroartemisinin by using artemisinin or dihydroartemisinic acid (DHAA) as starting material as well as to a continuous flow reactor for producing dihydroartemisinin as well as the artemisinin derivatives. It was found that the reduction of artemisinin to dihydroartemisinin in a continuous process requires a special kind of reactor and a special combination of reagents comprising a hydride reducing agent, at least one activator such as an inorganic activator, at least one solid base, at least one aprotic solvent and at least one C 1 -C 5 alcohol.

专利号:US-2004110228-A1
优先权日:2002-04-01
标 题:Combinatorial organic synthesis of unique biologically active compounds
发明人：MCALPINE SHELLI R; TAYLOR RACHEL E; BOLLA MEGAN L; SEGALL ANCA M
摘要:The invention provides a method for making a combinatorial library of cyclic compounds, such as Holliday junction-trapping compounds, comprising the steps of (a) obtaining a plurality of trimers according to the generic structure X 1- X 2- X 3 , wherein X 1 , X 2 and X 3 can be independently any naturally or nonnaturally occurring amino acids or peptidomimetics thereof; (b) optionally coupling a spacer S to the trimer at either end; (c) cyclizing two trimers or trimer-spacer conjugates in a head-to-tail orientation; thereby obtaining a combinatorial library of compounds, wherein the library does not include an unmodifed or naturally occurring Holliday Junction-trapping compounds. The invention additionally provides methods macrocyclic compounds that are synergimycin derivatives.

专利号:US-6531470-B1
优先权日:1998-01-23
标题:Oxazolidinone combinatorial libraries, compositions and methods of preparation
发明人：GORDEEV MIKHAIL F; LUEHR GARY W; PATEL DINESH V; NI ZHI-JIE; GORDON ERIC
权利人:UPJOHN CO
摘要:Oxazolidinones and methods for their synthesis are provided. Also provided are combinatorial libraries comprising oxazolidinones, and methods to prepare the libraries. Further provided are methods of making biologically active oxazolidinones as well as pharmaceutically acceptable compositions comprising the oxazolidinones. The methods of library preparation include the attachment of oxazolidinones to a solid support. The methods of compound preparation in one embodiment involve the reaction of an iminophosphorane with a carbonyl containing polymeric support.

专利号:EP-3515880-B1
优先权日:2017-03-17
标题:Methods and compositions for synthesis of encoded libraries
发明人：LI JIN; MORGAN BARRY A; Wan jinqiao; DOU DENGFENG; LIU GUANSAI; CHANG YONG; CHEN QIUXIA; WANG XING; XU YANSHAN; HU DONGYAN; LIU JIAN; CHENG XUEMIN
权利人:HITGEN INC