CAS: 13319-71-6; 2-Bromo-6-Methylphenol

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📜邻甲酚置于n-溴代丁二酰亚胺(Nbs),二异丙胺体系中,化学反应生成6-溴-2-甲基苯酚
参考文献:使用基于taddol的手性膦-亚磷酸酯配体的不对称加氢甲酰化
标题:使用基于taddol的手性膦-亚磷酸酯配体的不对称加氢甲酰化
摘要:在苯乙烯的不对称rh催化加氢甲酰化反应中,评估了一个由17个模块化且容易获得的酚衍生的手性膦-亚磷酸酯配体的小型文库.发现该反应的立体化学结果高度依赖于手性亚磷酸酯部分和酚骨架上的取代基.在所研究的配体中,在亚磷酸酯邻位带有大取代基的10型基于taddol的配体表现最佳,对映选择性高达85%ee,区域选择性>=98:2.活性催化剂的高压NMR [hrh(p-P)(co)2 ](pp = 10H)揭示了在铑处配体的赤道-顶峰配位.在实验过程中观测到的耦合常数的温度依赖性表明两种赤道-顶峰异构体之间处于平衡状态,其中亚磷酸酯占据赤道位置的异构体占主导地位.
Doi:10.1021/om9009735

专利信息

专利号:US-8101747-B2
优先权日:2009-03-31
标 题:Process for the synthesis of ivabradine and addition salts thereof with a pharmaceutically acceptable acid
发明人：PEGLION JEAN-LOUIS; DESSINGES AIMEE; SERKIZ BERNARD
权利人:PEGLION JEAN-LOUIS; DESSINGES AIMEE; SERKIZ BERNARD; SERVIER LAB
摘要:Process for the synthesis of ivabradine of formula (I): n nand addition salts thereof with a pharmaceutically acceptable acid.

专利号:US-4348370-A
优先权日:1980-01-08
标题:Ammonia synthesis with catalyst derived by heating on a support a salt selected from alkali metal, alkaline earth metal, iron and cobalt hexacyanocobaltates and hexacyanoruthenates
发明人：JOHNSON MARVIN M; TABLER DONALD C; NOWACK GERHARD P
权利人:PHILLIPS PETROLEUM CO
摘要:Synthesis of ammonia employing at least one salt selected from alkali metal-, an alkaline earth metal-, iron- and cobalt hexacyanocobaltate and hexacyanoruthenate on a suitable support and then heating the composition to provide it with suitable activity.

专利号:US-4309311-A
优先权日:1980-01-08
标 题 :Ammonia synthesis with catalyst derived by heating on a support a salt selected from alkali metal, alkaline earth metal, iron and cobalt hexacyanocobaltates and hexacyanoruthenates
发明人：JOHNSON MARVIN M; TABLER DONALD C; NOWACK GERHARD P
权利人:PHILLIPS PETROLEUM CO
摘要:Synthesis of ammonia employing at least one salt selected from alkali metal-, an alkaline earth metal-, iron- and cobalt hexacyanocobaltate and hexacyanoruthenate on a suitable support and then heating the composition to provide it with suitable activity.

专利号:US-5321143-A
优先权日:1988-05-26
标题 :Ruthenium-catalyzed production of cyclic sulfates
发明人：SHARPLESS K BARRY; GAO YUN
权利人:MASSACHUSETTS INST TECHNOLOGY
摘要:A ruthenium catalyzed method to synthesize cyclic sulfate compounds from the corresponding cyclic sulfites, and the cyclic sulfate reaction products obtained by this method. These cyclic sulfates further react with selected nucleophiles to give various substituted products. The method is an efficient means for the synthesis of chiral building blocks from tartaric acid enantiomers in high yields using an overall two-stage, one-pot reaction procedure. The chiral compounds can be transformed by nucleophilic reactions into chiral building blocks useful for the synthesis of natural biologically active products, such as antibiotics and pheromones.

专利号:EP-0468457-B1
优先权日:1990-07-24
标题 :Novel substituted piperidines and their use as inhibitors of cholesterol synthesis
发明人：MCCARTHY JAMES R; BARNEY CHARLOTTE L; WANNAMAKER MARION W
权利人:MERRELL DOW PHARMA
摘要:The present invention relates to a group of compounds which are novel substituted piperidines and which act to inhibit the synthesis of cholesterol in mammals and in fungi.

专利号:US-5112990-A
优先权日:1988-05-26
标 题 :Ruthenium-catalyzed production of cyclic sulfates
发明人：SHARPLESS K BARRY; GAO YUN
权利人:MASSACHUSETTS INST TECHNOLOGY
摘要:A ruthenium catalyzed method to synthesize cyclic sulfate compounds from the corresponding cyclic sulfites, and the cyclic sulfate reaction products obtained by this method. These cyclic sulfates further react with selected nucleophiles to give various substituted products. The method is an efficient means for the synthesis of chiral building blocks from tartaric acid enantiomers in high yields using an overall two-stage, one-pot reaction procedure. The chiral compounds can be transformed by nucleophilic reactions into chiral building blocks useful for the synthesis of natural biologically active products, such as antibiotics and pheromones.