CAS: 111-66-0; Oct-1-Ene

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CAS号54509-73-8 ethene | CAS号111-65-9 正辛烷 | CAS号3710-30-3 1,7-辛二烯 | CAS号629-27-6 1-碘辛烷 | CAS号1117-86-8 1,2-辛二醇 | CAS号112-05-0 正壬酸 | CAS号111-83-1 1-溴代正辛烷 | CAS号38841-98-4 辛基氯化镁 | CAS号28540-81-0 trans-1-chloro-... | CAS号629-05-0 1-辛炔 | CAS号1070-26-4 3-bromo-1,1,1-t... | CAS号111-65-9 正辛烷 | CAS号13389-42-9 反-2-辛烯 | CAS号2801-86-7 7,8-dimethyltet... | CAS号5685-42-7 1-(2,2-Dichloro... | CAS号557-35-7 2-溴辛烷 | CAS号152212-49-2 (+/-)-1,2-dibro... | CAS号67-72-1 六氯乙烷 | CAS号101823-24-9 1,1,2-trifluoro... | CAS号1070-25-3 1,1,1,3-tetrabr...

1,2-辛二醇置于,三苯基膦体系中,用 甲苯 用作溶剂,以17%的收率获得辛烯
参考文献:用于脱氧脱水反应的基于萨兰配体的钼催化剂
标题:用于脱氧脱水反应的基于萨兰配体的钼催化剂
摘要:基于萨兰配体的二氧钼配合物在催化脱氧脱水(dodh)反应中的潜力已被评估. Dodh 反应是一种形式还原反应,使用含氧金属催化剂和牺牲还原剂将邻位二醇转化为烯烃.该反应在将生物质衍生的分子转化为平台化学品方面具有巨大的潜力.本研究评估了 Dodh 反应中由萨兰配体支持的二十 (20) 个钼配合物,目的是建立结构-活性关系.使用苯乙烯乙二醇作为模型底物和 1-10 Mol% 的钼络合物负载量,在 170 oc 下进行催化剂筛选,产生苯乙烯,产率高达 54%.脂肪族二醇和内消旋/r,R-氢化苯偶姻也以中等至非常好的收率(60-71%)转化为相应的烯烃,与之前报道的钼催化剂相当.使用 10 Mol% 催化剂,生物来源的二醇(+)-酒石酸二乙酯可以转化为烯烃产品(富马酸二乙酯),产率 >98%.使用na 2 So 3 (廉价,易得且良性)作为还原剂也获得了高产率的富马酸二乙酯(78%).非常重要的是,在
Doi:10.1039/d4Cy00441H

专利信息

专利号:US-11866398-B2
优先权日:2018-05-15
标 题:Total synthesis of prostaglandin J natural products by stereoretentive metathesis
发明人：LI JIAMING; CHEN XU; AHMED TONIA S; STOLTZ BRIAN M; GRUBBS ROBERT H
权利人:CALIFORNIA INST OF TECHN
摘要:This invention relates generally to the synthesis of Δ12-Prostaglandin J product using stereoretentive ruthenium olefin metathesis catalysts supported by dithiolate ligands. Δ12-Prostaglandin J products were generated with excellent selectivity (>99% Z) and in moderate to high/good yields (47% to 80% yield; 58% to 80% yield).

专利号:US-8314015-B2
优先权日:2010-07-14
标题 :Silicon surface modification for the electrochemical synthesis of silicon particles in suspension
发明人：TU CHANG-CHING; TANG LIANG; VOUTSAS APOSTOLOS T
权利人:TU CHANG-CHING; TANG LIANG; VOUTSAS APOSTOLOS T; SHARP LAB OF AMERICA INC
摘要:A process of silicon (Si) surface modification is provided for the electrochemical synthesis of Si particles in suspension. The process begins with a Si first substrate with a surface, and forms Si particles attached to the surface. Hydrogen-terminated Si particles are created and the first substrate is immersed in a hexane/1-octene (1/1 volume ratio) solution with a catalytic amount of chloroplatinic acid (H 2 PtCl 6 ). 1-octene is bonded with the hydrogen-terminated Si particles, creating modified Si particles, with octane capping ligands, attached to the substrate surface. The first substrate is then exposed to ultrasonication, separating the modified Si particles from the first substrate. After removing the first substrate, a suspension is created of modified Si particles suspended in excess hexane/1-octene.

专利号:US-11548898-B2
优先权日:2017-07-06
标题 :Synthesis of halichondrins
发明人：KISHI YOSHITO; AI YANRAN; YE NING; WANG QIAOYI; YAHATA KENZO; ISO Kentaro; NAINI SANTHOSH REDDY; YAMASHITA SHUJI; LEE JIHOON; OHASHI ISAO; FUKUYAMA TAKASHI
权利人:HARVARD COLLEGE; EISAI R&D MAN CO LTD
摘要:The present invention provides methods for the synthesis of ketones involving a Ni/Zr-mediated coupling reaction. The Ni/Zr-mediated ketolization reactions can be used in the synthesis of halichondrins (e.g., halichondrin A, B, C; homohalichondrin A, B, C; norhalichondrin A, B, C), and analogs thereof. Therefore, the present invention also provides synthetic methods useful for the synthesis of halichondrins, and analogs thereof. Also provided herein are compounds (i.e., intermediates) useful in the synthesis of halichondrins, and analogs thereof. In particular, the present invention provides methods and compounds useful in the synthesis of compound of Formula (H3-A).

专利号:US-2008032964-A1
优先权日:2006-04-10
标题:Process for the synthesis of azetidinone
发明人：KANSAL VINOD K; AHMAD SUHAIL; MARIAPPAN SHANMUGAVEL; TYAGI BHUPENDRA; PERLMAN NURIT; LE PAIH JACQUES; ZANOTTI-GEROSA ANTONIO
权利人:KANSAL VINOD K; AHMAD SUHAIL; MARIAPPAN SHANMUGAVEL; TYAGI BHUPENDRA; PERLMAN NURIT; LE PAIH JACQUES; ZANOTTI-GEROSA ANTONIO
摘要:Provided are intermediates useful for the synthesis of hydroxyl-alkyl substituted azetidinones, processes of their preparation, and processes for the synthesis of certain hydroxyl-alkyl substituted azetidinones. Also provided are processes for the synthesis of 1-(4-fluorophenyl)-3(R)-[3-(4-fluorophenyl)-3(S)-hydroxypropyl]-4(S)-(4-hydroxyphenyl)-2-azetidinone, or ezetimibe.

专利号:US-7230101-B1
优先权日:2002-08-28
标 题:Synthesis of methotrexate-containing heterodimeric molecules
发明人：MURTHI KRISHNA K; SMITH CHASE C
权利人:GPC BIOTECH INC
摘要:The present invention relates to novel compositions of methotrexate-containing heterodimeric probe molecules, also known as chemical inducers of dimerization (CID), useful in three-hybrid assays. The invention further relates to synthesis of said compositions and their intermediates. Another aspect of the invention is a method for using the heterodimeric probe molecules described herein in drug screens to identify potential protein targets to a given ligand, optimize protein-ligand interactions, or identify potential ligands for a given protein target. In certain embodiments, the invention contemplates the synthesis of the following methotrexate-containing heterodimeric probe:

专利号:US-7344863-B2
优先权日:1998-03-13
标题:Methods for producing polypeptides through enhanced synthesis of encoding nucleic acid molecules
发明人：LI WU-BO; JESSEE JOEL A; SCHUSTER DAVID; XIA JIULIN; GEBEYEHU GULILAT
权利人:INVITROGEN CORP
摘要:The present invention is directed to compositions and methods for enhancing synthesis of nucleic acid molecules, particularly GC-rich nucleic acid molecules. Specifically, the invention provides compositions comprising one or more nitrogen-containing organic compounds having a formula selected from the group consisting of formula I and formula II (or salts or derivatives thereof), preferably 4-methylmorpholine N-oxide or betaine (carboxymethyltrimethylammonium), and further comprising one or more compounds selected from the group consisting of proline and an N-alkylimidazole compound, and more preferably proline, 1-methylimidazole or 4-methylimidazole. The invention further relates to methods for enhanced, high-fidelity synthesis of nucleic acid molecules, including via amplification (particularly PCR), reverse transcription, and sequencing methods. The invention also relates to nucleic acid molecules synthesized by these methods, to fragments or derivatives thereof, and to vectors and host cells comprising such nucleic acid molecules, fragments, or derivatives. The invention also relates to kits for synthesizing, amplifying, reverse transcribing or sequencing nucleic acid molecules comprising one or more of the compositions of the invention.