CAS: 98224-03-4; 1-(2,3-Dihydrobenzo[b][1,4]Dioxin-5-yl)Piperazine Hydrochloride

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CAS号821-48-7 二(2-氯乙基)胺盐酸盐 | CAS号16081-45-1 5-氨基-1,4-苯并二恶烷 | CAS号58328-39-5 5-溴-2,3-二氢-1,4-苯并二氧烷 | CAS号4442-53-9 2,3-二氢-1,4-苯并二烷-5-羧酸

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    📜2,3-二氢-1,4-苯并二烷-5-羧酸置于盐酸,Sodium Azide,三乙胺体系中,用 水,氯苯,丙酮 作为反应溶剂,化学反应生成 1-(2,3-二氢-1,4-苯并二烷-5-基)哌嗪盐酸盐
    参考文献: Functionally Selective Ligands Of Dopamine D2 Receptors[fr] Ligands Fonctionnellement Sélectifs Des Récepteurs D2 De Dopamine
    标题: Functionally Selective Ligands Of Dopamine D2 Receptors[fr] Ligands Fonctionnellement Sélectifs Des Récepteurs D2 De Dopamine

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    专利信息


    专利号:US-2006194971-A1
    优先权日:2005-02-24
    标 题 :Anethole dithiolethione and other dithiolethiones for the treatment of conditions associated with dysfunction of monoamine neruotransmission
    发明人：DRUKARCH BENJAMIN; SCHOFFELMEER ANTON N; FEENSTRA ROELOF W; CHRISTEN MARIE-ODILE; BURGOT JEAN-LOUIS; CHOLLET MARYLENE; IWEMA BAKKER WOUTER I; VAN VLIET BERNARD J; TULP MARTINUS T
    权利人:DRUKARCH BENJAMIN; SCHOFFELMEER ANTON N; FEENSTRA ROELOF W; CHRISTEN MARIE-ODILE; BURGOT JEAN-LOUIS; CHOLLET MARYLENE; IWEMA BAKKER WOUTER I; VAN VLIET BERNARD J; TULP MARTINUS T
    摘要:The present disclosure relates to dithiolethione derivatives as monoamino oxidase inhibitors, in particular MAO-B inhibitors, to methods for the preparation of these compounds and to novel intermediates useful for the synthesis of said dithiolethiones derivatives. The present disclosure also relates to the use of a compound disclosed herein for the manufacture of a medicament giving a beneficial effect. In embodiments of the present disclosure specific compounds disclosed herein are used for the manufacture of a medicament useful in the treatment, amelioration or prevention of conditions associated with dysfunction of monoamine neurotransmission. The compounds have the general formula (1) n nwherein the symbols have the meanings given in the specification.

    专利号:RU-2726764-C1
    优先权日:2019-12-18
    标 题:Recombinant plasmid dna aav synh1-2_shrna freud-1, providing synthesis of shphk, suppressing expression of gene coding selective silenser 5-ht1a of receptor freud-1, in brains of mammals

    专利号:US-2023271983-A1
    优先权日:2020-07-29
    标题 :Functionalized isonitriles and products, preparation and uses thereof
    发明人：SOTELO PÉREZ EDDY; AZUAJE GUERRERO JHONNY ALBERTO; MAJELLARO MARIA
    权利人:UNIV SANTIAGO COMPOSTELA
    摘要:The present invention relates to functionalized isonitrile compounds, formed by means of multicomponent environmentally friendly reactions, suitable for coupling to functional molecules such as biomolecules, APIs, chromophore and fluorophore molecules. The invention also relates to conjugates between said isonitrile compounds and functional molecules, which are useful in the synthesis of pharmaceutic drugs or tools, fluorescent molecules and labels, polymeric smart materials. The invention furthermore provides a kit for the in-vitro preparation of the functionalized isontrile compounds and conjugates. The invention also contemplates the medical use of said compounds and conjugates.

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    合成参考文献


    参考文献:10.1016/0924-977x(95)00051-p
    摘要:Mos J, van Aken HH, van Oorschot R, Olivier B. Chronic treatment with eltoprazine does not lead to tolerance in its anti-aggressive action, in contrast to haloperidol. Eur Neuropsychopharmacol. 1996 Mar;6(1):1–7. doi: 10.1016/0924-977x(95)00051-p.
    参考文献:10.1007/bf02246645
    摘要:Fone KC, Shalders K, Fox ZD, Arthur R, Marsden CA. Increased 5-HT2C receptor responsiveness occurs on rearing rats in social isolation. Psychopharmacology (Berl). 1996 Feb;123(4):346–52. doi: 10.1007/bf02246645.
    参考文献:10.1007/s40263-020-00754-0
    摘要:Gonzalez-Latapi P, Bhowmick SS, Saranza G, Fox SH. Non-Dopaminergic Treatments for Motor Control in Parkinson's Disease: An Update. CNS Drugs. 2020 Oct;34(10):1025–44. doi: 10.1007/s40263-020-00754-0.
    参考文献:10.1007/bf01839187
    摘要:Kaya F, van Duin CTM, Veenendaal GH, van Miert ASJPAM. Food intake and rumen motility in dwarf goats. Effects of some serotonin receptor agonists and antagonists. Veterinary Research Communications. 1992 Sep;16(5):379–90. doi: 10.1007/bf01839187.
    参考文献:10.1021/jm960496o
    摘要:Kuipers W, Kruse CG, van Wijngaarden I, Standaar PJ, Tulp MTM, Veldman N, Spek AL, IJzerman AP. 5-HT1A- versus D2-Receptor Selectivity of Flesinoxan and AnalogousN 4-SubstitutedN 1-Arylpiperazines. J. Med. Chem. 1997 Jan 01;40(3):300–12. doi: 10.1021/jm960496o.
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