CAS: 97825-25-7; 4-[3-[[2-Hydroxy-2-(4-Hydroxyphenyl)Ethyl]Amino]Butyl]Phenol

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CAS号90274-24-1 盐酸莱克多巴胺 | CAS号90274-24-1 盐酸莱克多巴胺

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  • 52446-58-9 = 97825-25-7
    反应条件:1.1 Reagents: Sodium Hydroxide,Sodium Borohydride Solvents: Methanol; Cooled; 6 H,Rt1.2 Reagents: Sodium Borohydride
    标题:Process For Preparation Of Ractopamine
    参考文献:China]

    887914-30-9 + 2491-38-5 = 97825-25-7
    反应条件:1.1 Reagents: Sodium Carbonate Solvents: Ethyl Acetate,Water; 20 Min,Rt; 2.5 H,Rt1.2 Solvents: Ethyl Acetate; 2 H,Rt1.3 Reagents: Hydrochloric Acid Solvents: Water; 30 Min,Ph 5,140 °C; Cooled2.1 Reagents: Sodium Hydroxide,Sodium Borohydride Solvents: Methanol; Cooled; 6 H,Rt2.2 Reagents: Sodium Borohydride
    标题:Process For Preparation Of Ractopamine
    参考文献:China]

    71707-27-2 + 93822-20-9 = 97825-25-7 [标题:Reaction Conditions
    标题:Animal Feed Compositions Containing Phenethanolamines
    参考文献:United Kingdom]

    = 97825-25-7 [标题:Reaction Conditions
    标题:Improved Process For The Preparation Of Ractopamine Hydrochloridea Process For The Preparation Of Ractopamine
    参考文献:India]

    74432-58-9 = 97825-25-7 [标题:Reaction Conditions
    标题:Animal Feed Compositions Containing Phenethanolamines
    参考文献:United Kingdom]

    5471-51-2 = 97825-25-7
    反应条件:1.1 Reagents: Acetic Acid,Hydroxyamine Hydrochloride Solvents: Water; 2 H,130 °C; 2 H,150 °C; Cooled1.2 Reagents: Hydrochloric Acid Solvents: Water; 25 Min,Reflux; Cooled2.1 Reagents: Sodium Carbonate Solvents: Ethyl Acetate,Water; 20 Min,Rt; 2.5 H,Rt2.2 Solvents: Ethyl Acetate; 2 H,Rt2.3 Reagents: Hydrochloric Acid Solvents: Water; 30 Min,Ph 5,140 °C; Cooled3.1 Reagents: Sodium Hydroxide,Sodium Borohydride Solvents: Methanol; Cooled; 6 H,Rt3.2 Reagents: Sodium Borohydride
    标题:Process For Preparation Of Ractopamine
    参考文献:China
📜盐酸莱克多巴胺置于sodium Hydroxide体系中,用 水 作为反应溶剂,化学反应 0.5H,反应生成 莱克多巴胺
参考文献:Use Of Rr/sr-Ractopamine
标题:Use Of Rr/sr-Ractopamine
摘要:本发明公开了一种通过向动物投与rr-拉托巴胺和sr-拉托巴胺混合物的治疗有效量来促进或改善动物的饲料效率和肌肉脂肪比的方法.同时,还公开了制造rr/sr-拉托巴胺的方法.

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专利信息


专利号:US-9353057-B2
优先权日:2003-12-30
标 题:Synthesis of acyloxyalkyl carbamate prodrugs and intermediates thereof
发明人：GALLOP MARK A; DAI XUEDONG; SCHEUERMAN RANDALL A; RAILLARD STEPHEN P; MANTHATI SURESH K; YAO FENMEI; PHAN THU; LUDWIKOW MARIA; PENG GE; BHAT SEEMA
权利人:XENOPORT INC
摘要:Methods for synthesis of 1-(acyloxy)-alkyl carbamates, particularly, the synthesis of 1-(acyloxy)-alkyl carbamate prodrugs of primary or secondary amine-containing drugs are described. Also described are methods for synthesis of 1-(acyloxy)-alkyl N-hydroxysuccinimidyl carbonates which are useful intermediates in the synthesis of 1-(acyloxy)-alkyl carbamates are also described.

专利号:US-8017776-B2
优先权日:2003-07-15
标题 :Methods for synthesis of acyloxyalkyl compounds
发明人：BHAT LAXMINARAYAN; GALLOP MARK A
权利人:XENOPORT INC
摘要:Disclosed herein are methods for synthesizing 1-(acyloxy)-alkyl prodrug derivatives of drugs through oxidation of 1-acyl-alkyl derivatives of drugs under anhydrous reaction conditions. The methods typically proceed stereospecifically, in high yield, do not require the use of activated intermediates and/or toxic compounds and are readily amenable to scale-up.

专利号:US-2015158809-A9
优先权日:2013-02-26
标 题 :Method of making 1-(acyloxy)-alkyl carbamate compounds
发明人：WANG HUAN; LIU PENG; DAI QUNYING; YIN HAO; RAILLARD STEPHEN P
权利人:XENOPORT INC
摘要:Methods of preparing carbamate prodrugs of amine-containing drugs are provided. Carbonates useful in the synthesis of the carbamate prodrugs are also provided.

专利号:US-8143437-B2
优先权日:2002-02-19
标题:Methods for synthesis of prodrugs from 1-acyl-alkyl derivatives and compositions thereof
发明人：GALLOP MARK A; XIANG JIA-NING; YAO FENMEI; BHAT LAXMINARAYAN; ZHOU CINDY X
权利人:GALLOP MARK A; XIANG JIA-NING; YAO FENMEI; BHAT LAXMINARAYAN; ZHOU CINDY X; XENOPORT INC
摘要:The present invention provides a method for synthesizing 1-(acyloxy)-alkyl derivatives from 1-acyl-alkyl derivatives, which typically proceeds stereospecifically, in high yield, does not require the use of activated intermediates and/or toxic compounds and is readily amendable to scale-up. The current invention also provides 1-acyl-alkyl derivatives of known drug components and methods for synthesizing these 1-acyl-alkyl derivatives.

专利号:CA-2551859-C
优先权日:2003-12-30
标题 :Synthesis of acyloxyalkyl carbamate prodrugs and intermediates thereof

专利号:EP-2250143-A2
优先权日:2008-01-25
标题 :Method for the enzymatic kinetic resolution of acyloxyalkyl thiocarbonates used for the synthesis of acyloxyalkyl carbamates

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合成参考文献


参考文献:10.1007/s00216-010-3484-3
摘要:Peters RJB, Oosterink JE, Stolker AAM, Georgakopoulos C, Nielen MWF. Generic sample preparation combined with high-resolution liquid chromatography–time-of-flight mass spectrometry for unification of urine screening in doping-control laboratories. Analytical and Bioanalytical Chemistry. 2010 Feb 16;396(7):2583–98. doi: 10.1007/s00216-010-3484-3.
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