CAS: 93634-87-8; Tert-Butyl(Dicyclohexyl)Phosphane

上下游产品

tert.-butyl lithium chlorodicyclohexylphosphane dicyclohexyl(1,1-dimethylethyl)phosphine-trihydridoboronDicyclohexyl-(3-phenylpropyl)phosphine dicyclohexyl(2-(4-phenyl)butyl)phosphine dicyclohexyl(3-(3,5-dimethyl)phenylpropyl)-phosphine

T-Bucy2Ph(+)Bf4(-)置于奎宁环体系中,用 甲苯 作为反应溶剂,化学反应生成 叔丁基二环己基膦
参考文献:路易斯碱离核参数 Nfb 及其在 Mida-硼酸盐水解动力学分析中的应用
标题:路易斯碱离核参数 Nfb 及其在 Mida-硼酸盐水解动力学分析中的应用
摘要:已经测量了从广泛的路易斯碱硼烷加合物中置换 Bh 3的奎宁环动力学.这些速率的参数化使得能够开发出离核量表 (Nf B),以量化和预测一系列其他路易斯碱基的离去基团能力.在多个系列 R' 3-N R N X (X = P,N; R' = 芳基,烷基) 中观测到的可加性允许制定相关的取代基参数 (N F Pb,N F Ab),提供了一种方法计算n F B一系列路易斯碱基的值远远超出了实验得出的值.通过取代基参数n F Pb与一系列烷基和芳基 Mida 硼酸盐在中性条件下的水解速率的相关性,探索了核离性参数的效用.这允许鉴定具有接近反应中心的杂原子的 Mida 硼酸盐,显示出不寻常的动力学不稳定性或水解稳定性.
DOI:10.1021/acs.Joc.1C02729

专利信息

专利号:US-8114993-B2
优先权日:2007-02-06
标题:Use of aryl chlorides in palladium-catalyzed C-H bond functionalization
发明人：DAUGULIS OLAFS; CHIONG HENDRICH
权利人:DAUGULIS OLAFS; CHIONG HENDRICH; UNIV HOUSTON SYSTEM
摘要:A one-step method for efficiently converting carbon-hydrogen bonds into carbon-carbon bonds using chloroarenes and palladium catalysts is disclosed. This method allows faster introduction of complex molecular entities, a process that would otherwise require many more steps. This invention is particularly relevant for the organic synthesis of complex molecules such as, but not limited to, pharmacophores.

专利号:US-2022056008-A1
优先权日:2018-12-21
标 题:Process and intermediates for the synthesis of voxelotor
发明人：FERREIRO GIL JUAN JOSÉ; IGLESIAS RETUERTO JESÚS MIGUEL; LORENTE BONDE-LARSEN ANTONIO
权利人:CRYSTAL PHARMA SAU
摘要:The invention relates to a process for the preparation of Voxelotor, or a salt or solvate thereof, according to the following scheme (Formula 1).

专利号:US-2016223559-A1
优先权日:2015-02-02
标题:Tetrazine-containing compounds and synthetic methods thereof
发明人：DEVARAJ NEAL K; WU HAOXING; YANG JUN
权利人:UNIV CALIFORNIA
摘要:Described herein are tetrazine derivatives and efficient synthetic methods of synthesis thereof using elimination-Heck cascade reaction. Provided herein is the synthesis of conjugated tetrazines from the tetrazine derivatives. Also provided herein are methods of use of the conjugated tetrazines as fluorogenic probes for live-cell imaging.