CAS: 883230-94-2; 5-Bromo-2-Pyrazol-1-Yl-Pyrimidine
该化合物是一种七相循环化合物,其5位置为火利米丁核心,以溴原子替代5位置,2位置为阳利焦耳.这种结构在合成应用中,特别是在制药和农用化学研究中,具有多功能性,是进一步实现功能化的关键中间环节.溴替代性能增强交叉反应的回动性,如铃木或布奇瓦尔德-哈特维格的交织,使多种丙烯或乙酰胺组得以引入.这种环有助于潜在的生物活动,使这种化合物在生物活性分子的开发中具有价值.在标准条件下,其定义明确的再活动性和稳定性促进了其在多步骤合成途径的使用.
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CAS号288-13-1 吡唑 | CAS号32779-36-5 5-溴-2-氯嘧啶合成工艺路线路线简述
- 288-13-1 + 883230-69-1 = 883230-94-2
反应条件:1.1 Reagents: Cesium Carbonate,Oxygen Catalysts: Cupric Nitrate Solvents: Dimethylformamide; 24 H,130 °C
标题:Copper-Catalyzed C-N Bond Exchange Of N-Heterocyclic Substituents Around Pyridine And Pyrimidine Cores
作者:Tao,Sheng; Et Al
参考文献:Synthesis 日期:2017 卷标:49(23) 页码:5120-5130]
288-13-1 + 883230-68-0 = 883230-94-2
反应条件:1.1 Reagents: Cesium Carbonate,Oxygen Catalysts: Cupric Nitrate Solvents: Dimethylformamide; 24 H,130 °C
标题:Copper-Catalyzed C-N Bond Exchange Of N-Heterocyclic Substituents Around Pyridine And Pyrimidine Cores
作者:Tao,Sheng; Et Al
参考文献:Synthesis 日期:2017 卷标:49(23) 页码:5120-5130]
288-32-4 = 883230-94-2
反应条件:1.1 Reagents: Potassium Carbonate,Oxygen Solvents: Dimethyl Sulfoxide; 24 H,Rt -> 70 °C2.1 Reagents: Cesium Carbonate,Oxygen Catalysts: Cupric Nitrate Solvents: Dimethylformamide; 24 H,130 °C
标题:Copper-Catalyzed C-N Bond Exchange Of N-Heterocyclic Substituents Around Pyridine And Pyrimidine Cores
作者:Tao,Sheng; Et Al
参考文献:Synthesis 日期:2017 卷标:49(23) 页码:5120-5130]
51-17-2 = 883230-94-2
反应条件:1.1 Reagents: Potassium Carbonate,Oxygen Solvents: Dimethyl Sulfoxide; 24 H,Rt -> 70 °C2.1 Reagents: Cesium Carbonate,Oxygen Catalysts: Cupric Nitrate Solvents: Dimethylformamide; 24 H,130 °C
标题:Copper-Catalyzed C-N Bond Exchange Of N-Heterocyclic Substituents Around Pyridine And Pyrimidine Cores
作者:Tao,Sheng; Et Al
参考文献:Synthesis 日期:2017 卷标:49(23) 页码:5120-5130]
288-13-1 + 32779-36-5 = 883230-94-2
反应条件:1.1 Reagents: Potassium Carbonate,Oxygen Solvents: Dimethyl Sulfoxide; 24 H,Rt -> 70 °C
标题:Metal-Free Site-Selective C-N Bond-Forming Reaction Of Polyhalogenated Pyridines And Pyrimidines
作者:Wang,Lei; Et Al
参考文献:Rsc Advances 日期:2015 卷标:5(100) 页码:82097-82111]
288-13-1 = 883230-94-2
反应条件:1.1 Reagents: Cesium Carbonate,Oxygen Catalysts: Cupric Nitrate Solvents: Dimethylformamide; 24 H,130 °C
标题:Copper-Catalyzed C-N Bond Exchange Of N-Heterocyclic Substituents Around Pyridine And Pyrimidine Cores
作者:Tao,Sheng; Et Al
参考文献:Synthesis 日期:2017 卷标:49(23) 页码:5120-5130]
288-13-1 + 478258-70-7 = 883230-94-2
反应条件:1.1 Reagents: Cesium Carbonate,Oxygen Catalysts: Cupric Nitrate Solvents: Dimethylformamide; 24 H,130 °C
标题:Copper-Catalyzed C-N Bond Exchange Of N-Heterocyclic Substituents Around Pyridine And Pyrimidine Cores
作者:Tao,Sheng; Et Al
参考文献:Synthesis 日期:2017 卷标:49(23) 页码:5120-5130]
= 883230-94-2
反应条件:1.1 Reagents: Potassium Carbonate,Oxygen Solvents: Dimethyl Sulfoxide; 24 H,Rt -> 70 °C2.1 Reagents: Cesium Carbonate,Oxygen Catalysts: Cupric Nitrate Solvents: Dimethylformamide; 24 H,130 °C
标题:Copper-Catalyzed C-N Bond Exchange Of N-Heterocyclic Substituents Around Pyridine And Pyrimidine Cores
作者:Tao,Sheng; Et Al
参考文献:Synthesis 日期:2017 卷标:49(23) 页码:5120-5130]
120-72-9 = 883230-94-2
反应条件:1.1 Reagents: Potassium Carbonate,Oxygen Solvents: Dimethyl Sulfoxide; 24 H,Rt -> 70 °C2.1 Reagents: Cesium Carbonate,Oxygen Catalysts: Cupric Nitrate Solvents: Dimethylformamide; 24 H,130 °C
标题:Copper-Catalyzed C-N Bond Exchange Of N-Heterocyclic Substituents Around Pyridine And Pyrimidine Cores
作者:Tao,Sheng; Et Al
参考文献:Synthesis 日期:2017 卷标:49(23) 页码:5120-5130
📜吡唑,1-(5-Bromopyrimidin-2-yl)-1H-Benzo[d]Imidazole置于caesium Carbonate,Copper(II) Nitrate体系中,用 N,N-二甲基甲酰胺 作为反应溶剂,化学反应 24.0H,以62%的收率获得产物5-溴-2-吡唑-1-基-嘧啶
参考文献:铜和嘧啶核周围的n-杂环取代基的铜催化c-n键交换
标题:铜和嘧啶核周围的n-杂环取代基的铜催化c-n键交换
摘要:S. Tao和e. Ji的贡献相等. 抽象的 描述了使用c-n键交换反应的铜催化转移n-杂芳基化策略.该反应可容纳范围广泛的带有卤素原子的吡啶和嘧啶环,它们对于随后的转化具有广泛的用途.该方法提供了直接且操作简单的方法,用于通过交换n杂环取代基来修饰复杂分子. 描述了使用c-n键交换反应的铜催化转移n-杂芳基化策略.该反应可容纳范围广泛的带有卤素原子的吡啶和嘧啶环,它们对于随后的转化具有广泛的用途.该方法提供了直接且操作简单的方法,用于通过交换n杂环取代基来修饰复杂分子.
DOI:10.1055/s-0036-1590893
专利信息
专利号:US-2010286211-A1
优先权日:2004-10-08
标题:Oxazolidinone derivatives as antimicrobials
发明人：DAS BISWAJIT; AHMED SHAHADAL; YADAV AJAY SINGH; GHOSH SOMA; GUJRATI ARTI; SHARMA PANKAJ; RATTAN ASHOK
权利人:DAS BISWAJIT; AHMED SHAHADAL; YADAV AJAY SINGH; GHOSH SOMA; GUJRATI ARTI; SHARMA PANKAJ; RATTAN ASHOK
摘要:The present invention relates to certain substituted phenyl oxazolidinones and to processes for the synthesis of the same. This invention also relates to pharmaceutical compositions containing the compounds of the present invention as antimicrobials. The compounds are useful antimicrobial agents, effective against a number of human and veterinary pathogens, including gram-positive aerobic bacteria, for example, multiple-resistant staphylococci, streptococci and enterococci as well as anaerobic organisms, for example, Bacterioides spp. and Clostridia spp. species, and acid fast organisms, for example, Mycobacterium tuberculosis, Mycobacterium avium and Mycobacterium spp.
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品牌试剂参考报价(招募中)
📌 第三方产品分析报告
主要参考文献
参考标题: Oxazolidinone Derivatives As Antimicrobials Derives D'Oxazolidinone Utilises Comme Agents Antimicrobiens摘要:The Present Invention Relates To Certain Substituted Phenyl Oxazolidinones And To Processes For The Synthesis Of The Same. This Invention Also Relates To Pharmaceutical Compositions Containing The Compounds Of The Present Invention As Antimicrobials. The Compounds Are Useful Antimicrobial Agents, Effective Against A Number Of Human And Veterinary Pathogens, Including Gram-Positive Aerobic Bacteria, For Example, Multiple-Resistant Staphylococci, Streptococci And Enterococci As Well As Anaerobic Organisms, For Example, Bacterioides Spp. And Clostridia Spp. Species, And Acid Fast Organisms, For Example, Mycobacterium Tuberculosis, Mycobacterium Avium And Mycobacterium Spp.
合成参考文献
参考文献:10.1055/s-0036-1590893
摘要:Tao S, Ji E, Shi L, Liu N, Xu L, Dai B. Copper-Catalyzed C–N Bond Exchange of N-Heterocyclic Substituents around Pyridine and Pyrimidine Cores. Synthesis. 2017 Aug 28;49(23):5120–30. doi: 10.1055/s-0036-1590893.
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