CAS: 79-55-0; 1,2,2,6,6-Pentamethylpiperidine

该化合物是一种循环有机化合物,其特点是其管状体结构,这是一个由六人组成的环,内含一个氮原子;该化合物的五组甲基附着于管状环,特别是1,2,6和6个位置,具有独特的特性;它没有色素,淡黄色液体有独特的气味,以其相对较低的挥发性而著称;多种甲基组的存在,增加了其股积,并能够影响其在各个溶剂中的再活性和溶性;1,2,6,6-Penta-metrophypridine,由于能够分离自由基质,经常被用作有机合成中的试剂,并作为聚合物化学中的稳定剂;重要的是,要谨慎地处理这一化合物,因为它可能对接触健康造成危害.

结构式图片

相似化合物

40327-96-6 25665-47-8 865074-84-6

物理性质

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欧盟法规

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上下游产品

CAS号771436-36-3 1,2,2,6,6-penta... | CAS号54262-97-4 2,2,6,6-tetrame... | CAS号768-66-1 2,2,6,6-四甲基哌啶 | CAS号50-00-0 甲醛 | CAS号74-88-4 碘甲烷 | CAS号80-48-8 对甲苯磺酸甲酯 | CAS号1193-82-4 苯亚砜甲酯 | CAS号617-94-7 2-苯基-2-丙醇 | CAS号220418-56-4 | CAS号768-66-1 2,2,6,6-四甲基哌啶 | CAS号5132-07-0 2,2,6,6-tetrame... | CAS号54262-97-4 2,2,6,6-tetrame... | CAS号13304-52-4 2-METHYL-3-PHEN... | CAS号77387-57-6 3,5-二叔丁基苄醇 | CAS号80220-93-5 butyl 3-phenylp... | CAS号100-51-6 苯甲醇

合成工艺路线路线简述

  • 768-66-1 = 79-55-0
    反应条件:1.1 Reagents: Phenylsilane Catalysts: 2278261-44-0 Solvents: Dimethylacetamide; 2 H,60 °C
    标题:Uio-Type Metal-Organic Frameworks With Nhc Or Metal-Nhc Functionalities For N-Methylation Using Co2 As The Carbon Source
    作者:Zhang,Xu; Jiang,Yilin; Fei,Honghan
    参考文献:Chemical Communications (Cambridge 日期:2019 卷标:55(79) 页码:11928-11931]

    768-66-1 = 79-55-0
    反应条件:1.1 Reagents: 9-Bbn Dimer Catalysts: 2,8,9-Trimethyl-2,5,8,9-Tetraaza-1-Phosphabicyclo[3.3.3]Undecane Solvents: Thf-D8; 1 H,1 Bar,90 °C
    标题:Carbon Dioxide Reduction To Methylamines Under Metal-Free Conditions
    作者:Blondiaux,Enguerrand; Pouessel,Jacky; Cantat,Thibault
    参考文献:Angewandte Chemie 日期:2014 卷标:53(45) 页码:12186-12190]

    768-66-1 = 79-55-0
    反应条件:1.1 Reagents: Poly(Methylhydrosiloxane) Catalysts: Phosphonium,Methyltriphenyl-,Methyl Carbonate (1:1) Solvents: Tetrahydrofuran; 16 H,1 Bar,70 °C
    标题:Tuneable Reduction Of Co2 - Organocatalyzed Selective Formylation And Methylation Of Amines
    作者:Ren,Changyue; Terazzi,Constanza; Werner,Thomas
    参考文献:Green Chemistry 日期:2024 卷标:26(1) 页码:439-447]

    768-66-1 = 79-55-0
    反应条件:1.1 Reagents: Phenylsilane Solvents: Dimethylformamide; 24 H,1 Atm,90 °C; 90 °C -> Rt1.2 Reagents: Water; Rt
    标题:Catalyst-Free N-Methylation Of Amines Using Co2
    作者:Niu,Huiying; Lu,Lijun; Shi,Renyi; Chiang,Chien-Wei; Lei,Aiwen
    参考文献:Chemical Communications (Cambridge 日期:2017 卷标:53(6) 页码:1148-1151]

    768-66-1 = 79-55-0
    反应条件:1.1 Reagents: Triethylamine Solvents: Toluene; 16 H,130 °C
    标题:Transition Metal-Free Methylation Of Amines With Formaldehyde As The Reductant And Methyl Source
    作者:Man,Nikki Y. T.; Li,Wanfang; Stewart,Scott G.; Wu,Xiao-Feng
    参考文献:Chimia 日期:2015 卷标:69(6) 页码:345-347]

    768-66-1 = 79-55-0
    反应条件:1.1 Reagents: Diphenylsilane Catalysts: 1,3-Bis(1,1-Dimethylethyl)-2,3-Dihydro-1H-1,3,2-Diazaphosphole Solvents: Acetonitrile-D3; -196 °C; 7 H,Rt
    标题:Hydrophosphination Of Co2 And Subsequent Formate Transfer In The 1,3,2-Diazaphospholene-Catalyzed N-Formylation Of Amines
    作者:Chong,Che Chang; Kinjo,Rei
    参考文献:Angewandte Chemie 日期:2015 卷标:54(41) 页码:12116-12120]

    768-66-1 = 79-55-0
    反应条件:1.1 Reagents: Trimethylamineborane Catalysts: 2-Amino-6-Methylpyridine Solvents: 1,2-Dichloroethane; 6 H,1 Atm,100 °C; 100 °C -> Rt1.2 Reagents: Ammonium Chloride Solvents: Water
    标题:Borane-Trimethylamine Complex As A Reducing Agent For Selective Methylation And Formylation Of Amines With Co2
    作者:Zhang,Yanmeng; Zhang,He; Gao,Ke
    参考文献:Organic Letters 日期:2021 卷标:23(21) 页码:8282-8286]

    768-66-1 = 79-55-0
    反应条件:1.1 Solvents: Benzene
    标题:Steric Hindrance To Formation Of Aminals From Di-Sec- And Di-Tert-Alkylamines
    作者:Kostyanovskii,R. G.; Shakhgel'Diev,M. A.; Nabiev,O. G.
    参考文献:Izvestiya Akademii Nauk Sssr 日期:1986 卷标:(12) 页码:2826-7]

    768-66-1 = 79-55-0
    反应条件:1.1 Reagents: Hydrogen Catalysts: Palladium Dihydroxide,Carbon Nitride (C3N4) Solvents: Methanol; 6 H,1.5 Mpa,30 °C
    标题:Underlying Mechanisms Of Reductive Amination On Pd-Catalysts: The Unique Role Of Hydroxyl Group In Generating Sterically Hindered Amine
    作者:Hong,Zeng; Ge,Xin; Zhou,Shaodong
    参考文献:International Journal Of Molecular Sciences 日期:2022 卷标:23(14)]

    768-66-1 = 79-55-0
    反应条件:1.1 Reagents: 9-Borabicyclo[3.3.1]Nonane Catalysts: 2-[[1,3-Bis[2,6-Bis(1-Methylethyl)Phenyl]-1,3-Dihydro-2H-Imidazol-2-Ylidene]Meth... Solvents: Toluene,Tetrahydrofuran; Rt; Rt -> 100 °C; 1.5 H,100 °C
    标题:Expanding The Ligand Framework Diversity Of Carbodicarbenes And Direct Detection Of Boron Activation In The Methylation Of Amines With Co2
    作者:Chen,Wen-Ching; Shen,Jiun-Shian; Jurca,Titel; Peng,Chun-Jung; Lin,Yen-Hsu; Et Al
    参考文献:Angewandte Chemie 日期:2015 卷标:54(50) 页码:15207-15212]

    768-66-1 = 79-55-0
    反应条件:1.1 Reagents: Poly(Methylhydrosiloxane) Catalysts: [1-[2,6-Bis(1-Methylethyl)Phenyl]-3,3-Diethyl-5,5-Dimethyl-2-Pyrrolidinylidene]C... Solvents: Butyl Ether; 18 H,80 °C; 80 °C -> Rt1.2 Solvents: Water; Rt
    标题:Cuh-Catalyzed Selective N-Methylation Of Amines Using Paraformaldehyde As A C1 Source
    作者:Wang,Diedie; Lang,Wanglv; Wang,Wan; Zou,Qizhuang; Yang,Chunliang; Et Al
    参考文献:Acs Omega 日期:2023 卷标:8(33) 页码:30640-30645]

    768-66-1 = 79-55-0
    反应条件:1.1 Solvents: Chloroform; Cooled; 96 H,Rt1.2 Reagents: Sodium Hydroxide Solvents: Water
    标题:Atom-Efficient Synthesis Of Alkynylfluoroborates Using Bf3-Based Frustrated Lewis Pairs
    作者:Iashin,Vladimir; Chernichenko,Konstantin; Papai,Imre; Repo,Timo
    参考文献:Angewandte Chemie 日期:2016 卷标:55(45) 页码:14146-14150]

    768-66-1 = 79-55-0
    反应条件:1.1 Reagents: Diphenylsilane Catalysts: 2254080-71-0 Solvents: Acetonitrile; 24 H,2.7 Atm,120 °C
    标题:Diverse Catalytic Reactivity Of A Dearomatized Pn3P*-Nickel Hydride Pincer Complex Towards Co2 Reduction
    作者:Li,Huaifeng; Goncalves,Theo P.; Zhao,Qianyi; Gong,Dirong; Lai,Zhiping; Et Al
    参考文献:Chemical Communications (Cambridge 日期:2018 卷标:54(81) 页码:11395-11398]

    768-66-1 = 79-55-0
    反应条件:1.1 Reagents: Poly(Methylhydrosiloxane) Catalysts: Tripotassium Phosphate,18-Crown-6 Solvents: Acetonitrile; 72 H,1 Atm,80 °C
    标题:Scalable Direct N-Methylation Of Drug-Like Amines Using 12Co2/13Co2 By Simple Inorganic Base Catalysis
    作者:Lu,Chunlei; Qiu,Zetian; Zhu,Yiling; Lin,Bo-Lin
    参考文献:Science Bulletin 日期:2019 卷标:64(11) 页码:723-729]

    771436-36-3 = 79-55-0
    反应条件:1.1 Reagents: Dimethylthiocarbamoyl Chloride Solvents: Dichloromethane; 3 H,Rt1.2 Solvents: Acetonitrile; Reflux
    标题:New Deoxygenation Method For Amine N-Oxides Using Dimethylthiocarbamoyl Chloride
    作者:Caliskan,Hafize; Zaim,Omer
    参考文献:Synthetic Communications 日期:2010 卷标:40(20) 页码:3078-3083]

    768-66-1 = 79-55-0
    反应条件:1.1 Reagents: Hydrogen Catalysts: Copper Nitrate Trihydrate,Zirconium Oxychloride Octahydrate,Tetrachloropalladic Acid Solvents: Octane; 48 H,160 °C
    标题:N-Methylation Of Amine And Nitro Compounds With Co2/h2 Catalyzed By Pd/cuzrox Under Mild Reaction Conditions
    作者:Cui,Xinjiang; Zhang,Yan; Deng,Youquan; Shi,Feng
    参考文献:Chemical Communications (Cambridge 日期:2014 卷标:50(88) 页码:13521-13524]

    768-66-1 = 79-55-0
    反应条件:1.1 Reagents: Diphenylsilane Catalysts: 1,3-Bis(1,1-Dimethylethyl)-2,3-Dihydro-1H-1,3,2-Diazaphosphole Solvents: Acetonitrile-D3; -196 °C; 12 H,50 °C
    标题:Formylation Or Methylation: What Determines The Chemoselectivity Of The Reaction Of Amine,Co2,And Hydrosilane Catalyzed By 1,3,2-Diazaphospholene?
    作者:Lu,Yu; Gao,Zhong-Hua; Chen,Xiang-Yu; Guo,Jiandong; Liu,Zheyuan; Et Al
    参考文献:Chemical Science 日期:2017 卷标:8(11) 页码:7637-7650]

    768-66-1 = 79-55-0
    反应条件:1.1 Reagents: Sodium Borohydride Solvents: 1,4-Dioxane; 10 Bar,Rt; Rt -> 100 °C; 24 H,100 °C; 100 °C -> Rt1.2 Solvents: Water; Rt
    标题:Catalyst-Free Selective N-Formylation And N-Methylation Of Amines Using Co2 As A Sustainable C1 Source
    作者:Zou,Qizhuang; Long,Guangcai; Zhao,Tianxiang; Hu,Xingbang
    参考文献:Green Chemistry 日期:2020 卷标:22(4) 页码:1134-1138
📜2,2,6,6-四甲基哌啶 反应生成 1,2,2,6,6-五甲基哌啶
参考文献:Reduction Of 4-Oxo-Tetraalkylpiperidines
标题:Reduction Of 4-Oxo-Tetraalkylpiperidines
摘要:4-氧代-2,2,6,6-四烷基哌啶及其n-烷基衍生物还原为4位未取代的2,2,6,6-四烷基哌啶的过程,其中在酸性介质中用催化活化的氢进行还原.

海关参考信息

专利信息


专利号:US-10925977-B2
优先权日:2006-10-05
标 题 :Efficient synthesis of chelators for nuclear imaging and radiotherapy: compositions and applications
发明人：YANG DAVID J; YU DONGFANG; THOMPSON ANDREW S
权利人:YANG DAVID J; YU DONGFANG; THOMPSON ANDREW S; CEIL POINT LLC; UNIV TEXAS
摘要:Novel methods of synthesis of chelator-targeting ligand conjugates, compositions comprising such conjugates, and therapeutic and diagnostic applications of such conjugates are disclosed. The compositions include chelator-targeting ligand conjugates optionally chelated to one or more metal ions. Methods of synthesizing these compositions in high purity are also presented. Also disclosed are methods of imaging, treating and diagnosing disease in a subject using these novel compositions, such as methods of imaging a tumor within a subject and methods of diagnosing myocardial ischemia.

专利号:US-RE41366-E
优先权日:2001-06-15
标 题 :Total synthesis of galanthamine, analogues and derivatives thereof
发明人：THAL CLAUDE; GUILLOU CATHERINE; BEUNARD JEAN-LUC; GRAS EMMANUEL; POTIER PIERRE
权利人:CT NAT DEL LA RECH SCIENT CNRS
摘要:The invention relates to a method for the synthesis of galanthamine, the derivatives and analogues thereof of formula (1) where R 1 =a hydrogen atom, R 2 =a hydroxy group, R 1 and R 2 together form â•?O, R 3 , R 4 , and R 5 independently=a hydrogen atom, a hydroxy group or a (C 1 -C 2 )alkoxy group, R 6 â•?H, (C 1 -C 12 )alkyl, (CH 2 ) n NR 7 R 8 , or —(CH 2 ) n N + R 7 R 8 R 9 where n=1 to 12, Z=two hydrogen atoms, or an oxygen atom and X=an oxygen, sulphur or nitrogen atom, or a —SO, —SO 2 , or —NR 6 group where R 6 is as defined above or is an amine protecting group.

专利号:US-11230560-B2
优先权日:2017-05-22
标题 :Synthesis of ETP derivatives
发明人：HORNE DAVID; XIE JUN
权利人:HOPE CITY
摘要:Provided herein, inter alia, is the synthesis of ETP derivatives. The synthetic methods described herein include converting a ring bridging trisulfide compound of formula n nto a ring bridging disulfide compound of formulan n nAlso provided herein are compositions comprising thereof.

专利号:US-9315483-B2
优先权日:2007-09-13
标题 :Synthesis of deuterated catechols and benzo[D][1,3]dioxoles and derivatives thereof
发明人：JONES ANDREW D; ZELLE ROBERT E; SILVERMAN I ROBERT
权利人:CONCERT PHARMACEUTICALS INC
摘要:The present invention provides a convenient and efficient process for the synthesis of d 2 -benzo[d][1,3]dioxoles.

专利号:US-2024327320-A1
优先权日:2023-02-06
标 题:Novel routes of chemical synthesis of 20s(oh)d3, 20s,25(oh)2d3, 20s,23s(oh)2d3, and 20s,23r(oh)2d3 and their modification of the immune activity of pbmcs
发明人：SLOMINSKI ANDRZEJ; BRZEMINSKI PAWEL; FABISIAK ADRIAN
权利人:UNITED STATE GOVERNMENT AS REPRESEN TED BY THE DEPT OF VETERANS AFFAIRS; UNIV OF WARSAW
摘要:The present disclosure is concerned with methods of making hydroxy derivatives of vitamin D3, compounds useful as intermediates in the preparation of the hydroxy derivatives, and methods of making the intermediates. This abstract is intended as a scanning tool for purposes of searching in the particular art and is not intended to be limiting of the present invention.

专利号:US-2018208775-A1
优先权日:2014-06-23
标 题:New aromatic macrocyclic metal complex dyes and the synthesis thereof with active nano metal powders
发明人：OLGUN UGURSOY; YILDIZ SALIH ZEKI
权利人:OLGUN UGURSOY; YILDIZ SALIH ZEKI
摘要:The present invention relates to a new type of inorganic coordination compound dyes having advanced technology optical, electronic and medical characteristics and relates to production of these dyes by means of new synthesis methods. The present invention relates to dyes which are metal (M: Li, Na, K, Mg, Ca, Sr, Ba, Ti, Zr, V, Cr, Mo, Mn, Re, Fe, Ru, Co, Rh, Ir, Ni, Pd, Pt, Cu, Ag, Au, Zn, Cd, B, Al, Ga, In, Si, Ge, Sn, Pb, Sb, Bi, Se, Te) complexes of aromatic macrocyclic compounds of the type Phtalocyanine (Pc), Naphtalocyanine (Nc), Porphyrazine (Pz), Porphyrin (Pr), sub-Phtalocyanine (subPc), sub-Naphtalocyanine (subNc), sub-Porphyrazine (subPz), sub-Porphyrine (subPr), and relates to the synthesis of these complexes and derivatives. The subject matter dyes can be used in solar cell photovoltaic (PV) panels, in OLEDS which are organic structured light emitting diodes, in polymers, in textile and in photodynamic therapy PDT applications. Moreover, industrial applications are possible which depend on strong fluorescence characteristics.

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主要参考文献


1: Somers K. Pempidine for Hypertension. Br Med J. 1961 Jan 7;1(5218):13-5. doi: 10.1136/bmj.1.5218.13.
2: Martin TJ, Suchocki J, May EL, Martin BR. Pharmacological evaluation of the antagonism of nicotine's central effects by mecamylamine and pempidine. J Pharmacol Exp Ther. 1990 Jul;254(1):45-51. 17(3):488-506. doi: 10.1111/j.1476-5381.1961.tb01136.x.
4: MUGGLETON DF, READING HW. Absorption, metabolism and elimination of pempidine in the rat. Br J Pharmacol Chemother. 1959 Jun;14(2):202-8. doi: 10.1111/j.1476-5381.1959.tb01384.x.

合成参考文献


摘要:Hirsch, A.; Vostrowsky, O., Science of Synthesis, (2008) 43, 54.
摘要:Li, Y.; Xie, W.; Jiang, X., Science of Synthesis Knowledge Updates, (2016) 2, 16.
摘要:Weibel, J.-M.; Blanc, A.; Pale, P., Science of Synthesis Knowledge Updates, (2018) 1, 59.
摘要:Palframan, M. J.; Parsons, A. F., Science of Synthesis, (2009) 48, 668.
摘要:Jux, N.; Montforts, F.-P.; Haake, E., Science of Synthesis Knowledge Updates, (2022) 1, 114.
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