CAS: 71989-26-9; (S)-2-((((9H-Fluoren-9-yl)Methoxy)Carbonyl)Amino)-6-((Tert-Butoxycarbonyl)Amino)Hexanoic Acid

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CAS号24424-99-5 二碳酸二叔丁酯 | CAS号657-27-2 L-赖氨酸盐酸盐 | CAS号2418-95-3 N(e)-B°C-L-赖氨酸 | CAS号82911-69-1 9-芴甲基-N-琥珀酰亚胺碳酸酯 | CAS号49557-75-7 铜肽 | CAS号198561-38-5 Na-Fm°C-Ne-B°C-... | CAS号86060-98-2 N-芴甲氧羰基-N'-叔丁氧羰... | CAS号4425-82-5 9-亚甲基-9H-芴 | CAS号2418-95-3 N(e)-B°C-L-赖氨酸 | CAS号69558-55-0 胸腺五肽 | CAS号75957-56-1 Thymopoietin II... | CAS号1207730-31-1 (6S,9S,12S,15S)... | CAS号1207730-30-0 (6S,9S,12S,15S)... | CAS号1026295-98-6 (S)-2-(2-((S)-2...

L-赖氨酸置于8-羟基喹啉,Copper(Ll) Sulfate Pentahydrate,Sodium Carbonate体系中,用 水,丙酮 作为反应溶剂,化学反应生成 N-Alpha-芴甲氧羰基-N-Epsilon-叔丁氧羰基-L-赖氨酸
参考文献:Tri-Peptide Cationic Lipids For Gene Delivery
标题:Tri-Peptide Cationic Lipids For Gene Delivery
摘要:一种新型的三肽阳离子脂质可以有效地将dna和sirna转运到小鼠的肿瘤细胞和肿瘤中,且在体外和体内毒性很小.
DOI:10.1039/c4Tb01312C

专利信息

专利号:US-2008287649-A1
优先权日:2006-12-29
标 题 :Methods for the synthesis of cyclic peptides
发明人：CHEN LIN; HAN YEUN-KWEI; ROBERTS CHRISTOPHER R
权利人:CHEN LIN; HAN YEUN-KWEI; ROBERTS CHRISTOPHER R
摘要:Methods for the synthesis of cyclic peptides are provided, as well as novel dipeptide compounds. The methods include the solid phase synthesis of a dipeptide, which is the coupled to a second peptide in a solid phase reaction. The peptide is then cyclized following the coupling reaction. The methods and dipeptides are particularly useful for the synthesis of MC-4 receptor agonist peptides.

专利号:WO-2024151344-A9
优先权日:2022-11-18
标题:A device that enables the combinatorial synthesis of small molecule libraries
发明人：COPELAND Gregory; LIU JANE
权利人:BRT BIOTECHNOLOGIES INC
摘要:A device for the synthesis of small molecules on a substrate is provided. The device includes a synthesis plate with vias, and a microfluidic patterning plate with a series ot open-faced channels that can be aligned with the vias on the synthesis plate. The device may be used to synthesize combinatorial libraries of small molecules.

专利号:US-2013267680-A1
优先权日:2010-09-15
标题:Total chemical synthesis of ubiquitin, ubiquitin mutants and derivatives thereof
发明人：OVAA HUIB; EL OUALID FARID; MERKX REMCO NICOLAAS SEBASTIAAN MICHEL
权利人:OVAA HUIB; EL OUALID FARID; MERKX REMCO NICOLAAS SEBASTIAAN MICHEL; STICHTING HET NL KANKERINST
摘要:The present invention relates to the field of total chemical synthesis of ubiquitin and related peptides. More in particular, a method is provided of solid phase synthesis of ubiquitin, ubiquitin mutants and derivatives thereof. It was the object of the present invention to provide an approach for the total chemical synthesis of ubuiqitin, which allows for the chemical synthesis of virtually any Ub mutant and giving high overall efficiency and purity. The present inventors have surprisingly found that this object can be realized with a method relying on incorporation of special amino acid building blocks. This approach was found to allow for exceptionally high yields of up to 14% and to provide an synthetic entry into virtually any ubiquitin derivative.

专利号:EP-1246837-B1
优先权日:2000-01-11
标 题:Oligomers of nonpeptide restricted mimetics of dipeptides or tripeptides and the use thereof in the synthesis of synthetic proteins and polypeptides
发明人：AMBLARD MURIEL; MARTINEZ JEAN; BERGE GILBERT
权利人:CENTRE NAT RECH SCIENT
摘要:The invention relates to nonpeptide oligomers of amino acids. The oligomers comprise -(NR'-A-CO)-O- units which represent a nonpeptide, restricted-mimetic inducer of the beta turn in a dipeptide or tripeptide fragment. Said oligomers may be produced by peptide synthesis techniques, whether in solution or in the solid phase, and can be used in the synthesis of synthetic proteins or polypeptides, in which the peptide fragment(s) (is) are identical to those of the corresponding natural protein or polypeptide and whose structural fragment(s) comprise(s) a fragment of an oligomer according to the invention.

专利号:US-2024067694-A1
优先权日:2021-01-04
标 题:Synthesis of teduglutide
发明人：GANGA RAMU VASANTHAKUMAR; PATIL NITIN; SUVARNA DEEPA SHANKAR
权利人:BIOCON LTD
摘要:The present invention provides for novel synthetic approach of solid phase synthesis of peptides with C-terminal Aspartic acid by anchoring the side chain carboxylic group of aspartic acid to the solid support to avoid the formation of various impurities and thus resulting in higher yield and ease the purification process. The present invention further provides the usage of free amino acids and reducing agents as antioxidants in the cleavage cocktail to negate the formation of oxidative impurities formed during the global cleavage and isolation of the peptide from solid support.

专利号:US-8722852-B2
优先权日:2006-04-28
标 题 :Cosmetic composition for stimulating the synthesis of proteins of the basement membrane
发明人：ZIEGLER HUGO; IMFELD DOMINIK; STOCKLI MARTIN; HEIDL MARC
权利人:ZIEGLER HUGO; IMFELD DOMINIK; STOCKLI MARTIN; HEIDL MARC; DSM IP ASSETS BV
摘要:Cosmetic composition which can be applied topically, comprising at least one compound of the general formula (I) in which R 1 is H, C 1 -C 20 -alkyl, cycloalkyl or aryl-C 1 -C 4 -alkyl, n is 1-4, X is —O—, —NH— or —NR 2 — and R 2 H or C 1 -C 20 -alkyl; and at least one compound corresponding to the above formula (I) but in which XR 1 with X having the possible meaning of —NH— is the residue of an alpha-amino acid; use of these compounds and of the composition for stimulating the synthesis of the proteins of the basement membrane; and also both those compounds of the formula (I) in which X is —NR 2 — and both R 1 and R 2 are different from H, and the compounds corresponding to formula (I) but in which XR 1 with X having the possible meaning of —NH— is the residue of an alpha-amino acid, as such.