愈创木酚碳酸酯置于sodium Hydroxide,硝酸体系中,化学反应生成 2-甲氧基-5-硝基苯酚 参考文献:Pollecoff; Robinson,Journal Of The Chemical Society,1918,Vol. 113,P. 651 标题:Pollecoff; Robinson,Journal Of The Chemical Society,1918,Vol. 113,P. 651
专利号:US-2004110228-A1 优先权日:2002-04-01 标 题:Combinatorial organic synthesis of unique biologically active compounds 发明人:MCALPINE SHELLI R; TAYLOR RACHEL E; BOLLA MEGAN L; SEGALL ANCA M 摘要:The invention provides a method for making a combinatorial library of cyclic compounds, such as Holliday junction-trapping compounds, comprising the steps of (a) obtaining a plurality of trimers according to the generic structure X 1- X 2- X 3 , wherein X 1 , X 2 and X 3 can be independently any naturally or nonnaturally occurring amino acids or peptidomimetics thereof; (b) optionally coupling a spacer S to the trimer at either end; (c) cyclizing two trimers or trimer-spacer conjugates in a head-to-tail orientation; thereby obtaining a combinatorial library of compounds, wherein the library does not include an unmodifed or naturally occurring Holliday Junction-trapping compounds. The invention additionally provides methods macrocyclic compounds that are synergimycin derivatives.
专利号:US-2010324266-A1 优先权日:2000-09-11 标题:Photocleavable Protecting Groups 发明人:BARONE ANTHONY D; MCGALL GLENN H 权利人:AFFYMETRIX INC 摘要:Novel compounds are provided, which are useful as linking groups in chemical synthesis, preferably in the solid phase synthesis of oligonucleotides and polypeptides. These compounds are generally photolabile and comprise protecting groups which can be removed by photolysis to unmask a reactive group. The protecting group has the general formula Y, wherein Y is a chemical structure as shown in FIG. 1 . Also provided is a method of forming, from component molecules, a plurality of compounds on a support, each compound occupying a separate predefined region of the support, using the protected compounds described above.
专利号:US-8067460-B2 优先权日:2004-10-04 标 题 :5-phenoxyalkoxypsoralens and methods for selective inhibition of the voltage gated Kv1.3 potassium channel 发明人:WULFF HEIKE; SANKARANARAYANAN ANANTHAKRISHNAN; HAENSEL WOLFRAM; SCHMITZ ALEXANDER; SCHMIDT-LASSEN KRISTINA 权利人:WULFF HEIKE; SANKARANARAYANAN ANANTHAKRISHNAN; HAENSEL WOLFRAM; SCHMITZ ALEXANDER; SCHMIDT-LASSEN KRISTINA; UNIV CALIFONIA 摘要:Compositions of matter comprising 5-phenoxyalkoxypsoralen compounds and their method of synthesis and use. The compounds are useable to treat diseases or disorders in human or animal subjects, including autoimmune diseases. The compounds inhibit potassium channels, including the Kv1.3 channel and at least some of the therapeutic effects of such compounds may be due at least in part to potassium channel inhibition. In some embodiments, the compounds are more selective for certain potassium channels (e.g., Kv1.3 channels) than other potassium channels (e.g., Kv1.5 channels).
专利号:US-7745490-B2 优先权日:2004-05-12 标题 :Substituted N-aryl benzamides and related compounds for treatment of amyloid diseases and synucleinopathies 发明人:SNOW ALAN D; NGUYEN BETH P; LAKE THOMAS P; CASTILLO GERARDO M; WEIGELE MANFRED 权利人:PROTEOTECH INC 摘要:Substituted n-aryl benzamides, related compounds and their pharmaceutically acceptable derivatives, their synthesis, pharmaceutical compositions containing them, and their use in the treatment of amyloid diseases, including Aβ amyloidosis, such as observed in Alzheimer's disease, IAPP amyloidosis, such as observed in type 2 diabetes, and synucleinopathies, such as observed in Parkinson's disease, and the manufacture of medicaments for such treatment are provided.
专利号:WO-2022018767-A1 优先权日:2020-07-24 标题 :Agrochemical composition comprising sdhi fungicides. 发明人:PATEL Dipakkumar; SHAH KENAL V; SHAH BHAVESH V; DABHODIA KAWARLAL 权利人:RAJDHANI PETROCHEMICALS PRIVATE LTD 摘要:Agrochemical composition comprising SDHI fungicides. The present invention further relates to a synergistic fungicidal compositions comprising bioactive amounts of a fungicide selected from SDHI (Succinate dehydrogenase inhibitors) group or mixture thereof; at least one more fungicide selected from the class of QoI (Quinone outside Inhibitors), QiI-fungicides (Quinone inside Inhibitors), Lipid or transport and membrane synthesis inhibitors, Sterol biosynthesis Inhibitors, Melanin synthesis in cell wall Inhibitors, compound with unknow mode of action, multisite contact fungicides, Ipflufenoquin, Pyridachlometyl or mixture thereof; at least one more compound selected from plant health additive or mixture thereof. The present invention further relates to process for preparing the said compositions in specific ratio. The present invention further relates to the process for preparing the said composition along with at least one inactive excipient; and formulations thereof. The present invention further relates to the synergistic agrochemical fungicidal compositions, wherein active ingredient present in fixed ratio shows synergy in fungicidal activity.
专利号:US-2008242662-A1 优先权日:2005-05-31 标题 :Organic Compounds 发明人:NIHONYANAGI ATSUKO; TOYAO ATSUSHI; IWAKI YUKI; MASUYA KEIICHI 权利人:NIHONYANAGI ATSUKO; TOYAO ATSUSHI; IWAKI YUKI; MASUYA KEIICHI 摘要:The invention relates to substituted 3,4- or higher substituted piperazine compounds, the use thereof for the preparation of a pharmaceutical formulation for the treatment of a disease that depends on activity of renin; the use of a compound of that class in the treatment of a disease that depends on activity of renin; these compounds for use in the diagnostic and therapeutic treatment of a warm-blooded animal, especially for the treatment of a disease (=disorder) that depends on activity of renin; pharmaceutical formulations or products comprising said compounds, and/or a method of treatment comprising administering said compounds, a method for the manufacture of said compounds as well as novel intermediates, starting materials and/or partial steps for their synthesis. The compounds are especially of the formula I, n n n n n n n n n n wherein R1, R2, R11, C, E and D are as defined in the specification.
[参考文献]: Nenad Manevski, Et Al. Phase Ii Metabolism In Human Skin: Skin Explants Show Full Coverage For Glucuronidation, Sulfation, N-Acetylation, Catechol Methylation, And Glutathione Conjugation. Drug Metab Dispos. 2015 Jan;43(1):126-39.
合成参考文献
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