4-异丙基苄氯置于sodium Tungstate 4 Angstroem Ms,三辛基甲基硫酸铵体系中,化学反应 18.0H,以61%的收率获得产物4-异丙基苯甲酸 参考文献:Oxidation Of Benzyl Chlorides And Bromides To Benzoic Acids With 30 Hydrogen Peroxide In The Presence Of Na2Wo4,Na2Vo4,Or Na2Moo4 Under Organic Solvent-Free Conditions 标题:Oxidation Of Benzyl Chlorides And Bromides To Benzoic Acids With 30 Hydrogen Peroxide In The Presence Of Na2Wo4,Na2Vo4,Or Na2Moo4 Under Organic Solvent-Free Conditions 摘要: DOI:10.1021/jo001796N
专利号:US-2018105838-A1 优先权日:2015-03-11 标 题:Process for de novo microbial synthesis of terpenes 发明人:SCHRADER JENS; BUCHHAUPT MARKUS; SONNTAG FRANK; KRONER CORA; BRÜSER HEIKE; Schröder Hartwig; PELZER RALF 权利人:BASF SE 摘要:The invention relates to microbial terpene production. Known methods for microbial production of terpenes are mostly based on the direct conversion of sugars. Therefore alternative substrates, in particular alternative carbon sources, for use in microbial terpene production were desirable. The invention relates to a methylotrophic bacterium containing recombinant DNA coding for at least one polypeptide with enzymatic activity for heterologous expression in said bacterium, wherein said at least one polypeptide with enzymatic activity is selected from the group consisting an enzyme of a heterologous mevalonate pathway, a heterologous terpene synthase and optionally a heterologous synthase of a prenyl diphosphate precursor. The invention further relates in particular to a method for de novo microbial synthesis of sesquiterpenes or diterpenes from methanol and/or ethanol.
专利号:WO-0112791-A1 优先权日:1999-08-12 标 题 :Dna shuffling of dioxygenase genes for production of industrial chemicals 发明人:SELIFONOV SERGEY A; NEWMAN LISA M 权利人:MAXYGEN INC; SELIFONOV SERGEY A; NEWMAN LISA M 摘要:This invention provides improved polypeptides, including dioxygenases, dehydrogenases, ligases and transferases that are useful for the biocatalytic synthesis of compounds such as α-hydroxycarboxylic acids, and aryl- and alkyl-hydroxy and carboxylic acid compounds. The polypeptides provided herein are improved in properties such as regioselectivity, enzymatic activity, stereospecificity, and the like. Methods for obtaining recombinant polynucleotides that encode these improved polypeptides are also provided, as are organisms that express the polypeptides and are thus useful for carrying out said biocatalytic syntheses. Also provided by the invention are methods for increasing said solvent resistance of organisms that are used in the synthetic methods.
专利号:US-6664282-B2 优先权日:1999-09-17 标 题:Synthesis of [3,5,7]-1H-imidazo [1,5-a]imidazol-2 (3H)- one compounds 发明人:ELABDELLAOUI HASSAN M; OSTRESH JOHN M; HOUGHTEN RICHARD A 权利人:TORREY PINES INST 摘要:Individual substituted [3,5,7]-1H-imidazo[1,5-a]imidazol-2(3H)-one compounds and their pharmaceutically-acceptable salts are disclosed, as are libraries of such compounds. Methods of preparing and using the libraries of compounds as well as individual compounds of the libraries are also disclosed.
专利号:US-2021163969-A1 优先权日:2018-08-06 标 题:Combined transcription and translation platform derived from plant plastids and methods for in vitro protein synthesis and prototyping of genetic expression in plants 发明人:JEWETT MICHAEL CHRISTOPHER; CLARK LAUREN; VOIGT CHRISTOPHER A; MAJER ESZTER 权利人:UNIV NORTHWESTERN; MASSACHUSETTS INST TECHNOLOGY 摘要:Disclosed are compositions, methods, and kits for performing cell-free protein synthesis (CFPS). The disclosed compositions, methods, and kits include or utilize components prepared from plant plastids or extracts thereof. The compositions, methods, and kits may be used for in vitro protein synthesis and prototyping of genetic expression in plants and are suitable for automation.
专利号:US-5856107-A 优先权日:1997-02-04 标 题 :Combinatorial libraries of imidazol-pyrido-indole and imidazol-pyrido-benzothiophene derivatives, methods of making the libraries and compounds therein 发明人:OSTRESH JOHN M; HOUGHTEN RICHARD A 权利人:TREGA BIOSCIENCES INC 摘要:The invention provides a rapid approach for combinatorial synthesis and screening of libraries of imidazol-pyrido-indole and imidazol-pyrido-benzothiophene compounds. The present invention further provides methods of preparing the libraries and the individual compounds made by the combinatorial synthesis.
专利号:WO-9834113-A1 优先权日:1997-02-04 标题 :Combinatorial libraries of bicyclic guanidine derivatives and compounds therein 发明人:OSTRESH JOHN M; MEYER JEAN-PHILIPPE; DOOLEY COLETTE T; HOUGHTEN RICHARD A; BLONDELLE SYLVIE E; SCHONER CHRISTA C 权利人:TREGA BIOSCIENCES INC 摘要:The invention provides a rapid approach for combinatorial synthesis and screening of combinatorial libraries of bicyclic guanidine compounds. The present invention further provides the compounds made by the combinatorial synthesis and individually as well as methods of using the same.
摘要:Summary Tables of Biological Tests, National Research Council Chemical-Biological Coordination Center., 6(215), 1954 摘要:R. Y. Levina, P. A. Gembitskii, L. P. Guseva and P. K. Agasyan, J. Gen. Chem. USSR (Engl. Transl.) 34, 144 (1964). 摘要:Y. S. Shabarov, V. K. Potapov and R. Y. Levina, J. Gen. Chem. USSR (Engl. Transl.) 34, 2865 (1964). 摘要:Y. S. Shabarov, T. P. Surikova and R. Y. Levina, J. Org. Chem. USSR (Engl. Transl.) 4, 1131 (1968).