CAS: 50643-20-4; Phosphoric Acid Mono-(2-Hexadecyloxy-Ethyl) Ester

📜α-氢化-ω-羟基异十六烷醇聚(氧-1,2-乙烷二基)置于三乙胺,三氯氧磷体系中,用 四氢呋喃 作为反应溶剂,化学反应 0.17H,反应生成 聚乙二醇十六烷基醚磷酸酯
参考文献:Alkyl And Alkoxyethyl Antineoplastic Phospholipids
标题:Alkyl And Alkoxyethyl Antineoplastic Phospholipids
摘要:Two Series Of Phosphodiester Ether Lipid Analogs With (N-Methylmorpholino)Ethyl Or (N-Methylpiperidino)Ethyl Polar Head Groups And Long Aliphatic Or Alkoxyethyl Chains In The Nonpolar Portion Of The Molecule Were Synthesized As Potential Antineoplastic Agents. The Cytotoxic Activity Of These Compounds (9-19) Was Evaluated In Vitro Against A Panel Of Six Human Tumor Xenografts And In Two Biochemical,Mechanism-Based Screens (Cdc2 Kinase And Cdc25 Phosphatase). Analogs 13,14,17,And 19 Showed Activity In The In Vitro Tests. Specifically,14 And 17 Were More Active Than The Reference Compound Hexadecylphosphocholine (Miltefosine,He-Pc) While 13 And 19 Possessed Activity Similar To That Of The Control. Of The Analogs Tested The One With The Highest Potency And Least Toxicity (17) Has An N-Methylpiperidino Head Group And A C-16 Alkyl Chain. In The Mechanism-Based Tests 11 Showed Weak Inhibitory Activity In The Cdc25 Phosphatase Screen.
DOI:10.1021/jm9509152