CAS: 4994-86-9; 4-Chloro-2-Methylpyrimidine

该化合物是一种杂交有机化合物,其特点是一个有六人组成的芳香环,含有1号站点和3号站点的两个氮原子;4号站点存在氯原子,2号站点存在一个甲基组,其独特的化学特性是氯原子,该化合物一般看起来无色,可粉黄液体或固体,视其物理状态而定;在乙醇和乙醚等有机溶剂中可溶解,但水溶性有限. 4-Chroloo-2-甲基胺在制药和农用化学品中的用途是众所周知的,通常作为各种生物活性化合物合成的中间体,其再活动受氯原子的电阻特性影响,可参与核糖替代反应.此外,该化合物可能表现出抗微生物和乙酰的特性,使其在药用化学和农业应用中都具有兴趣.应当观察适当的处理和安全措施,因为其具有毒性.

英文名称4-Chloro-2-Methylpyrimidine
中文名称4-氯-2-甲基嘧啶
IUPAC名称4-chloro-2-methylpyrimidine
其它别名2-甲基-4-氯嘧啶; Nsc 165514; Pyrimidine, 4-Chloro-2-Methyl- (7Ci,8Ci,9Ci)
CAS编号4994-86-9
MFCD编号:MFCD00234069
EINECS号:800-409-1
分子式:C5H5ClN2
分子量:128.56
产品CID: 1485982
产品分类有机原料→分子砌块→芳杂环类化合物→嘧啶类化合物

相似结构搜索
产品信息参考
InChIKey: WDTVJRYCMIZPMX-UHFFFAOYSA-N
InChI=1S/C5H5ClN2/c1-4-7-3-2-5(6)8-4/h2-3H,1H3…
计算化学: 氢键受体数2.0氢键供体数0可旋转键数0

相似化合物

1780-26-3 898044-48-9 1272758-33-4

MSDS等安全信息

GHS象形图
GHS符号GHS07 & GHS05;
注释: Exclamation mark & Corrosion
危险类别急性毒性类别4(经口)
特定目标器官毒性 - 单次接触类别3
皮肤腐蚀/刺激类别2
严重眼损伤类别1
严重眼刺激类别2
警示词Danger(危险)
危险描述H302 |吞咽有害.
H335 |可能引起呼吸道刺激.
H315 |造成皮肤刺激.
H318 |造成严重眼损伤.
H319 |造成严重眼刺激.
防范说明P264-P270-P330-P501
危险品标志Xi

欧盟法规

ECHA物质C&L通报

上下游产品

合成工艺路线路线简述

Alkaline Earth Salt Of/the/ Methylsulfuric Acid置于三氯氧磷体系中,化学反应生成 4-氯-2-甲基嘧啶
参考文献:Gabriel,Chemische Berichte,1904,Vol. 37,P. 3641
标题:Gabriel,Chemische Berichte,1904,Vol. 37,P. 3641

专利信息

专利号:US-8242273-B2
优先权日:2005-07-28
标题:Synthesis of 4/5-pyrimidinylimidazoles via sequential functionalization of 2,4-dichloropyrimidine
发明人：DENG XIAOHU; MANI NEELAKANDHA
权利人:DENG XIAOHU; MANI NEELAKANDHA; JANSSEN PHARMACEUTICA NV
摘要:This invention relates to methods of making pyrimidinyl-substituted imidazole compounds by sequential substitution of the 4- and 2-chloro groups of 2,4-dichloropyrimidine, nucleophilic substitution to form pyrimidinylalkyne derivatives, oxidation to the corresponding 1,2-diketones, and cyclocondensation reactions.

专利号:US-2010274015-A1
优先权日:2005-07-28
标题:Synthesis of 4/5-pyrimidinylimidazoles via sequential functionalization of 2,4-dichloropyrimidine

专利号:US-2007027319-A1
优先权日:2005-07-28
标题 :Synthesis of 4/5-pyrimidinylimidazoles via sequential functionalization of 2,4-dichloropyrimidine

专利号:US-8124765-B2
优先权日:2005-07-28
标题 :Synthesis of 4/5-pyrimidinylimidazoles via sequential functionalization of 2,4-dichloropyrimidine

专利号:US-7807832-B2
优先权日:2005-07-28
标题 :Synthesis of 4/5-pyrimidinylimidazoles via sequential functionalization of 2,4-dichloropyrimidine

专利号:US-6936600-B2
优先权日:1999-04-01
标题:Sorbitol dehrydrogenase inhibitors
发明人：CHU-MOYER MARGARET Y; MYLARI BANAVARA L; ZEMBROWSKI WILLIAM J
权利人:PFIZER
摘要:This invention is directed to sorbitol dehydrogenase inhibitory compounds of the formula I, n n nwherein R 1 , R 2 and R 3 are as defined in the specification. This invention is also directed to pharmaceutical compositions containing those compounds and methods of treating or preventing diabetic complications, particularly diabetic neuropathy, diabetic nephropathy, diabetic microangiopathy, diabetic macroangiopathy and diabetic cardiomyopathy by administering such compounds to a mammal suffering from diabetes and therefore at risk for developing such complications. This invention is also directed to pharmaceutical compositions comprising a combination of a compound of formula I of this invention with an aldose reductase inhibitor and to methods of treating or preventing diabetic complications therewith. This invention is also directed to pharmaceutical compositions comprising a combination of a compound of formula I of this invention with an NHE-1 inhibitor and to methods of treating cardiomyopathy and other heart-related problems therewith. This invention is also directed to certain intermediates used in the synthesis of the compounds of formula I and to processes for preparing those intermediates.