CAS: 436799-34-7; 3,5-Dibromo-2-Iodopyridine

该化合物是一种卤化的衍生物,广泛用作有机合成和制药研究的多种中间体.其独特的替代模式,分别以3-5和2个位置的溴原子和碘原子为特征,增强了其在交叉反应中的回动性,如铃木和松木木木草交配,能够高效地实现功能化.该化合物的高度纯度和稳定性使它适合精确的合成应用,包括生物活性分子和先进材料的开发.其结构特性还有利于重新作选择的修改,为研究人员提供了复杂的热循环框架的可靠建筑块.建议由于对光和湿度的敏感性,在高温条件下进行适当处理.

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408502-43-2 823221-97-2 1256806-95-7

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上下游产品

2-amino-3,5-dibromopyridine 2,3,5-tribromopyridine 3,5-dibromopyridine 3,5-dibromo-2-(trifluoromethyl)pyridine

合成工艺路线路线简述

    📜3,5-二溴吡啶置于n-Tetramethylpiperidine Magnesium Chloride,Lithium Chloride,碘体系中,用 四氢呋喃 作为反应溶剂,化学反应 0.5H,以89%的收率获得产物3,5-二溴-2-碘吡啶
    参考文献:R2Nmgcl.Licl类型的混合mg / Li酰胺是高效区域性选择性反应生成功能化芳基和杂芳基镁化合物的碱.
    标题:R2Nmgcl.Licl类型的混合mg / Li酰胺是高效区域性选择性反应生成功能化芳基和杂芳基镁化合物的碱.
    摘要:
    DOI:10.1002/anie.200504024

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    专利信息


    专利号:US-7884125-B2
    优先权日:2008-04-30
    标 题:Straightforward entry to 7-azabicyclo[2.2.1]heptane-1-carbonitriles and subsequent synthesis of epibatidine analogues
    发明人：STEVENS CHRISTIAN; HEUGEBAERT THOMAS
    权利人:UNIV GENT
    摘要:The present invention relates to a group of substituted-7-azabicyclo-[2.2.1]heptyl derivatives with biological activity. The present invention also relates to synthetic methods for producing said substituted-7-azabicyclo-[2.2.1]heptyl derivatives. The present invention also relates to certain intermediates for producing such substituted-7-azabicyclo-[2.2.1]heptyl derivatives, as well as a synthetic method for producing such intermediates. The present invention also relates to pharmaceutical compositions comprising such substituted-7-azabicyclo-[2.2.1]heptyl derivatives, as well as their use as medicaments for the treatment of diseases mediated by a Nicotinic Acetylcholine Receptor or a receptor being a member of the Neurotransmitter-gated Ion Channel Superfamily, such as pain, Alzheimer's disease, Parkinson's disease, schizophrenia, epilepsy and nicotine addiction.

    专利号:US-2009275616-A1
    优先权日:2008-04-30
    标 题 :Straightforward entry to 7-azabicyclo[2.2.1]heptane-1-carbonitriles and subsequent synthesis of epibatidine analogues

    专利号:CN-102911114-A
    优先权日:2012-11-22
    标题:Synthesis of 3,5-Dibromo-4-iodopyridine Catalyzed by Alkyl Silicon Reagent

    专利号:CN-102911114-B
    优先权日:2012-11-22
    标 题:Synthesis of 3,5-Dibromo-4-iodopyridine Catalyzed by Alkyl Silicon Reagent

    专利号:CN-102898359-A
    优先权日:2012-11-12
    标题:Synthesis of 3,5-dibromo-4-iodopyridine

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    合成参考文献

    参考DOI号:10.1002/anie.200504024
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