CAS: 4226-01-1; Tri-N-Butyltin Lithium

📜六正丁基二锡置于正丁基锂体系中,用 四氢呋喃,正己烷 作为反应溶剂,化学反应 0.5H,反应生成 三丁基锡锂
参考文献:对 Fidaxomicin 的趋同方法:完全糖基化的北部和南部片段的合成
标题:对 Fidaxomicin 的趋同方法:完全糖基化的北部和南部片段的合成
摘要:需要能够合成天然产物抗生素类似物的有效方法,以跟上病原生物多重抗性菌株的出现.该领域的一个有前途的候选药物是非达霉素,它在体外令人印象深刻具有抗结核活性,但全身生物利用度差.我们为该目标设计了灵活的合成路线,以探索新的化学空间和具有卓越药代动力学的类似物的未来开发.我们为每个关键的大环和糖片段开发了一种稳健的方法,它们通过立体选择性糖基化结合,以及具有完全糖基化片段的收敛后期大环内酯形成.尽管我们能够证明最终的 Suzuki 交叉偶联和闭环复分解步骤能够在存在北部间苯二甲酸鼠李糖苷和南部新糖苷糖的情况下形成大环,但这些最终步骤因产量低和形成不需要的z-大环作为主要立体异构体.
DOI:10.1016/j.Tet.2020.131673

专利信息

专利号:US-11279672-B2
优先权日:2018-04-18
标题:Asymmetric synthesis of alpha-branched chiral amines
发明人：LELETI RAJENDER REDDY; KOTTURI SHARADSRIKAR; WAMAN YOGESH; PATEL CHIRAG; PATWA ADITYA; SHENOY RAJESH
权利人:PIRAMAL PHARMA LTD
摘要:The present invention relates to an improved asymmetric synthesis of alpha-branched amines (hereafter referred to as the compound) and relative chiral amines (1″) or its pharmaceutically acceptable salt and derivatives. The process comprises an unusual substrate specific regioselective ortho lithiation of substituted arene compounds, followed by its highly diastereoselective addition to N-tert-butanesulfinylimines resulting in the selective formation of alpha-branched sulfinyl amine and chiral amine; which on subsequently removing the sulfinyl group provides corresponding alpha-branched amines or relative chiral amines (1″).

专利号:US-8933181-B2
优先权日:2006-10-06
标题:Branched polymers and methods for their synthesis and use
发明人：MOURI HIROSHI; LUO STEVEN; KURASCH JESSICA; ROBERTSON CHRISTOPHER G; WARREN SANDRA
权利人:MOURI HIROSHI; LUO STEVEN; KURASCH JESSICA; ROBERTSON CHRISTOPHER G; WARREN SANDRA; BRIDGESTONE CORP
摘要:Branched polymers including multi-branched polymers, functionalized branched polymers, star-branched polymers, and dendigraft polymers. Methods for the synthesis of branched polymers and method for the use of branched polymers in tire components are also included.

专利号:US-4617409-A
优先权日:1984-06-29
标题 :Aminomethyltriorganotin compounds, preferably α-mono or disubstituted; and the method of preparation
发明人：ELISSANDO BERNARD; PEREYRE MICHEL; QUINTARD JEAN-PAUL
权利人:CENTRE NAT RECH SCIENT
摘要:The invention concerns a method of preparation of aminomethyltriorganotin compounds, preferably α-mono or disubstituted, the new tin compounds obtained thereby and an application of said tin compounds to the synthesis of aminomethylorganometallic compounds and to the regiospecific preparation of β-aminoalcohols. The intermediate tin and metallic compounds are new. The method for preparing the tin compounds comprises reacting an iminium salt with a corresponding stannylanion, preferably a triorganostannylanion. This method provides best yields and provides regiospecific β-aminoalcohols useful by having in most cases a large spectrum of pharmacological activities.

专利号:US-5877336-A
优先权日:1996-12-31
标题 :Synthesis of tributyltin lithium
发明人：HERGENROTHER WILLIAM L; BETHEA TRISTRAM W
权利人:BRIDGESTONE CORP
摘要:Triorgano substituted-tin lithium initiators are made in a dimethyl ether solvent. The substitution of dimethyl ether as the solvent for the traditional tetrahydrofuran solvent results in an initiator for anionic polymerizations that can produce less 1,2-vinyl repeat units. The dimethyl ether is also easier to remove from the polymerization media because it has a boiling point at one atmosphere of minus 24.8° C. and thus is a gas at 25° C.

专利号:WO-2009006434-A1
优先权日:2007-06-29
标题:One-pot synthesis of nanoparticles and liquid polymer for rubber applications

专利号:RU-2501731-C2
优先权日:2007-06-29
标题 :Monoreactor synthesis of nanoparticles and liquid polymer for fields of caoutchouc application