CAS: 39827-11-7; Benzo[b]Thiophene-2-Carbonyl Chloride

上下游产品

苯并噻吩-2-羧酸 Benzo[b]Thiophene-2-Carboxylic Acid 6314-28-9

苯并噻吩-2-羧酸置于氯化亚砜体系中,化学反应生成 苯并噻吩-2-羰酰氯
参考文献:Novel Methylselenoesters As Antiproliferative Agents
标题:Novel Methylselenoesters As Antiproliferative Agents
摘要:硒(se)化合物在癌症治疗中具有潜在的治疗作用.重要的是,硒化合物的生物效应是通过其代谢产物发挥的,其中甲基硒醇(ch3Seh)是一个关键的执行者.在本研究中,我们开发了一系列具有不同骨架的甲基硒酯,旨在调节ch3Seh的释放.这十五种化合物遵循lipinski的五规则,并且除了化合物1和14外,其药物相似性值均优于阳性对照甲基硒酸.对这些化合物进行了自由基清除活性评估,其中化合物11能减少dpph和abts自由基.在五种癌细胞系(前列腺,结肠和肺癌,乳腺腺癌和慢性髓性白血病)和两种非恶性细胞系(肺和乳腺上皮)中评估了这些化合物的细胞毒性.十种化合物在72小时内在四种癌细胞系中gi50值低于10 μm.由于与甲基硒酸的相似性,化合物5和15被选为进一步在乳腺腺癌细胞系中进行作用机制表征.这两种化合物均诱导g2/m期阻滞,而细胞死亡部分通过caspase介导.还研究了它们的还原和代谢,这两种化合物都被证明是还原型酶硫氧还蛋白还原酶的底物.
DOI:10.3390/molecules22081288

专利信息

专利号:EP-2918579-A1
优先权日:2014-03-14
标题 :Synthesis of 2-arylmethyl-5-aryl-thiophene
权利人:LEK PHARMACEUTICALS
摘要:The present invention provides a new synthetic process for the production of 2-arylmethyl-5-aryl-thiophene, an intermediate in the synthesis of C-aryl glycosides.

专利号:US-6664410-B1
优先权日:1999-07-15
标题 :Solid phase nitrile synthesis
发明人：KOBYLECKI RYSZARD; HONE NEAL DAVID; PAYNE LLOYD JAMES
权利人:MILLENNIUM PHARMACEUTICALS LTD
摘要:A nitrile compound is prepared by treating a solid supported amide to dehydrate it and cleave it from the support in one operation. The preparation involves acetylation of the amide compound in the presence of a base at a temperature of less than 100° C.

专利号:EP-0731800-A1
优先权日:1993-12-03
标题:IMPROVED PROCESS FOR THE SYNTHESIS OF 3-CHLOROBENZO [b]THIOPHENE-2-CARBONYL CHLORIDES

专利号:US-7250410-B2
优先权日:2001-06-07
标题:Cyclic nucleotide phosphodiesterase inhibitors, preparation and uses thereof
发明人：BOURGUIGNON JEAN-JACQUES; LAGOUGE YAN; LUGNIER CLAIRE; KLOTZ EVELINE; MACHER JEAN-PAUL; RABOISSON PIERRE; SCHULTZ DOMINIQUE
权利人:VIA PHARMACEUTICALS INC
摘要:The invention concerns novel benzodiazepine derivatives and their uses in the field of therapeutics particularly for treating pathologies involving the activity of a cyclic nucleotide phosphodiesterase. It also concerns methods for preparing them and novel synthesis intermediates. The inventive compounds more particularly correspond to general formula (I):

专利号:US-8242142-B2
优先权日:2008-08-19
标题:Cyclohexylamines, phenylamines and uses thereof
发明人：LIN SHUO; YANG ZHEN
权利人:LIN SHUO; YANG ZHEN; UNIV CALIFORNIA; UNIV PEKING SHENZHEN GRAD SCHO
摘要:Compounds having the formula I, their methods of synthesis, and pharmaceutically acceptable salts of certain of them are provided in which the variables have the definitions described herein. n n n n n n n n n n Compositions including the compounds having the formula I-A in which the variables have the definitions described herein, and methods of using the compositions for the treatment of certain diseases mediated by the up-regulation of Smo are also disclosed.

专利号:US-7648986-B2
优先权日:2002-01-10
标题:Substituted thieno[3,2-D]pyrimidines as Rho kinase inhibitors
发明人：NAGARATHNAM DHANAPALAN; KHIRE UDAY; ASGARI DAVOUD; SHAO JIANXING; LIU XIAO-GAO; WANG CHUNGUANG; HART BARRY; WEBER OLAF; LYNCH MARK; ZHANG LEI; WANG LEI
权利人:BAYER HEALTHCARE LLC
摘要:Disclosed are compounds and derivatives thereof their synthesis, and their use as Rho-kinase inhibitors. These compounds of the present invention are useful for inhibiting tumor growth, treating erectile dysfunction, and treating other indications mediated by Rho-kinase, e.g., coronary heart disease.