CAS: 372-66-7; 6-Amino-2-Methylheptan-2-Ol

该化合物是一种合成心脏刺激剂和血管血管调节器,主要用于改善冠状血液流动,增强心肌功能.化学结构为6-氨-2-甲基-2-七氯硝醇,具有非热带和甲状腺效应,有助于处理轻微心衰竭和减退.通过直接刺激乙型肾上腺受体,同时促进外围血管血管变异,增加心脏输出的复合作用.七氨基甲醇因其平衡的血动活动而得到重视,其心脏增心率得到适度提高,而没有过度的压强效应.其代谢稳定性和可预测的药性动能有助于其临床在心血管辅助疗法中的用途.该产品通常通过口头或静脉注射方式进行,取决于治疗环境.

结构式图片

欧盟法规

ECHA物质ECHA物质C&L通报REACH预注册

上下游产品

CAS号165962-54-9 (6R)-6-amino-2-... | CAS号90227-28-4 2-Heptanone, 6-... | CAS号110-93-0 甲基庚烯酮 | CAS号1118-51-0 3-[(6-hydroxy-6... | CAS号165962-54-9 (6R)-6-amino-2-... | CAS号1100754-09-3 N-(((S)-6-hydro... | CAS号1100753-90-9 N-(((R)-6-hydro... | CAS号85602-77-3 N-(6-hydroxy-6-...

合成工艺路线路线简述

  • 合成目标产物 6-Amino-2-Methyl-2-Heptanol 主要起始原料 6-Methyl-5-Hepten-2-One
  • (文献来源)合成步骤主要原料 6-Methyl-5-Hepten-2-One
📜(R)-6-Amino-2-Methylheptan-2-Ol置于2,2,2-三氟乙硫醇体系中,用 四氢呋喃,3-甲基-3-戊醇 作为反应溶剂,化学反应 2.0H,反应生成 6-氨基-2-甲基-2-庚醇
参考文献:En Route To (S)-Selective Chemoenzymatic Dynamic Kinetic Resolution Of Aliphatic Amines. One-Pot Kr/racemization/kr Sequence Leading To (S)-Amides
标题:En Route To (S)-Selective Chemoenzymatic Dynamic Kinetic Resolution Of Aliphatic Amines. One-Pot Kr/racemization/kr Sequence Leading To (S)-Amides
摘要:A One-Pot Sequential Process,Involving A Radical Racemization And An Enzymatic Resolution,Provides Access To (S)-Amides,From Racemic Amines,With Ee And Yields Ranging From 78 To 94% And 58 To 80%,Respectively.
DOI:10.1021/jo900074W

海关参考信息

专利信息


专利号:US-10925977-B2
优先权日:2006-10-05
标 题 :Efficient synthesis of chelators for nuclear imaging and radiotherapy: compositions and applications
发明人:YANG DAVID J; YU DONGFANG; THOMPSON ANDREW S
权利人:YANG DAVID J; YU DONGFANG; THOMPSON ANDREW S; CEIL POINT LLC; UNIV TEXAS
摘要:Novel methods of synthesis of chelator-targeting ligand conjugates, compositions comprising such conjugates, and therapeutic and diagnostic applications of such conjugates are disclosed. The compositions include chelator-targeting ligand conjugates optionally chelated to one or more metal ions. Methods of synthesizing these compositions in high purity are also presented. Also disclosed are methods of imaging, treating and diagnosing disease in a subject using these novel compositions, such as methods of imaging a tumor within a subject and methods of diagnosing myocardial ischemia.

专利号:US-10040752-B2
优先权日:2015-08-24
标 题 :Synthesis of levomethadone hydrochloride or dextromethadone hydrochloride and methods for use thereof
发明人:MKRTCHYAN GNEL; YAO QINGWEI
权利人:CODY LABORATORIES INC
摘要:Highly efficient methods for synthesis of levomethadone hydrochloride or dextromethadone hydrochloride are provided starting from D-alanine, or L-alanine, respectively, with retention of configuration. Methods for treating a subject are provided comprising administering a composition comprising an effective amount of levomethadone hydrochloride having not more than 10 ppm dextromethadone.

专利号:US-2019002394-A1
优先权日:2015-08-24
标 题 :Synthesis of levomethadone hydrochloride or dextromethadone hydrochloride and methods for use thereof

专利号:KR-101513003-B1
优先权日:2006-10-05
标 题 :Efficient synthesis of chelators for nuclear imaging and radiotherapy compositions and applications

专利号:US-10814013-B2
优先权日:2006-10-05
标 题 :Efficient synthesis of chelators for nuclear imaging and radiotherapy: compositions and applications

专利号:AU-2007308022-A2
优先权日:2006-10-05
标题 :Efficient synthesis of chelators for nuclear imaging and radiotherapy: compositions and applications

供应商参考报价(招募中)

品牌试剂参考报价(招募中)

📌 第三方产品分析报告

✅ COA系统入驻 | 共享模式

主要参考文献


1: Dib J, Bosse C, Tsivou M, Glatt AM, Geisendorfer T, Geyer H, Gmeiner G, Sigmund G, Thevis M. Is heptaminol a (major) metabolite of octodrine? Drug Test Anal. 2019 Nov;11(11-12):1761-1763. doi: 10.1002/dta.2737. Epub 2019 Dec 11. application to spiked human plasma. Spectrochim Acta A Mol Biomol Spectrosc. 2020 Feb 15;227:117711. doi: 10.1016/j.saa.2019.117711. Epub 2019 Oct 25. 35(6):821-826. doi: 10.1002/bio.3787. Epub 2020 Jan 28. 33(6):1107-1112. doi: 10.1002/bio.3516. Epub 2018 Jul 3. 26(12):2167-71. German. 19(1):e8-17. doi: 10.1097/MJT.0b013e3181e9b630. 30(6):365-9. doi: 10.1093/jat/30.6.365. 24(162):184. 49(3):127-38. French. 68(7):791-9. French.

合成参考文献


摘要:Adriaensen, K.; De Vos, D., Science of Synthesis, (2022) , 167.
摘要:S72 | NTUPHTW | Pharmaceutically Active Substances from National Taiwan University | DOI:10.5281/zenodo.3955664
摘要:Sapelkin SV, Fedorov EE. [Ginkor Fort for management of lower limb chronic venous insufficiency]. Angiol Sosud Khir. 2004;10(2):69–73.
摘要:LOUBATIERES A, BOUYARD P. [Action of 6-amino-2-methyl-2-heptanol in the treatment of various experimental cardiovascular shock states]. J Physiol (Paris). 1954;46(1):441–3.
📝 需求与反馈
尽可能描述清楚需求与问题信息
×

通知