CAS: 256520-90-8; (R)-6-((S)-1-((1S,3R,8S,9S,10R,13S,14S,17R)-1-Hydroxy-10,13-Dimethyl-3-(((2R,3R,4S,5S,6R)-3,4,5-Trihydroxy-6-((((2R,3R,4S,5S,6R)-3,4,5-Trihydroxy-6-(Hydroxymethyl)Tetrahydro-2H-Pyran-2-yl)Oxy)Methyl)Tetrahydro-2H-Pyran-2-yl)Oxy)-2,3,4,7,8,9,10,11,12,13,14,15,16,17-Tetradecahydro-1H-Cyclopenta[a]Phenanthren-17-yl)Ethyl)-3,4-Dimethyl-5,6-Dihydro-2H-Pyran-2-One
该化合物是一种主要与Westania somnifera(Ashwagandha)隔离的生物活性血清内酯液态,它属于无核素类化合物,以其潜在的...
- 英文名称(R)-6-((S)-1-((1S,3R,8S,9S,10R,13S,14S,17R)-1-Hydroxy-10,13-Dimethyl-3-(((2R,3R,4S,5S,6R)-3,4,5-Trihydroxy-6-((((2R,3R,4S,5S,6R)-3,4,5-Trihydroxy-6-(Hydroxymethyl)Tetrahydro-2H-Pyran-2-yl)Oxy)Methyl)Tetrahydro-2H-Pyran-2-yl)Oxy)-2,3,4,7,8,9,10,11,12,13,14,15,16,17-Tetradecahydro-1H-Cyclopenta[a]Phenanthren-17-yl)Ethyl)-3,4-Dimethyl-5,6-Dihydro-2H-Pyran-2-One
- 中文名称(1α,3β,22R)-3-[(6-O-β-D-吡喃葡萄糖基-β-D-吡喃葡萄糖基)氧基]-1,22-二羟基麦角甾-5,24-二烯-26-酸δ-内酯
- IUPAC名称(R)-6-((S)-1-((1S,3R,8S,9S,10R,13S,14S,17R)-1-hydroxy-10,13-dimethyl-3-(((2R,3R,4S,5S,6R)-3,4,5-trihydroxy-6-((((2R,3R,4S,5S,6R)-3,4,5-trihydroxy-6-(hydroxymethyl)tetrahydro-2H-pyran-2-yl)oxy)methyl)tetrahydro-2H-pyran-2-yl)oxy)-2,3,4,7,8,9,10,11,12,13,14,15,16,17-tetradecahydro-1H-cyclopenta[a]phenanthren-17-yl)ethyl)-3,4-dimethyl-5,6-dihydro-2H-pyran-2-one
- 其它别名(1Alpha,3Beta,22R)-3-[(6-O-Beta-D-Glucopyranosyl-Beta-D-Glucopyranosyl)Oxy]-1,22-Dihydroxyergosta-5,24-Dien-26-Oic Acid Delta-Lactone; Withanoside V; Withanoside V(Sh); (1α,3β,22R)-3-[(6-O-β-D-Glucopyranosyl-β-D-Glucopyranosyl)Oxy]-1,22-Dihydroxy-Ergosta-5,24-Dien-26-Oic Acid δ-Lactone; Ergosta-5,24-Dien-26-Oic Acid, 3-[(6-O-β-D-Glucopyranosyl-β-D-Glucopyranosyl)Oxy]-1,22-Dihydroxy-, δ-Lactone, (1α,3β,22R)-; Diazoxide Impurity 6; Withanoside V-Rm
- CAS编号256520-90-8
- MFCD编号:MFCD09264638
- FDA UNII编号:EKV8XP7MQ6
- 分子式:C40H62O14分子量:766.92
- 产品CID: 1219288
- 产品分类生物化工 → 提取物 → 植物提取物
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2901220000-丙烯
2905122000-异丙醇
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主要参考文献
1. Jayaprakasam, B., Stasburg, G.A., and Nair, M.G. Potent lipid peroxidation inhibitors from Withania somnifera fruits. Tetrahedron 60(13), 3109-3121 (2004). 2. Dubey, S., Kallubai, M., and Subramanyam, R. Improving the inhibition of β-amyloid aggregation by withanolide and withanoside derivatives. Int. J. Biol. Macromol. 173, 56-65 (2021). 3. Kalra, R.S., Kumar, V., Dhanjal, J.K., et al. COVID19-inhibitory activity of withanolides involves targeting of the host cell surface receptor ACE2: Insights from computational and biochemical assays. J. Biomol. Struct. Dyn. 40(17), 7885-7895 (2021).合成参考文献
参考文献:10.1371/journal.pone.0200053
摘要:Dubey S, Kallubai M, Sarkar A, Subramanyam R. Elucidating the active interaction mechanism of phytochemicals withanolide and withanoside derivatives with human serum albumin. PLoS ONE. 2018 Nov 07;13(11):e0200053. doi: 10.1371/journal.pone.0200053.
参考文献:10.1016/j.ijbiomac.2021.01.094
摘要:Dubey S, Kallubai M, Subramanyam R. Improving the inhibition of β-amyloid aggregation by withanolide and withanoside derivatives. International Journal of Biological Macromolecules. 2021 Mar;173():56–65. doi: 10.1016/j.ijbiomac.2021.01.094.
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