CAS: 220465-43-0; (1H-Indol-4-yl)Boronic Acid
该化合物是一种多用途的boronic酸衍生物,广泛用于铃木-米亚乌拉交错反应,这是形成有机合成中碳-碳联结的关键方法,其单质骨架提供了宝贵的循环循环框架,有助于制药和农用化学研究.boronic酸功能组可高效地与丙烯或乙烯卤结合,便利复杂分子的合成.这种复合物在标准处理条件下具有良好稳定性,与一系列反应条件相容.其高纯度和再活性使得它成为在医药化学和材料科学应用中建造含有含持久性有机污染物的中间体的首选.
- 英文名称(1H-Indol-4-yl)Boronic Acid
- 中文名称4-吲哚硼酸
- IUPAC名称(1H-indol-4-yl)boronic acid
- 其它别名Indole-4-Boronic Acid; 1H-Indol-4-Ylboronic Acid; (1H-Indol-4-yl)Boronic Acid; 4-Boronoindole; 1H-Indole-4-Boronic Acid; 1H-Indol-4-Yl-4-Boronic Acid; Boronic Acid, 1H-Indol-4-Yl-; (1H)-Indol-4-Ylboronic Acid; 4-Indoleboronic Acid; 4-Indol
- CAS编号220465-43-0
- MFCD编号:MFCD03095175
- EINECS号:640-120-6
- 分子式:C8H8BNO2分子量:160.97
- 产品CID: 1143750
- 产品分类化学试剂 → 有机试剂 → 硼酸
物理性质
MSDS等安全信息
欧盟法规
C&L通报上下游产品
CAS号52488-36-5 4-溴吲哚 | CAS号121-43-7 硼酸三甲酯 | CAS号688-74-4 硼酸三丁酯 | CAS号942-24-5 3-吲哚甲酸甲酯 | CAS号101909-43-7 4-溴-1H-吲哚-3-羧酸甲酯 | CAS号653573-24-1 diethyl 3-(1H-i... | CAS号653573-29-6 ethyl 6-formyl-...合成工艺路线路线简述
📜4-溴-1H-吲哚-3-羧酸甲酯置于sodium Hydroxide,叔丁基锂,Potassium Hydride体系中,用 甲醇,乙醚,正己烷 用作溶剂,化学反应 1.83H,反应生成吲哚-4-硼酸
参考文献:麦角酸的新合成.
标题:麦角酸的新合成.
摘要:[反应:见正文](+/-)-麦角酸是通过经济的8步路线由4-溴吲哚和异辛烯酸合成的,不需要在合成过程中保护吲哚.首先在环化步骤中未能成功形成较简单的3-Acylindole衍生物,然后将其环化的初步努力.
Doi:10.1021/ol0354369
海关参考信息
- 2902200000-苯
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- 详情请参考：📖 海关编码查询和海关进出口税则
专利信息
专利号:US-2009227575-A1
优先权日:2008-03-04
标 题 :7H-PYRROLO[2,3-H]QUINAZOLINE COMPOUNDS, THEIR USE AS mTOR KINASE AND PI3 KINASE INHIBITORS, AND THEIR SYNTHESIS
发明人：VENKATESAN ARANAPAKAM MUDUMBAI; CHEN ZECHENG; DOS SANTOS OSVALDO; BROOIJMANS NATASJA; GOPALSAMY ARIAMALA
权利人:WYETH CORP
摘要:A 7H-pyrrolo[2,3-h]quinazoline compound of the formula I n n n n n n n n n n wherein Ar, R 1 , R 2 , R 7 , R 8 , R 9 , R 10 , R 11 , R 12 , and n are as defined in the specification, and methods for making same.
专利号:US-12428395-B2
优先权日:2019-08-01
标题 :Heterocyclic compounds as kinase inhibitor and uses thereof
发明人：PENDHARKAR DHANANJAY; RAMACHANDRAN SREEKANTH A; JADHAVAR PRADEEP S; PANPATIL DAYANAND; SAEED UZMA; KUMAR VIVEK; BIST DIPSHE
权利人:SPEROGENIX THERAPEUTICS LTD
摘要:The present disclosure relates generally to compounds useful in treatment of conditions associated with Checkpoint kinase (CHK), particularly CHK-1 enzymes. Specifically, the present invention discloses compound of formula (IA), which exhibits inhibitory activity against CHK-1 enzymes. Methods of treating conditions associated with excessive activity of CHK-1 enzymes with such compounds is disclosed. Uses thereof, pharmaceutical compositions, kits and method of synthesis also disclosed.
供应商参考报价(招募中)
品牌试剂参考报价(招募中)
📌 第三方产品分析报告
合成参考文献
合成方法参考DOI号:10.1021/jo981778u
📝 需求与反馈
尽可能描述清楚需求与问题信息
