CAS: 1620-30-0; Diphenyl(Pyridin-4-yl)Methanol

相似化合物

67853-63-8 3678-72-6 109810-81-3

上下游产品

4-lithiopyridine benzophenone pyridine-4-carboxylic acid isonicotinic acid ethylester4-(methoxydiphenylmethyl)pyridine 4-(hydroxy-diphenyl-methyl)-1-methyl-pyridinium iodide diphenyl-4-pyridylmethane 4-(diphenylmethyl)-1-methylpiperidine

📜二苯基-4-吡啶基甲烷置于potassium Tert-Butylate,二甲基亚砜体系中,化学反应 1.0H,以90%的收率获得二苯基(4-吡啶基)甲醇
参考文献:Transition-Metal Free Chemoselective Hydroxylation And Hydroxylation-deuteration Of Heterobenzylic Methylenes
标题:Transition-Metal Free Chemoselective Hydroxylation And Hydroxylation-deuteration Of Heterobenzylic Methylenes
摘要:We Developed An Approach For Direct Selective Hydroxylation Of Heterobenzylic Methylenes To Secondary Alcohols Avoiding Overoxidation To Ketones By Using A Kobu-T/dmso/air System. Most Reactions Could Reach Completion In Several Minutes To Give Hydroxylated Products In 41-76% Yields. Using Dmso-D6,This Protocol Resulted In Difunctionalization Of Heterobenzylic Methylenes To Afford α-Deuterated Secondary Alcohols (>93% Incorporation). By Employing This Method,Active Pharmaceutical Ingredients Carbinoxamine And Doxylamine Were Synthesized In Two Steps In Moderate Yields.
Doi:10.1021/acs.Orglett.0C03108