CAS: 14567-73-8; Dicalcium;Pentamagnesium;[dioxido-[oxo(Trioxidosilyloxy)Silyl]Oxysilyl]Oxy-[[dioxido-[oxo(Trioxidosilyloxy)Silyl]Oxysilyl]Oxy-Oxosilyl]Oxy-Dioxidosilane;Dihydroxide
- 英文名称Dicalcium;Pentamagnesium;[dioxido-[oxo(Trioxidosilyloxy)Silyl]Oxysilyl]Oxy-[[dioxido-[oxo(Trioxidosilyloxy)Silyl]Oxysilyl]Oxy-Oxosilyl]Oxy-Dioxidosilane;Dihydroxide
- 中文名称硅酸镁钙
- IUPAC名称dicalcium;pentamagnesium;[dioxido-[oxo(trioxidosilyloxy)silyl]oxysilyl]oxy-[[dioxido-[oxo(trioxidosilyloxy)silyl]oxysilyl]oxy-oxosilyl]oxy-dioxidosilane;dihydroxide
- 其它别名Tremolite (Ca2(Mg0.9-1Fe0-0.1)4.5-5Al0-0.5(Si7.5-8Al0-0.5)(OH)2O22); Tremolite asbestos.; tremolite; TREMOLITE-ACTINOLITE; tremolite, nonasbestiform; Asbestos, tremolite
- CAS编号14567-73-8
- EINECS号:604-486-0
- FDA UNII编号:QN851S6IRY
- 分子式:Ca2H2Mg5O24Si8分子量:809.559387
- 产品CID: 691350
物理性质
MSDS等安全信息
- GHS象形图
- GHS符号GHS08;
注释: Health hazard - 危险类别致癌性 类别1A
特定目标器官毒性-重复接触 类别1 - 警示词Danger(危险)
- 危险描述H350 |可能致癌.
H372 |长期或反复接触损害器官. - 防范说明P203, P260, P264, P270, P280, P318, P319, P405, and P501
- 安全声明IDENTIFICATION AND USE: Tremolite asbestos forms monoclinic crystals, long and thin columnar to fibrous. It can be gray-white, green, yellow, blue with silky luster. Tremolite is not at present exploited as asbestos mineral in its own right. Tremolite is an amphibole that is found as a contaminant in chrysotile and talc deposits. HUMAN STUDIES: In the 1960s and 1970s, well designed case-referent studies proved beyond doubt that exposure to airborne asbestos fibers was a cause of malignant mesothelioma. Some 35 cohort mortality studies in a large variety of industries during the 20-year period, 1974-1994, showed a wide range of outcomes, but in general the risk was higher in exposures which included amphiboles rather than chrysotile alone. Real progress began, however, with discoveries along several lines: the link between pleural changes and mineralogy, the concept and importance of biopersistence, the developments in counting and typing mineral fibers in lung tissue, and data on amphibole mining in South Africa and Australia for comparison with that on chrysotile in Canada and Italy. This led to the recognition of the potential contamination in North America of chrysotile with tremolite. A survey in Canada in 1980-1988 and other surveys demonstrated that crocidolite, amosite, and tremolite could explain almost all cases of mesothelioma. Effective confirmation of this was finally achieved with data on vermiculite miners in Libby, Montana, in the years 1983-1999, where exposure was to tremolite-actinolite and/or other amphibole fibers alone. The risk of lung cancer was increased up to sixfold in vermiculite miners exposed to tremolite and actinolite. In genotoxicity assay, an increase in the frequency of micronuclei in binucleated cells was observed, where crocidolite was most genotoxic, followed by tremolite, and amosite the least. ANIMAL STUDIES: Experimental animal studies comparing asbestos and non-asbestos varieties of tremolite indicate tremolite asbestos is markedly more carcinogenic. Oral administration of tremolite did not cause tumors in rats. Inhalation exposure to tremolite caused mesothelioma and lung cancer (carcinoma) in rats. In rats injected ip tremolite induced malignant mesothelioma with a high incidence (96% with 10 mg; 52% with 1 mg), and males were more susceptible than females. Tremolite induced dose-dependent S1 mutations in fiber-exposed cell. Tremolite was genotoxic in Drosophila melanogaster. In mice tremolite exposure caused increased cytokine production including IL-17, IL-6, TGF-beta, and TNF-a. | When asbestos fibers are inhaled, many are deposited on the epithelial surface of the respiratory tree. Fibers that are retained in the lung or mesothelium for long periods of time are capable of producing chronic inflammation and fibrotic and tumorigenic effects. These effects may be mediated by direct interactions between the fiber and key cellular macromolecules, or they may be mediated by the production of reactive oxygen species and other cellular factors originating from alveolar macrophages. In addition, the physical-chemical nature of the fiber appears to be an important determinant of toxicity. It is generally agreed that exposure to amphibole fibers can produce mesothelioma, and that the potency of amphibole fibers to produce mesothelioma is greater than that of chrysotile. Asbestos fibers can adsorb to a variety of cellular macromolecules (e.g., proteins,membrane lipids, RNA, DNA). The coulombic forces between the asbestos fiber and some of these macromolecules may induce conformational changes, and these changes could affect protein function and chromosomal fidelity. Fibers found to be translocated near the nucleus can interact with the cytoskeleton and interfere with chromosome segregation. (L222)
欧盟法规
ECHA物质C&L通报REACH预注册合成工艺路线路线简述
供应商参考报价(招募中)
品牌试剂参考报价(招募中)
📌 第三方产品分析报告
合成参考文献
摘要:Virta R; Asbestos. Kirk-Othmer Encyclopedia of Chemical Technology. (1999-2018). New York, NY: John Wiley & Sons. Online Posting Date: 15 Jul 2011
摘要:American Conference of Governmental Industrial Hygienists. Documentation of Threshold Limit Values for Chemical Substances and Physical Agents and Biological Exposure Indices for 2001. Cincinnati, OH. 2001., p. 2
摘要:29 CFR 1910.1001(g) (1) (USDOL); U.S. National Archives and Records Administration's Electronic Code of Federal Regulations. Available from, as of March 15, 2018:
摘要:29 CFR 1910.1001(f) (1) (i) (USDOL); U.S. National Archives and Records Administration's Electronic Code of Federal Regulations. Available from, as of March 14, 2018:
摘要:Full text: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4164883
📝 需求与反馈
尽可能描述清楚需求与问题信息
