CAS: 139713-81-8; (4Ar,5R,6R,7S,11R,12Ar)-7-(((2R,3S)-3-Hydroxy-2-Methylbutanoyl)Oxy)-9,12A,13,13-Tetramethyl-4-Methylene-1,2,3,4,4A,5,6,7,8,11,12,12A-Dodecahydro-6,10-Methanobenzo[10]Annulene-3,5,11-Triyl Triacetate

📜2α,5α,10β-Triacetoxy-14β-(2'-Methyl)-Butysyloxy-4(20),11-Taxadiene置于abisidia Coerulea Ifo 4011,Pda Medium体系中,用 乙醇 用作溶剂,化学反应 168.0H,以60 Mg的收率获得7β-Hydroxy-2α,5α,10β-Triacetoxy-14β-(2-Methylbutyryl)Oxytaxa-4(20),11-Diene
参考文献:Combined Biotransformations Of 4(20),11-Taxadienes
标题:Combined Biotransformations Of 4(20),11-Taxadienes
摘要:Taxuyunnanine C (1) And Its Analogs (2 And 3),The C-14 Oxygenated 4(20),11-Taxadienes From Callus Cultures Of Taxus Sp.,Were Regio-And Stereo-Selectively Hydroxylated At The 7 Beta Position By A Fungus,Abisidia Coerulea Ifo 4011,And It Was Interesting That The Longer The Alkyl Chain Of The Acyloxyl Group At C-14 Became,The Higher The Yield Of 7 Beta-Hydroxylated Product Was. Besides The Three 7 Beta-Hydroxylated Products (5,9,17). Other Nine New Products (7,11,12,14,15,16,18,20 And 21) And Six Known Products (4,6 8,10,13 And 19) Were Obtained. Subsequently. The Acetylated Derivatives (24 And 27) Of 7 Beta-And 9 Alpha-Hydroxylated Products Of I Were Regio-And Stereo-Specifically Hydroxylated At The 9 Alpha Position By Ginkgo Cells And 7 Position By A. Coerulea,Respectively. Thus,The Two Specific Oxidations Have Been Combined. These Bioconversions Would Provide Not Only Valuable Intermediates For The Semi-Synthesis Of Paclitaxel Or Other Bioactive Taxoids Front 1 And Its Analogs. But Also Some Useful Hints For The Biosynthetic Pathway Of Taxoid In The Natural Taxus Plant. (C) 2005 Elsevier Ltd. All Rights Reserved.
Doi:10.1016/j.Tet.2005.03.136

专利信息

专利号:CN-101781649-A
优先权日:2009-01-19
标 题:A method for efficiently inhibiting the synthesis of C-14 oxidized taxane by using microRNA

专利号:CN-101781649-B
优先权日:2009-01-19
标题:A method for efficiently inhibiting the synthesis of C-14 oxidized taxane by using microRNA