CAS: 136790-76-6; 7-((1R,2R,3R)-2-(4,4-Difluoro-3-Oxooctyl)-3-Hydroxy-5-Oxocyclopentyl)Heptanoic Acid

上下游产品

CAS号32233-40-2 科立内脂二醇 | CAS号1236109-25-3 [(3aR,4S,5R,6aS... | CAS号81190-06-9 [3Ar-(3aalpha,4... | CAS号333963-40-9 鲁比前列酮

Benzyl (Z)-7-[(1R,2R,3R)-2-((E)-4,4-Difluoro-3-Oxo-1-octenyl)-3-(Phenylmethoxy)-5-Oxocyclopentyl]-5-Heptenoate置于palladium 10% On Activated Carbon 氢气体系中,用 乙酸乙酯 用作溶剂,化学反应 10.0H,以70%的收率获得鲁比前列素
参考文献: Methods Of Making Lubiprostone And Intermediates Thereof[fr] Méthodes De Fabrication De Lubiprostone Et De Ses Intermédiaires
标题: Methods Of Making Lubiprostone And Intermediates Thereof[fr] Méthodes De Fabrication De Lubiprostone Et De Ses Intermédiaires
摘要:提供了制备lubiprostone及其中间体的过程.还提供了化合物,包括用于制备lubiprostone的中间体,以及包含lubiprostone和其他化合物的组合物,包括用于制备lubiprostone和其他化合物的中间体.(I)

专利信息

专利号:US-8513441-B2
优先权日:2008-08-29
标题:Prostaglandin synthesis and intermediates for use therein
发明人：ALBERICO DINO; CLAYTON JOSHUA; GORIN BORIS IVANOVICH; OUDENES JAN
权利人:ALBERICO DINO; CLAYTON JOSHUA; GORIN BORIS IVANOVICH; OUDENES JAN; ALPHORA RES INC
摘要:Fused cyclopentane-4-substituted 3,5-dioxalane lactone compounds useful as an intermediate in the synthesis of prostaglandin analogs are provided. The compounds have the formula A: n nwherein R represents an aryl group such as p-methoxyphenyl.n n This compound can be reacted with a lower alkyl aluminum compound to open the dioxalane ring and reduce the lactone to lactol, without over-reducing to diol. The resulting compound can be functionalized to insert chemical side groups of target prostaglandins, adding the required α-side chain and then the required ω-side chain sequentially and independently of each other. The compounds and process are particularly suitable for preparing lubiprostone.