CAS: 131801-69-9; 2-(1-Hydroxycyclohexyl)-2-(4-Methoxyphenyl)Acetonitrile

英文名称2-(1-Hydroxycyclohexyl)-2-(4-Methoxyphenyl)Acetonitrile
中文名称1-(羟基环己基)-(4-甲氧基苯基)乙腈
其它别名Benzeneacetonitrile,a-(1-hydroxycyclohexyl)-4-methoxy-,(?à)-; (4-Methoxyphenyl)-(1-hydroxycyclohex-1-yl)acetonitrile; 1-[Cyano(4-methoxyphenyl)methyl]cyclohexanol; 1-[Cyano(p-methoxyphenyl)methyl]cyclohexanol; a-(p-Methoxyphenyl)-a-(1-hydroxycyclohexyl)acetonitrile
CAS编号131801-69-9
MFCD编号:MFCD06658142
FDA UNII编号:KMK8U27KDY
分子式:C15H20NO2分子量:246.32
产品CID: 484790

相似结构搜索
InChIKey: ASYJSBPNAIDUHX-UHFFFAOYSA-N
1S/C15H19NO2/c1-18-13-7-5-12(6-8-13)14(11-16)15(17)9-3-2-4-10-15/h5-8,14,17H,2-4,9-10H2,1H3
计算化学: 氢键受体数3.0氢键供体数1.0可旋转键数3.0

MSDS等安全信息

上下游产品

cyclohexanone p-methoxybenzylnitrile cyclohexanol 4-methoxybenzonitrile N-[2-(1-hydroxycyclohexyl)-2-(4-methoxyphenyl)ethyl]formamide N-Desmethylvenlafaxine hydr°Chloride N,N-Didesmethyldesvenlafaxine

合成工艺路线路线简述

海关参考信息

2902600000-乙苯
2902700000-异丙基苯
2905122000-异丙醇
2905143000-叔丁醇
💡 提示：海关信息按照顺序优先匹配，如需确认的海关信息，请参考相关资料。
详情请参考：📖 海关编码查询和海关进出口税则

专利信息

专利号:US-9527800-B2
优先权日:2013-10-29
标题:Process for total synthesis of venlafaxine
发明人：CHAVAN SUBHASH PRATAPRAO; PAWAR KAILASH PRALHAD
权利人:COUNCIL SCIENT IND RES
摘要:There is a need for short, resolution free asymmetric process for synthesis of one isomer of venlafaxine, (âˆ’)-venlafaxine. The invention provides a novel, short process of synthesis of (âˆ’)-venlafaxine, with yield greater than 50% and ee>99%. This process can be used for racemic synthesis of venlafaxine with overall yield 65%.

专利号:US-7605290-B2
优先权日:2006-07-26
标题 :Processes for the synthesis of O-desmethylvenlafaxine
发明人：NIDDAM-HILDESHEIM VALERIE; SHENKAR NATALIA; SHACHAN-TOV SHARONA
权利人:TEVA PHARMA
摘要:The present invention describes processes for the preparation of O-desmethylvenlafaxine and tridesmethylvenlafaxine, which may be used as an intermediate in preparing O-desmethylvenlafaxine.

专利号:US-2009069601-A1
优先权日:2006-07-26
标题:Processes for the synthesis of O-desmethylvenlafaxine
发明人：NIDDAM-HILDESHEIM VALERIE; NIDAM TAMAR; DOLITZKY BEN-ZION
权利人:NIDDAM-HILDESHEIM VALERIE; NIDAM TAMAR; DOLITZKY BEN-ZION
摘要:The present invention describes processes for the preparation of O-desmethylvenlafaxine and tridesmethylvenlafaxine, which may be used as an intermediate in preparing O-desmethylvenlafaxine.

专利号:US-2008221356-A1
优先权日:2006-07-26
标题:Processes for the synthesis of O-desmethylvenlafaxine
发明人：NIDDAM-HILDESHEIM VALERIE; NIDAM TAMAR; DOLITZKY BEN-ZION
权利人:NIDDAM-HILDESHEIM VALERIE; NIDAM TAMAR; DOLITZKY BEN-ZION
摘要:The present invention describes processes for the preparation of O-desmethylvenlafaxine and tridesmethylvenlafaxine, which may be used as an intermediate in preparing O-desmethylvenlafaxine.

专利号:US-2009137846-A1
优先权日:2006-07-26
标题 :Processes for the synthesis of O-Desmethylvenlafaxine
发明人：NIDDAM-HILDESHEIM VALERIE; NIDAM TAMAR; DOLITZKY BEN-ZION; FRENKEL GUSTAVO
权利人:NIDDAM-HILDESHEIM VALERIE; NIDAM TAMAR; DOLITZKY BEN-ZION; FRENKEL GUSTAVO
摘要:The present invention describes processes for the preparation of O-desmethylvenlafaxine and tridesmethylvenlafaxine, which may be used as an intermediate in preparing O-desmethylvenlafaxine.

专利号:WO-2008059525-A3
优先权日:2006-09-29
标题:An improved process for the preparation of venlafaxine and its analogs
发明人：LAL BANSI; GUND VITTHAL GENBHAU
权利人:CALYX CHEMICALS AND PHARMACEUT; LAL BANSI; GUND VITTHAL GENBHAU
摘要:A novel single step process for the synthesis of venlafaxine of formula I and N-desmethylvenlafaxine of formula II from 2-(1-hydroxycyclohexyl)-2-(4-methoxyphenyl)acetonitrile [cyano-intermediate] of formula V V comprising reacting 2-(1-hydroxycyclohexyl)-2-(4-methoxyphenyl)acetonitrile with an alkylamine and/or its salt in a solvent in the presence of a transition metal catalyst, under hydrogen atmosphere.