CAS: 103285-22-9; 1-((2R,3R,4R,5R)-5-((Bis(4-Methoxyphenyl)(Phenyl)Methoxy)Methyl)-4-Hydroxy-3-Methoxytetrahydrofuran-2-yl)Pyrimidine-2,4(1H,3H)-Dione

上下游产品

diazomethane 5'-dimethoxytrityluridine 4,4'-dimethoxytrityl chloride 2'-O-methyluridine

2,2'-脱水尿苷置于吡啶体系中,用 N,N-二甲基甲酰胺 用作溶剂,化学反应 6.0H,反应生成1-((2R,3R,4R,5R)-5-((双(4-甲氧基苯基)(苯基)甲氧基)甲基)-4-羟基-3-甲氧基四氢呋喃-2-基)嘧啶-2,4(1H,3H)-二酮
参考文献:使用可转换的核苷和dna催化的rna连接合成自旋标记的核糖开关rna.
标题:使用可转换的核苷和dna催化的rna连接合成自旋标记的核糖开关rna.
摘要:可以通过电子顺磁共振(epr)光谱监测的化学稳定的氮氧自由基可以提供有关功能rna(如核糖开关)的结构和动态特性的信息.可转换核苷方法用于在环外n 4-氨基处安装2,2,6,6-四甲基哌啶-1-氧基(tempo)和2,2,5,5-四甲基吡咯烷-1-氧基(脯氨酰基)标签rna中胞苷和2'-O-甲基胞嘧啶核苷酸的序列 为了获得超出固相合成极限的位点特异性标记的长核糖开关rna,我们报道了使用体外选择的脱氧核酶作为催化剂的自旋标记rna的连接,并证明了tempo标记的53 Nt Sam-Iii和118 Nt Sam-1核糖开关结构域(sam = S-腺苷甲硫氨酸).
Doi:10.1016/j.Bmc.2013.04.007

专利信息

专利号:US-5936080-A
优先权日:1996-05-24
标题 :Compositions and methods for the synthesis of organophosphorus derivatives
发明人：STEC WOJCIECH J; WOZNIAK LUCYNA
权利人:GENTA INC; POLSKA AKADEMIA NAUK INSTYTUT
摘要:New organophosphorus mononucleoside derivatives, methods of their synthesis and methods for the synthesis of organophosphorus dinucleotide derivatives utilizing the organophosphorus mononucleosides are provided. Synthesized organophosphorus mononucleoside derivatives of the present invention are characterized by the formula; ##STR1## Organophosphorus dinucleoside derivatives prepared from the synthesis methods provided in the present invention are characterized by the formula; ##STR2##

专利号:US-5856465-A
优先权日:1996-05-24
标 题:Compositions and methods for the synthesis of chirally pure organophosphorus nucleoside derivatives
发明人：STEC WOJCIECH JACEK; WOZNIAK LUCYNA
权利人:POLSKA AKAD NAUK CENTRUM
摘要:Methods for the stereospecific synthesis of chirally pure organophosphorus dinucleotide derivatives and nucleoside monomer synthons used in their synthesis are provided. These methods allow for conversion of nucleoside intermediates of unchosen sense of P-chirality to nucleoside monomer synthons of chosen sense of P-chirality. Also provided are novel nucleoside intermediates useful in such methods.

专利号:EP-0850248-B1
优先权日:1995-09-01
标 题 :Compositions and methods for the synthesis of organophosphorus derivatives
发明人：STEC WOJCIECH J; WOZNIAK LUCYNA
权利人:POLSKA AKAD NAUK CENTRUM
摘要:Methods for the stereospecific synthesis of chirally pure organophosphorus dinucleotide derivatives and nucleoside monomer synthons used in their synthesis are provided. These methods allow for conversion of nucleoside intermediates of unchosen sense of P-chirality to nucleoside monomer synthons of chosen sense of P-chirality. Also provided are novel nucleoside intermediates useful in such methods.

专利号:EP-0828749-B1
优先权日:1995-05-26
标题 :Methods for the synthesis of organophosphorus derivatives
发明人：STEC WOJCIECH J; WOZNIAK LUCYNA; RILEY TIMOTHY
权利人:GENTA INC; POLSKA AKADEMIA NAUK INSTYTUT
摘要:New organophosphorus mononucleoside derivatives, method of their synthesis and methods for the synthesis of organophosphorus dinucleotide derivatives utilizing the organophosphorus mononucleoside derivatives are provided. Synthesized organophosphorus mononucleoside derivatives of the present invention are characterized by formula (1).

专利号:US-5013830-A
优先权日:1986-09-08
标题 :Compounds for the cleavage at a specific position of RNA, oligomers employed for the formation of said compounds, and starting materials for the synthesis of said oligomers
发明人：OHTSUKA EIKO; INOUE HIDEO; MORISAWA HIROKAZU; SHIBAHARA SUSUMU; MUKAI SACHIKO; NISHIHARA TOHRU
权利人:AJINOMOTO KK
摘要:There is disclosed a compound having a double chain which is composed of an RNA (+chain) and a complementary DNA (-chain), wherein a portion of the DNA (-chain) has been replaced by an RNA or a derivative thereof, and wherein, when the compound is subjected to the action of an enzyme having a ribonuclease H activity, it is possible to preferentially cleave the RNA (+chain) in a position corresponding to the unsubstituted portion of the DNA (-chain). The compound can thus be used for the preferential cleavage of a phosphodiester bond in a specific position of RNA. Accordingly, the invention provides a useful means for preparing, for instance, a deletion mutant. There is also disclosed a mixed oligomer which comprises an oligomer of RNA or a derivative thereof and a DNA oligomer, wherein the RNA oligomer or a derivative thereof is conjugated to the DNA oligomer via a phosphate diester linkage between the 5'-hydroxyl group and the 3'-hydroxyl group in the ribose or deoxyribose moiety. There is further disclosed a nucleoside derivative of a given general formula for use as a starting material.

专利号:US-11566042-B2
优先权日:2014-11-18
标 题 :Phosphoramidite synthones for the synthesis of self-neutralizing oligonucleotide compounds
发明人：TABATADZE DAVID R; YANACHKOV IVAN B
权利人:ZATA PHARMACEUTICALS INC
摘要:Compositions and compounds of nucleoside phosphoramidites and modified oligonucleotides, each comprising one or more charge-neutralizing moieties according to the formula VThe nucleoside phosphoramidites permit facile attachment of the neutralizing moieties on the backbones of the modified oligonucleotides. The modified oligonucleotides can be used as therapeutic agents (i.e., oligotherapeutics) for the treatment of cancer, autoimmune disorders, genetic diseases, infectious diseases, neurological diseases, inflammatory diseases, metabolic diseases and others.