CAS: 103129-58-4; Benazepril Ethyl Ester
该化合物是一种中间化合物,主要用于合成乙酰丙酰丙烯(ACE)抑制酶,作为乙基乙酯衍生物,它提供了更大的稳定性和溶性,促进了制药生产过程中的高效加工,其高纯度和定义明确的化学结构确保了合成途径的一贯性,使其成为生产抗血压药物的可靠前体.该化合物与标准反应条件的兼容性及其在优化产量方面的作用进一步突出了其在工业规模的......
- 英文名称Benazepril Ethyl Ester
- 中文名称贝那普利乙酯
- IUPAC名称(S)-Ethyl 2-(((S)-1-(2-ethoxy-2-oxoethyl)-2-oxo-2,3,4,5-tetrahydro-1H-benzo[b]azepin-3-yl)amino)-4-phenylbutanoate
- 其它别名Benazepril Ep Imp G; Benazepril Imp G (Ep): Ethyl (2S)-2-[[(3S)-1-(2-Ethoxy-2-Oxoethyl)-2-Oxo-2,3,4,5-Tetrahydro-1H-1-Benzazepin-3-Yl]Amino]-4-Phenylbutanoate; Benazepril Related Compound G (15 Mg) ((3-(1 -Ethoxycarbonyl-3-Phenyl-(1 S)-Propyl)Amino-2,3,4,5-Tetrahydro-2-Oxo-1H-1-(3S)-Benzaze-Pine)-1-Acetic Acid, Ethyl Ester); Benazepril Related Compound G (15 Mg) ((3-(1-Ethoxycarbonyl-3-Phenyl-(1S)-Propyl)Amino-2,3,4,5-Tetrahydro-2-Oxo-1H-1-(3S)-Benzazepine)-1-Acetic Acid,Ethyl Ester); Benazepril Ethy Ester; Benazepril Ethyl Ester; [s-(R*,R*)]-3-[[1-(Ethoxycarbonyl)-3-Phenylpropyl]Amino]-2,3,4,5-Tetrahydro-2-Oxo-1H-1-Benzazepine-1-Acetic Acid Ethyl Ester; Benazepril Related Compound G (15 Mg) (Cold Shipment Required) ((3-(1-Ethoxycarbonyl-3-Phenyl-(1S)-Propyl)Amino-2,3,4,5-Tetrahydro-2-Oxo-1H-1-(3S)-Benzazepine)-1-Acetic Acid, Ethyl Ester)
- CAS编号103129-58-4
- MFCD编号:MFCD28900273
- EINECS号:111-002-7
- FDA UNII编号:K53IWT5YZ1
- 分子式:C26H32N2O5分子量:452.55
- 产品CID: 64756
- 产品分类有机原料→分子砌块→芳杂环类化合物→其它芳杂环类化合物
相似化合物
215447-89-5 86541-77-7 98626-50-7物理性质
MSDS等安全信息
欧盟法规
C&L通报上下游产品
CAS号82586-61-6 ethyl 2-bromo-4... | CAS号86499-52-7 (S)-3-Amino-2,3... | CAS号86541-75-5 贝那普利合成工艺路线路线简述
📜2-溴-4-苯基丁酸乙酯,(S)-3-氨基-2,3,4,5-四氢-2-氧代-1H-1-苯并氮杂卓-1-乙酸乙酯置于三乙胺体系中,用 N-甲基乙酰胺,乙酸乙酯 用作溶剂,化学反应生成贝那普利相关化合物 G
参考文献:3-Amino-(1)-Benzazepin-2-One-1-Alkanoic Acids
标题:3-Amino-(1)-Benzazepin-2-One-1-Alkanoic Acids
摘要:各种取代的1-羧甲基-3-(羧甲基氨基)-2,3,4,5-四氢-1H-[1]苯并氮杂卓-2-酮及其功能衍生物是血管紧张素转化酶抑制剂,可用作抗高血压药.包括这些化合物的合成,组合物及治疗方法.
专利信息
专利号:US-4410520-A
优先权日:1981-11-09
标题 :3-Amino-[1]-benzazepin-2-one-1-alkanoic acids
发明人：WATTHEY JEFFREY W H
权利人:CIBA GEIGY CORP
摘要:Variously substituted 1-carboxymethyl-3-(carboxymethylamino)-2,3,4,5-tetrahydro-1H-[1]benzaz epin-2-ones and functional derivatives are angiotension converting enzyme inhibitors and are useful as antihypertensive agents. Synthesis of, compositions and methods of treatment utilizing such compounds are included.
专利号:US-4575503-A
优先权日:1983-02-10
标 题:3-Amino-[1]-benzazepin-2-one-1-alkanoic acids
发明人：WATTHEY JEFFREY W H
权利人:CIBA GEIGY CORP
摘要:Variously substituted 1-carboxymethyl-3-(carboxymethylamino)-2,3,4,5-tetrahydro-1H-[1]benzaz epin-2-ones and functional derivatives are angiotensin converting enzyme inhibitors and are useful as antihypertensive agents. Synthesis of, compositions and methods of treatment utilizing such compounds are included.
专利号:US-4473575-A
优先权日:1982-07-19
标 题 :3-Amino-(1)-benzazepin-2-one-1-alkanoic acids
发明人：WATTHEY JEFFREY W H
权利人:CIBA GEIGY CORP
摘要:Variously substituted 1-carboxymethyl-3-(carboxymethylamino)-2,3,4,5-tetrahydro-1H-[1]benzaz epin-2-ones and functional derivatives are angiotensin converting enzyme inhibitors and are useful as antihypertensive agents. Synthesis of, compositions and methods of treatment utilizing such compounds are included.
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📌 第三方产品分析报告
主要参考文献
参考标题:3-Amino-[1]-Benzazepin-2-One-1-Alkanoic Acids摘要:Variously Substituted 1-Carboxymethyl-3-(Carboxymethylamino)-2,3,4,5-Tetrahydro-1H-[1]Benzazepin -2-Ones And Functional Derivatives Are Angiotensin Converting Enzyme Inhibitors And Are Useful As Antihypertensive Agents. Synthesis Of, Compositions And Methods Of Treatment Utilizing Such Compounds Are Included.
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