CAS: 96202-57-2; 5-Fluoro-6-Chloroisatin

该化合物是一种卤化异物衍生物,可能用于制药和农用化学研究,其结构包括氯和氟分成分,加强了合成途径的活性性和选择性.2-3位置的二氯酮为进一步功能化提供了多功能性,使它成为热循环化学的一个宝贵中间体.该化合物在标准条件下的稳定确保了实验环境中的一贯性.其独特的替代模式可能促进生物活性,特别是在酶抑制剂或生物活性分子的开发方面.研究人员认为该化合物具有明确的纯度和与一系列有机变异的兼容性.

英文名称5-Fluoro-6-Chloroisatin
中文名称6-氯-5-氟靛红
IUPAC名称6-chloro-5-fluoroindoline-2,3-dione
其它别名5-氟-6-氯靛红; 6-Chloro-5-Fluoroisatin
CAS编号96202-57-2
MFCD编号:MFCD05664872
分子式:C8H3ClFNO2
分子量:199.57
产品CID: 2016626
产品分类有机原料→分子砌块→芳杂环类化合物→吲哚啉类化合物

相似结构搜索
InChIKey: GHBWNCFDSGAFIT-UHFFFAOYSA-N
InChI=1S/C8H3ClFNO2/c9-4-2-6-3(1-5(4)10)7(12)8(13)11-6/h1-2H,(H,11,12,13)…
计算化学: 氢键受体数2.0氢键供体数1可旋转键数0

MSDS等安全信息

GHS符号GHS07
警示词Warning
危险描述H315-H319
防范说明P264-P280-P302+P352-P362+P364

上下游产品

CAS号367-21-5 3-氯-4-氟苯胺 | CAS号302-17-0 水合氯醛 | CAS号122509-72-2 6-氯-5-氟吲哚

合成工艺路线路线简述

108288-15-9 = 96202-57-2
反应条件:1.1 Reagents: Sulfuric Acid Solvents: Water; 65 °C; 1.5 H,90 °C; 90 °C -> Rt1.2 Reagents: Water; 10 Min,Cooled
标题:4-Quinolinecarboxamide Derivatives As Trpv4 Antagonists And Their Preparation And Use For The Treatment Of Diseases
参考文献:World Intellectual Property Organization]

302-17-0 + 367-21-5 = 96202-57-2
反应条件:1.1 Reagents: Sodium Sulfate Solvents: Water; Rt -> 35 °C1.2 Solvents: Water; Heated1.3 Reagents: Hydroxyamine Hydrochloride,Hydrochloric Acid Solvents: Water; 2 H,80 - 90 °C; 90 °C -> 50 °C1.4 Reagents: Sulfuric Acid Solvents: Water; 30 Min,< 65 °C; 15 Min,65 °C -> 80 °C; 80 °C -> 70 °C1.5 Reagents: Water; 1 H,Cooled1.6 Reagents: Sodium Hydroxide Solvents: Water; 60 °C1.7 Reagents: Acetic Acid; Acidified; 0.5 H,60 °C; 60 °C -> 35 °C
标题:4-Quinolinecarboxamide Derivatives As Trpv4 Antagonists And Their Preparation And Use For The Treatment Of Diseases
参考文献:World Intellectual Property Organization]

108288-15-9 = 96202-57-2
反应条件:1.1 Reagents: Sulfuric Acid; 20 Min,50 °C; 50 °C -> 65 °C; 1 H,65 °C
标题:Synthesis Of Substituted Tryptanthrin Via Aryl Halides And Amines As Antitumor And Anti-Mrsa Agents
作者:Zheng,Xudong; Hou,Baolong; Wang,Rui; Wang,Yinyin; Wang,Cuiling; Et Al
参考文献:Tetrahedron 日期:2019 卷标:75(48)]

108288-15-9 = 96202-57-2
反应条件:1.1 Catalysts: Sulfuric Acid; 60 - 70 °C; 70 °C -> 80 °C; 10 Min,80 °C
标题:Synthesis And Evaluation Of New Bis-Isatin Derivatives For Antioxidant Activity
作者:Karthik,K.; Blessi Priyanka,K.; Manjula,S.; Sammaiah,G.
参考文献:International Journal Of Pharmacy And Pharmaceutical Sciences 日期:2013 卷标:5(4) 页码:224-227]

108288-15-9 = 96202-57-2 + 84378-94-9
反应条件:1.1 Reagents: Sulfuric Acid
标题:Synthesis Of Aminoquinolone Derivatives
作者:Krishnan,Raghavan; Lang,S. A. Jr.; Siegel,Marshall M.
参考文献:Journal Of Heterocyclic Chemistry 日期:1986 卷标:23(6) 页码:1801-4]

108288-15-9 = 96202-57-2
反应条件:1.1 Reagents: Sulfuric Acid; 60 - 70 °C; Cooled; Rt -> 80 °C; 10 Min,80 °C
标题:Novel 2-Amino-N'-(2-Oxoindolin-3-Ylidene)Benzo[d]Oxazol-5-Carbohydrazides As Anti-Inflammatory Agents
作者:Lavanya,A.; Parlapalli,Arunadevi; Ciddi,Manasa; Sarangapani,M.
参考文献:International Journal Of Pharmaceutical Sciences And Research 日期:2015 卷标:6(1) 页码:212-218]

108288-15-9 = 96202-57-2
反应条件:1.1 Reagents: Sulfuric Acid
标题:Synthesis And Evaluation Of New Bis-Isatin Derivatives For Cytotoxic Activity
作者:Karthik,K.; Priyanka,K. Blessi; Manasa,C.; Sammaiah,G.
参考文献:World Journal Of Pharmaceutical Research 日期:2014 卷标:3(2) 页码:2429-2433]

302-17-0 + 367-21-5 = 96202-57-2
反应条件:1.1 Reagents: Hydroxyamine Hydrochloride,Hydrochloric Acid,Sodium Sulfate Solvents: Water; Reflux1.2 Reagents: Sulfuric Acid Solvents: Water; 80 °C
标题:Synthesis And Biophysical Evaluation Of Arylhydrazono-1H-2-Indolinones As β-Amyloid Aggregation Inhibitors
作者:Campagna,Francesco; Catto,Marco; Purgatorio,Rosa; Altomare,Cosimo D.; Carotti,Angelo; Et Al
参考文献:European Journal Of Medicinal Chemistry 日期:2010 卷标:46(1) 页码:275-284]

1888389-23-8 = 96202-57-2 + 84378-94-9
反应条件:1.1 Reagents: Sulfuric Acid Solvents: Water; 60 °C; 30 Min,80 °C; 80 °C -> Rt1.2 Reagents: Water; Rt; 10 Min,Rt
标题:Utilizing Solubility Differences To Achieve Regiocontrol In The Synthesis Of Substituted Quinoline-4-Carboxylic Acids
作者:Lindsay-Scott,Peter J.; Barlow,Helen
参考文献:Synlett 日期:2016 卷标:27(10) 页码:1516-1520]

302-17-0 + 367-21-5 = 96202-57-2 + 84378-94-9
反应条件:1.1 Reagents: Hydroxyamine Hydrochloride,Hydrochloric Acid Solvents: Water2.1 Reagents: Sulfuric Acid
标题:Synthesis Of Aminoquinolone Derivatives
作者:Krishnan,Raghavan; Et Al
参考文献:Journal Of Heterocyclic Chemistry 日期:1986 卷标:23(6) 页码:1801-4]

367-21-5 = 96202-57-2 + 84378-94-9
反应条件:1.1 Reagents: Hydroxyamine Hydrochloride,Hydrochloric Acid,Sodium Sulfate Solvents: Water; Rt; 1 H,90 °C2.1 Reagents: Sulfuric Acid Solvents: Water; 60 °C; 30 Min,80 °C; 80 °C -> Rt2.2 Reagents: Water; Rt; 10 Min,Rt
标题:Utilizing Solubility Differences To Achieve Regiocontrol In The Synthesis Of Substituted Quinoline-4-Carboxylic Acids
作者:Lindsay-Scott,Peter J.; Et Al
参考文献:Synlett 日期:2016 卷标:27(10) 页码:1516-1520

3-氯-4-氟苯胺置于盐酸,硫酸,盐酸羟胺,Sodium Sulfate体系中,用水作为反应溶剂,化学反应 2.25H,反应生成 6-氯-5-氟靛红
参考文献:与细胞外结构域结合的表皮生长因子受体 (Egfr) 小分子抑制剂的初步发现.
标题:与细胞外结构域结合的表皮生长因子受体 (Egfr) 小分子抑制剂的初步发现.
摘要:表皮生长因子受体 (Egfr) 是一种跨膜糖蛋白,属于蛋白激酶超家族.它由一个胞外结构域,一个跨膜锚定区和一个具有酪氨酸激酶活性的胞质区组成.egfr 激酶的基因突变导致更高的活性,从而刺激下游信号通路,进而影响转录和细胞周期进程.由于突变 Egfr 参与肿瘤和炎症性疾病,在过去的十年中,已经广泛研究了几种 Egfr 抑制策略,或者靶向细胞外结构域(通过单克隆抗体)或细胞内激酶结构域(通过 Atp 模拟小分子) . 单克隆抗体会损害与生长因子的结合,受体二聚化及其激活,而小分子阻断细胞内催化活性.在这里,我们描述了一种新型小分子的开发,称为 Dsf-102,它与 Egfr 的细胞外结构域相互作用.当在 Kras 突变体 A549 细胞中进行体外测试时,它通过发挥 (I) 剂量依赖性毒性作用削弱 Egfr 活性;(II) Erk,Mapk P38 和 Akt 的负调控;(Iii) 调节 Egfr
DOI:10.3390/cancers14153647