CAS: 888711-44-2; Potassium (Bromomethyl)Trifluoroborate

相似化合物

13862-28-7 1643845-63-9

二溴甲烷置于正丁基锂,硼酸三异丙酯,甲烷磺酸,Potassium Hydrogen Bifluoride体系中,用 四氢呋喃,正己烷 作为反应溶剂,化学反应 0.5H,以82%的收率获得产物(溴甲基)三氟硼酸钾
参考文献:烷氧基甲基三氟硼酸钾的制备及其与芳基氯的交叉偶联.
标题:烷氧基甲基三氟硼酸钾的制备及其与芳基氯的交叉偶联.
摘要:通过用各种醇盐对溴甲基三氟硼酸钾进行 Sn2 置换,以优异的产率制备了多种烷氧基甲基三氟硼酸盐底物.这些烷氧基甲基三氟硼酸盐与几种芳基氯有效地交叉偶联.这种方法提供了一种独特的不协调断开,允许在设计新的和改进的合成途径时具有更大的灵活性.
DOI:10.1021/ol800532P

专利信息

专利号:US-9518067-B2
优先权日:2013-03-27
标题 :Trifluoroborate mass spectrometric tags
发明人：HUANG YUMEI
权利人:CELLMOSAIC INC
摘要:The invention provides compositions and methods for mass spectrometric (MS), organic synthesis, and applications of organo-trifluoroborate, for example, as mass tags for use in negative ion mode. When subject to MS fragmentation, organo-trifluoroborates preferentially undergo neutral losses of hydrogen fluoride (HF) or boron trifluoride (BF 3 ) molecules, transferring the negative charge to the rest of the molecule. Such a fragmentation pattern is used to detect and quantitate analytes of interest after derivatization with organo-trifluoroborates.