CAS: 611-33-6; 8-Chloroquinoline

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2-氯-N-(2-丙炔-1-基)苯胺置于silver Hexafluoroantimonate体系中,化学反应 0.08H,反应生成 8-氯喹啉
参考文献:微波辅助条件下由芳族硼酸,氨水和炔丙基溴一锅法合成n-芳基炔丙基胺
标题:微波辅助条件下由芳族硼酸,氨水和炔丙基溴一锅法合成n-芳基炔丙基胺
摘要:摘要在微波辅助条件下,由芳族硼酸,氨水和炔丙基溴容易地一锅合成n-芳基炔丙基胺.该反应可通过两步程序在总共10分钟内顺利完成,包括铜催化的芳香族硼酸与氨水的偶联以及随后的炔丙基溴的炔丙基化反应.
DOI:10.1016/j.Cclet.2014.03.011

专利信息

专利号:US-3943142-A
优先权日:1969-01-24
标 题:Dye intermediates and their preparation and use in the synthesis of methine dyes
发明人：OWEN JOHN R
权利人:EASTMAN KODAK CO
摘要:Compositions of matter are provided comprising a stable, non-vaporous monomeric methylene base selected from a 2-methylenethiazoline; a 2-methylenebenzothiazoline; a 2-methylenenaphthothiazoline; a 2-methylenebenzoselenazoline; and a 2-methylenenaphthoselenazoline. The compositions of the invention are prepared by reacting the parent 2-methyl quaternary salt with a non-hydroxylic base which removes a proton of the heterocyclic salt together with a proton acceptor which inhibits build-up of the hydro salt of the non-hydroxylic base, the reaction being conducted under anhydrous conditions in a non-hydroxylic liquid in which the heterocyclic quaternary salt is sufficiently insoluble to inhibit dimer formation. The compositions of the invention are employed in the preparation of methine dyes.

专利号:CN-113717098-A
优先权日:2021-09-08
标题 :A method for the synthesis of tetrahydroquinoline compounds with non-hydrogen participation in selective catalytic hydrogenation of quinoline compounds

专利号:WO-2024068976-A1
优先权日:2022-09-29
标 题 :Azole derivatives as shp2 inhibitors
发明人：PETROCCHI ALESSIA; MONTALBETTI CHRISTIAN; DI FABIO ROMANO; CIAMMAICHELLA ALINA; ROSSETTI ILARIA
权利人:IRBM S P A; C N C C S S C A R L COLLEZIONE NAZ DEI COMPOSTI CHIMICI E CENTRO SCREENING
摘要:The present invention relates to new compounds capable of inhibiting the activity of SHP2 phosphatase. Compounds of the invention can be used for the treatment of disorders associated with SHP2 deregulation. The present invention also relates to pharmaceutical compositions containing said compounds and to their method of synthesis.

专利号:EP-1465880-B1
优先权日:2001-11-28
标题 :5-sulphanyl-4h-1,2,4-triazole derivatives and their use to treat disorders associated with somatostatine
发明人：GALCERA CONTOUR MARIE-ODILE; SIDHU ALBAN; ROUBERT PIERRE; THURIEAU CHRISTOPHE
权利人:IPSEN PHARMA
摘要:The invention concerns novel 5-sulphanyl-4H-1,2,4-triazole derivatives of formula (I), wherein: R1, R2 and R3 represent variable groups and the methods for preparing them by liquid-phase parallel synthesis processes. Said product exhibit good affinity for certain sub-types of somatostatin receptors; they are particularly useful for treating pathological conditions or diseases wherein one (or more) somatostatin receptors is (are) involved. The invention also concerns pharmaceutical compositions containing said products and their use for preparing a medicine.

专利号:EP-0030023-A2
优先权日:1979-11-30
标题:A heterocyclic compound and its synthesis, pharmaceutical formulations thereof and the use of the compounds and the formulations in medicine