CAS: 604-44-4; 4-Chloronaphthalen-1-Ol

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📜1-羟基-2-萘甲酸置于溶剂黄146,硝基苯,苯胺体系中,化学反应生成 4-氯-1-萘酚
参考文献:Artifactual Thickening Of The Sinus Walls On Computed Tomography: A Phantom Model And Clinical Study
标题:Artifactual Thickening Of The Sinus Walls On Computed Tomography: A Phantom Model And Clinical Study
摘要:在计算机断层扫描上测量鼻窦壁厚度可能对于区分鼻窦急性和慢性炎症或疑似肿瘤的情况非常重要.本研究的目标是研究充气和通气的鼻窦对鼻窦壁厚度外观的影响.使用半浸入水中的头骨模型进行扫描,并使用不同的切片厚度和不同的窗口.水浸入侧的鼻窦壁似乎比通气侧的鼻窦壁更厚.骨窗口不能完全消除这种部分体积效应.结论是,将充满液体或组织的鼻窦与充满空气的对应部位进行比较并不足够准确以评估鼻窦壁厚度.骨窗口不能完全消除充满液体的鼻窦骨壁的人工增厚.
DOI:10.1177/000348940010900914

专利信息

专利号:US-5556963-A
优先权日:1994-08-05
标题 :Synthesis of 4-alkoxy-N-acetylneuraminic acid
发明人：LIAV AVRAHAM; HARDGRAVE RAGEN F; BLYSTONE SHERI; TURNER GREGORY A
权利人:OKLAHOMA MED RES FOUND
摘要:This invention relates to an improved process for the synthesis of 4-alkoxy-N-acetylneuraminic acids. According to the process of the invention, N-acetylneuraminic acid is first alkylated at C-1 and C-2 and then the vicinal hydroxyl groups at C-8 and C-9 are protected through the formation of a ketal. The resulting protected alkyl ester alkyl ketoside is then alkylated at the C-4 position whereby the hydrogen of the C-4 hydroxyl group is replaced with an alkyl group to form an alkoxy group. Deprotection is accomplished through the removal of the ketal group at C-8 and C-9 and removal of the alkyl groups at C-1 and C-2, thereby producing the 4-alkoxy-N-acetylneuraminic acid.

专利号:US-6376475-B1
优先权日:1997-05-30
标 题 :Control of immune responses by modulating activity of glycosyltransferases
发明人：MARTH JAMEY D; PAULSON JAMES C
权利人:ABARON BIOSCIENCES INC; UNIV CALIFORNIA
摘要:The invention provides methods for inhibiting immune responses by inhibiting the biosynthesis of the sialyl galactosides that are involved in immune responses. In particular, B lymphocyte-mediated immune responses are mediated by interfering with synthesis of α2,6 sialylgalactosides, while T lymphocyte-mediated immune responses are inhibited by blocking synthesis of α2,3 sialylgalactosides. The inhibition is accomplished by, for example, inhibiting the activity of a glycosyltransferase involved in synthesis of the respective sialyl galactoside.

专利号:US-7338932-B2
优先权日:2000-05-11
标题 :Methods of modulating functions of polypeptide GalNAc-transferases and of screening test substances to find agents herefor, pharmaceutical compositions comprising such agents and the use of such agents for preparing medicaments
发明人：CLAUSEN HENRIK; BENNETT ERIC PAUL; HASSAN HELLE; REIS CELSO ALBUQUERQUE
权利人:GLYCOZYM APS
摘要:Attachment of O-glycans to proteins is controlled by a large family of homologous polypeptide GalNAc-transferases. Polypeptide GalNAc-transferases contain a C-terminal sequence with similarity to lectins. This invention discloses that the putative lectin domains of GalNAc-transferase isoforms, GalNAc-T4, -T7, -T2, and -T3, are functional and recognize carbohydrates, glycopeptides, and peptides and discloses the lectin domains of GalNAc-T1-T16. These lectin domains have different binding specificities and modulate the functions of GalNAc-transferase isoforms differently. Novel methods for identification of inhibitors or modulators of binding activities mediated by lectin domains of polypeptide GalNAc-transferases are disclosed. Direct binding activity of GalNAc-transferase lectins has been demonstrated for the first time and methods to measure lectin mediated binding of isolated lectins or enzymes with lectin domains are disclosed. The present invention specifically discloses a novel selective inhibitor of polypeptide GalNAc-transferase lectin domains, which provides a major advancement in that this inhibitor and related inhibitors sharing common characteristics of activity bind lectin domains without serving as acceptor substrate for glycosyltransferases involved in synthesis of O-glycans. This inhibitor is represented by the β-anomeric configuration of GalNAc-benzyl, GalNAcβ-benzyl. Methods for inhibiting intracellular transport, cell surface expression, and secretion of mucins and O-glycosylated glycoproteins without affecting O-glycosylation processing are disclosed using the novel selective inhibitor identified.

专利号:US-6350612-B1
优先权日:1986-01-28
标 题 :Isolation and expression of DNA sequence encoding the five subunits of Bordetella pertussis toxin
发明人：RAPPUOLI RINO; NICOSIA ALFREDO; ARICO MARIA BEATRICE
权利人:CHIRON SPA
摘要:Cloning and sequencing of the Eco RI fragment of B. pertussis chromosomal DNA with 4696 base pairs, containing the genes which code for the five subunits of the pertussis toxin. A hybrid plasmid containing the DNA fragment or its further fragments and a micro-organism transformed by the hybrid plasmid and capable of expressing the cloned DNA fragment or further fragments thereof by synthesis of the pertussis toxin or one or more subunits of the pertussis toxin. The pertussis toxin or one or more subunits of the pertussis toxin so obtained are useful for the preparation of vaccines and diagnostic kits.

专利号:EP-1558728-B1
优先权日:2002-11-08
标 题:Methods to identify agents modulating functions of polypeptide galnac-transferases, pharmaceutical compositions comprising such agents and the use of such agents for preparing medicaments
发明人：CLAUSEN HENRIK; BENNETT ERIC PAUL
权利人:GLYCOZYM APS
摘要:Novel methods for identification of inhibitors or modulators of binding activities mediated by lectin domains of polypeptide GalNAc-transferases are disclosed. Direct binding activity of GalNAc-transferase lectins has been demonstrated for the first time and methods to measure lectin mediated binding of isolated lectins or enzymes with lectin domains are disclosed. The present invention specifically discloses a novel selective inhibitor of polypeptide GalNAc-transferase lectin domains, which provides a major advancement in that this inhibitor and related inhibitors sharing common characteristics of activity bind lectin domains without serving as acceptor substrate for glycosyltransferases involved in synthesis of O-glycans. This inhibitor is represented by the O-anomeric configuration of GalNAc-benzyl, GalNAcbeta-benzyl. Methods for inhibiting intracellular transport, cell surface expression, and secretion of mucins and O-glycosylated glycoproteins without affecting O-glycosylation processing are disclosed using the novel selective inhibitor identified.

专利号:US-5670698-A
优先权日:1996-08-19
标 题:Synthesis of 1-acetoxy-2-methylnaphthalene
发明人：LIM MU-ILL; PAN YUH-GUO; STASAITIS LINAS; ANDERSON JAMES
权利人:BRISTOL MYERS SQUIBB CO
摘要:A one pot process is provided in which a Mannich base of the formula 5 is reacted with acetic anhydride to produce a diacetate derivative. Without any intermediate isolation, the derivative is hydrogenated to produce a reaction mixture containing 1-acetoxy-2-methylnaphthalene which is readily precipitated from the reaction mixture by addition of water. ##STR1##