CAS: 5945-86-8; Nimbin

该化合物是天然存在的碱性物质,主要见于植物叶子*Nimba*(Azadirachta indica),通称为neem,该化合物以多种生物活动闻名,包括抗微生物,抗炎和杀虫特性,使其对药理学和农业应用都感兴趣.Nimbin展示了一个复杂的分子结构,有助于其与各种生物目标互动的能力.它经常被研究其潜在的治疗作用,特别是在传统医学中,该物质已经使用了数百年Neem.该物质的特点通常是其有机溶剂中的溶性,水溶性有限,在不同制剂中影响其生物利用率和功效.此外,硝宾的安全情况和环境影响是正在进行的研究的主题,特别是在可持续农业和自然虫害控制方面.

结构式图片

上下游产品

印苦楝内酯 Nimbolide 25990-37-8
脱乙酰基印楝素 6-Deacetylnimbin 18609-16-0

合成工艺路线路线简述

    📜脱氢枞酸甲酯置于吡啶,4-二甲氨基吡啶,Selenium(Iv) Oxide,Aluminum (Iii) Chloride,Potassium Osmate(Vi) Dihydrate,双[α,α-双(三氟甲基)苯甲醇合]二苯硫,偶氮二异丁腈,Pyridine Hydrofluoride,三氟甲磺酸三甲基硅酯,三正丁基氢锡,Sodium Methylate,甲基(三氟甲基)-1,3-二环氧丙烷,L-Selectride,Potassium Carbonate,对甲苯磺酸,臭氧,N-甲基吗啉氧化物,三乙胺,间氯过氧苯甲酸,三氟乙酸体系中,用 四氢呋喃,1,4-二氧六环,甲醇,氟苯,六氟苯,二氯甲烷,氯仿,水,丙酮,甲苯,乙腈,1,1,2,2-四氯乙烷 作为反应溶剂,化学反应 114.9H,反应生成 印楝素
    参考文献: Nimbolide Analogs And Methods Of Use Thereof[fr] Analogues De Nimbolide Et Leurs Méthodes D'Utilisation
    标题: Nimbolide Analogs And Methods Of Use Thereof[fr] Analogues De Nimbolide Et Leurs Méthodes D'Utilisation
    摘要:Disclosed Herein Are Compounds Of The Formula (I) Or (II) Wherein The Variables Are Defined Herein. Also Provided Are Methods Of Manufacturing And Pharmaceutical Compositions Thereof. In Some Aspects,The Compounds And Compositions Provided Herein May Be Used As Parp1 Inhibitors. In Some Aspects,The Present Disclosure Provides Methods Wherein The Compounds And Compositions Described Herein Are Used For The Treatment Of Diseases And Disorders,Such As Cancer.

    海关参考信息

    专利信息


    专利号:WO-9219616-A1
    优先权日:1991-05-06
    标题 :Improvements of a pesticidal/insect repellent comprising synthesis of a new pesticidal insect repellent
    发明人:GUERRINI VINCENT HENRY
    权利人:GUERRINI VINCENT HENRY
    摘要:There is provided a novel method to improve the pesticidal and repellent properties of neem extracts or azadirachtin containing compositions comprising the synthesis of a new pesticide repellent. Neem extracts containing azadirachtins or compositions containing neem extracts or neem extracts with azadirachtins, dialkyltoluamides and volatile oils are heated between 30 and 200 degrees centigrade from 1 second to 1000 hours to improve the pesticidal and repellent properties of the compositions or synthesize new pesticides or insect repellents.

    专利号:WO-2020121335-A1
    优先权日:2018-12-14
    标题:A process for producing tirucalladienol for synthesis of limonoids
    发明人:HIREKODATHAKALLU VENKATARAMAIAH THULASIRAM; PANDREKA AVINASH; PATIL CHAYA SHIVANAGOUDA
    权利人:COUNCIL SCIENT IND RES
    摘要:The invention relates to the construction of recombinant DNA constructs encoding tirucalladienol synthase; and squalene epoxidase operably linked to a regulatory sequence. The production of tricualldienol in a yeast is increased by coexpression with squalene epoxidase. Further, tirucalladeinol synthase engineering leads to increase in the efficiency of the synthesis process towards tirucalladienol.

    专利号:CN-111944797-A
    优先权日:2020-08-25
    标 题 :A related gene of a key intermediate in the synthesis of azadirachtin

    专利号:CN-101205222-A
    优先权日:2006-12-20
    标 题:Total synthesis of Rocaglamide and uses thereof as insecticidal agent

    专利号:CN-101215526-B
    优先权日:2008-01-15
    标 题 :Cell culturing method for accelerating synthesis of glossy ganoderma secondary metabolite

    专利号:CN-101215526-A
    优先权日:2008-01-15
    标题:Cell culturing method for accelerating synthesis of glossy ganoderma secondary metabolite

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    📌 第三方产品分析报告

    ✅ COA系统入驻 | 共享模式

    合成参考文献


    参考文献:10.1002/ps.449
    摘要:Salehzadeh A, Jabbar A, Jennens L, Ley SV, Annadurai RS, Adams R, Strang RH. The effects of phytochemical pesticides on the growth of cultured invertebrate and vertebrate cells. Pest Manag Sci. 2002 Mar;58(3):268–76. doi: 10.1002/ps.449.
    参考文献:10.1002/ps.834
    摘要:Simmonds MS, Jarvis AP, Johnson S, Jones GR, Morgan ED. Comparison of anti‐feedant and insecticidal activity of nimbin and salannin photo‐oxidation products with neem (Azadirachta indica) limonoids. Pest Management Science. 2004 Jan 05;60(5):459–64. doi: 10.1002/ps.834.
    参考文献:10.1021/jf025534t
    摘要:Suresh G, Gopalakrishnan G, Wesley SD, Pradeep Singh ND, Malathi R, Rajan SS. Insect antifeedant activity of tetranortriterpenoids from the Rutales. A perusal of structural relations. J Agric Food Chem. 2002 Jul 31;50(16):4484–90. doi: 10.1021/jf025534t.
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