📜正己醛置于ammonium Chloride,乙酸酐体系中,用 正己烷,乙酸乙酯,甲苯 作为反应溶剂,以83%的收率获得产物乙酸3-辛酯 参考文献:Catalysts For Asymmetric Addition Of Organozinc Reagents To Aldehydes And Method For Preparation 标题:Catalysts For Asymmetric Addition Of Organozinc Reagents To Aldehydes And Method For Preparation 摘要:提供了新型手性氨醇催化剂及其制备方法.第一种催化剂是通过对前体中的两个苯环中的一个进行选择性氢化制备的.氨醇促进有机锌试剂对醛的不对称加成,以得到光学活性醇或其酯.第二种催化剂是通过3-外共轭氨基异藁醇与2-卤乙基醚的选择性二烷基化制备的.氨醇促进对含有β-支链的脂肪族醛的有机锌试剂的加成,相对于daib具有大大增强的对映选择性.
专利号:US-8455655-B2 优先权日:2010-05-07 标题:Preparation of dihydropyridines 发明人:VISHNU NEWADKAR RAVINDRANATH; PURUSHOTTAM JOSHI ANIL; KUMAR SINGH SANTOSH 权利人:VISHNU NEWADKAR RAVINDRANATH; PURUSHOTTAM JOSHI ANIL; KUMAR SINGH SANTOSH; LESVI LABORATORIOS SL 摘要:The invention relates to a method and compounds for the preparation of clevidipine butyrate, a very short acting hypertensive calcium antagonist, as well as the synthesis of these compounds useful for the preparation of clevidipine (also known as clevidipine butyrate). Moreover the invention also discloses polymorphic forms of clevidipine butyrate, useful for the preparation of pharmaceutical compositions, and processes to prepare them.
专利号:US-2019276389-A1 优先权日:2015-12-18 标题:Synthesis of aryl cyclohexane ester derivatives useful as sensates in consumer products 发明人:WOS JOHN AUGUST; YELM KENNETH EDWARD; BUNKE GREGORY MARK; FREDERICK HEATH ALAN; REILLY MICHAEL; HAUGHT JOHN CHRISTIAN; SREEKRISHNA KOTI TATACHAR; LIN YAKANG 权利人:PROCTER & GAMBLE 摘要:Personal care compositions, such as oral care and skin care compositions containing a flavor/perfume system comprising one or more coolants. The pleasant cool sensation provided by a coolant is enhanced in terms of quicker onset, greater intensity, impact or longer duration, which improves appeal and acceptability of the compositions to consumers.
专利号:US-4794108-A 优先权日:1984-04-24 标题:1-carboxymethoxy acetidinones and their production 发明人:KISHIMOTO SHOJI; SENDAI MICHIYUKI; OCHIAI MICHIHIKO 权利人:TAKEDA CHEMICAL INDUSTRIES LTD 摘要:A 2-azetidinone derivative having a group of the formula wherein R1 and R2 are the same or different and each represents a hydrogen atom, alkyl, aryl or arylalkyl which may have a substituent at the 1-position and an amino group, at the 3-position, which may be acylated or protected, its salt or ester, and methods of producing the same, (1) a method comprising subjecting a 2-azetidinone derivative having a group of the formula wherein the symbols are as defined above at the 1-position and an amino group at the 3-position, its salt or ester to an acylation or protective-group introduction reaction, and (2) a method comprising reacting a 2-azetidinone derivative having a hydroxy group at the 1-position and an amino group, at the 3-position, which may be acylated or protected, or its salt with a compound of the formula wherein W is a halogen atom; other symbols are as defined above, its salt or ester. The above objective compounds are utilizable as excellent antimicrobial agents or as valuable intermediates for the synthesis of the same.
专利号:AU-2016371908-A1 优先权日:2015-12-18 标题 :Synthesis of cyclohexane ester derivatives useful as sensates in consumer products
专利号:CA-3007767-A1 优先权日:2015-12-18 标题:Synthesis of cyclohexane ester derivatives useful as sensates in consumer products
参考文献:10.2478/s11535-012-0077-5 摘要:Kremer D, Müller I, Dunkić V, Vitali D, Stabentheiner E, Oberländer A, Bezić N, Kosalec I. Chemical traits and antimicrobial activity of endemic Teucrium arduini L. from Mt Biokovo (Croatia). 2012 Aug 03;7(5):941–7. doi: 10.2478/s11535-012-0077-5. 参考文献:10.1007/978-3-031-21219-2_191 摘要:Rudoy D, Olshevskaya A, Magomedov M, Pavlov P, Odabashyan M, Krasavin E. Agrobiotechnology of Essential Oil Crops on the Example of Peppermint (Mentha Piperita). 2023. In: Lecture Notes in Networks and Systems. 参考文献:10.1007/978-981-19-2734-8_8 摘要:Tiwari VK, Kumar A, Rajkhowa S, Tripathi G, Singh AK. Enzymes in Organic Synthesis. 2022. In: Green Chemistry. 参考文献:10.1134/s1061934823090095 摘要:Nazarova DV, Temerdashev ZA, Vinitskaya EA, Kiseleva NV, Nagalevskii MV. Comparative Analysis of Chemical Compositions of Mentha L. Plant Extracts by Gas Chromatography–Mass Spectrometry after Hydrodistillation and Subcritical Extraction. J Anal Chem. 2023 Sep;78(9):1174–83. doi: 10.1134/s1061934823090095. 参考文献:10.1007/s11101-024-10020-6 摘要:Hedayati S, Tarahi M, Baeghbali V, Tahsiri Z, Hashempur MH. Mint (Mentha spp.) essential oil extraction: from conventional to emerging technologies. Phytochem Rev. 2024 Sep 17;24(4):3157–78. doi: 10.1007/s11101-024-10020-6.