CAS: 434-05-9; Methenolone Acetate

该化合物是一种合成的代谢和诱杀性类固醇(AAS),产自二氢苯酯酮(DHT),化学定性为1-甲基-1-二氢苯酮乙酸酯,具有中度新陈代谢效应,活动相对较低,并且具有诱发性;该化合物由于乙酸酯酯酯而口服,提高了生物利用率;甲醇酮乙酸酯主要用于临床环境,治疗涉及肌肉消瘦,贫血和骨质疏松塞的条件,因为它能刺激蛋白合成和骨质红素;其有利的亚化-亚素-和色素比率降低了治疗应用中的病毒化风险;乙酸酯确保了较短的半衰期,允许更受控制的剂量.稳定性和可预见的药基酸性使该物质成为使用和基因替代疗法的可靠选择.

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CAS号1099-80-5 17β-acetoxy-1-m...

合成工艺路线路线简述

    17β-Acetoxy-1-Methyl-Androsta-1,4-Dien-3-One置于thallium(Iii) Nitrate Trihydrate体系中,用 二乙二醇二甲醚 作为反应溶剂,化学反应 24.0H,以8%的收率获得产物美替诺龙醋酸酯
    参考文献:Torrini; Romeo,Farmaco,Edizione Scientifica,1980,Vol. 35,# 8,P. 681-683
    标题:Torrini; Romeo,Farmaco,Edizione Scientifica,1980,Vol. 35,# 8,P. 681-683

    海关参考信息

    专利信息


    专利号:US-2013035307-A1
    优先权日:2010-01-26
    标 题:Methods for treating or preventing the spread of cancer using semi-synthetic glycosaminoglycosan ethers
    发明人:PRESTWICH GLENN D; KENNEDY THOMAS P
    权利人:UNIV UTAH RES FOUND; PRESTWICH GLENN D; KENNEDY THOMAS P
    摘要:Described herein are methods for the treatment and prevention of tumor metastasis using alkylated and fluoroalkylated semi-synthetic glycosaminoglycan ethers (“SAGEsâ€?). The synthesis of sulfated alkylated and fluoroalkylated SAGEs is also described.

    专利号:US-2014274978-A1
    优先权日:2013-03-15
    标题 :Phytosterol spirostane and spirostene derivatives having a wide variety of utilities in humans and other animals
    发明人:FASCIOLA ANDRE ARMEL
    权利人:FASCIOLA ANDRE ARMEL
    摘要:The present invention utilizes phytosterol, phytoecdysteroid, sapogenin, triterpene, terpene, spirostane, spirostene and androstene derivative compounds to provide a wide variety of utilities to humans and other animals. The compounds and methods provide numerous and wide-ranging benefits including biochemical and constructive metabolic benefits including increases in protein synthesis and synthesis efficiency, ergogenic, adaptogenic, cosmetic and medicinal skin agents and veterinary utilities. The compounds provide agents that increase physical endurance and work output, act as a general tonic for increasing health and vigor, increase sleep time and sleep efficiency and act as rejuvenating agents to reverse the effects of fatigue and stress. Novel utilities for pet, farm, zoo and companion animals are also provided.

    专利号:US-2025281509-A1
    优先权日:2021-04-26
    标 题 :Sequential hormone therapy to improve survival and enhance response to immune therapy in men with prostate cancer
    发明人:DENMEADE SAMUEL R; ISAACS JOHN T; ANTONARAKIS EMMANUEL S; KACHHAP SUSHANT; MARKOWSKI MARK CHRISTOPHER
    权利人:UNIV JOHNS HOPKINS
    摘要:Disclosed are methods for treating men with castrate resistant prostate cancer with a sufficient dose of testosterone to achieve supraphysiologic serum levels of testosterone in sequence with androgen ablative treatment or androgen synthesis inhibitors for one or more cycles until evidence of radiographic progression, at which point the subject will receive immune checkpoint blockade therapy.

    专利号:US-2014315720-A1
    优先权日:2012-10-24
    标 题 :Polysaccharide ester microspheres and methods and articles relating thereto
    发明人:FALLON DENIS G; GARRETT THOMAS S; KIZER LAWTON E; ZAZZARA KAREN L; COMBS MICHAEL T; JOHNSON RICHARD K; DEHART GARY
    权利人:CELANESE ACETATE LLC
    摘要:A method for producing a polysaccharide ester microsphere may include forming a polysaccharide ester product from a polysaccharide synthesis, wherein the polysaccharide ester product comprises a polysaccharide ester and a solvent; diluting the polysaccharide ester product, thereby yielding a polysaccharide ester dope; and forming a plurality of polysaccharide ester microspheres from the polysaccharide ester dope. Suitable polysaccharides may include, but are not limited to, starch, cellulose, hemicellulose, algenates, chitosan, and any combination thereof. Esters thereof may be organic esters (e.g., acetate and the like), inorganic esters (e.g., sulfonates and the like), or combinations thereof. Further, the solids conent of the polysaccharide ester dope, in some instances, may be greater than about 16 wt %.
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    合成参考文献


    摘要:Drugs in Japan, -(1370), 1995
    摘要:S109 | PARCEDC | List of 7074 potential endocrine disrupting compounds (EDCs) by PARC T4.2 | DOI:10.5281/zenodo.10944198
    摘要:S72 | NTUPHTW | Pharmaceutically Active Substances from National Taiwan University | DOI:10.5281/zenodo.3955664
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