1,6-己二醇置于potassium Permanganate,硫酸,氢溴酸体系中,化学反应生成 6-溴己酸 参考文献:Synthesis And Biological Activities Of Acetylenic Fatty Acids And Their Esters 标题:Synthesis And Biological Activities Of Acetylenic Fatty Acids And Their Esters 摘要:通过邻硝基苯硒醚合成了 8 种末端炔脂肪酸:从 5-己炔酸到 12-十三炔酸及其甲基,乙基和异丙基酯.这些酸和酯对莴苣种子萌发和幼苗生长均有抑制作用.其作用效果依赖于炔链碳原子数.8-壬炔酸具有强烈的活性,其甲酯在所测试样品中活性最强.此外,这些酸具有抗菌活性,且随碳原子数的增加而增强. DOI:10.1246/bcsj.59.3535
专利号:US-2024229089-A1 优先权日:2021-04-30 标 题 :A process for enzymatic synthesis of amides from amines and carboxylic acids or esters 发明人:LIN SHUANGZHENG; CORDOVA ARMANDO; DEIANA LUCA; IBRAHEM ISMAIL 权利人:XP CHEMISTRIES AB 摘要:The present invention relates to A process for enzymatic synthesis of amides of formula (III) from amines of formula (I) and compounds of formula (II). characterized in that the lipase is immobilized on a rotary bed reactor or on a spin-fixed-bed reactor and a Dean-Stark apparatus is used for dehydration.
专利号:EP-1383732-B1 优先权日:2001-05-04 标题:Labelling reagents, method for synthesis of said reagents and methods for detecting biological molecules 发明人:BOURGET CECILE; LHOMME JEAN; LAAYOUN ALI; KOTERA MITSUHARU; TREVISIOL EMMANUELLE; MENOU LIONEL; BERNAL MENDEZ ELOY 权利人:BIO MERIEUX; UNIV GRENOBLE 1; CENTRE NAT RECH SCIENT 摘要:The invention concerns a temperature-stable labelling reagent of formula (I), wherein: R<1> represents H or an alkyl, aryl or substituted aryl group; R<2> represents a detectable marker or at least two detectable markers linked together by at least a multimeric structure; L is a linking arm comprising a linear catemer concatenation of at least two covalent bonds; and n is an integer equal to 0 or 1; R<3> and R<4> represent, independently of each other: H, NO2, Cl, Br, F, I, R<2>-(L)n-Y-X-, OR, SR, NR2, R, NHCOR, CONHR, COOR with R = alkyl or aryl, A is a linking arm comprising at least a double bond enabling the conjugation of the diazo function with the aromatic cycle; and u is a whole number between 0 and 2, preferably between 0 and 1; and -Y-X- represents -CONH-, -NHCO-, -CH2O-, -CH2S-. The invention also concerns a method for the synthesis of said markers and uses for labelling biological molecules, in particular nucleic acids, with a labelling reagent bearing the diazomethyl function. The invention is particularly applicable in the field of diagnosis.
专利号:US-2021369846-A1 优先权日:2018-10-26 标 题 :New Ammonium Salts Of Fluorinated Organic Acids, Method Of Their Synthesis and Application 发明人:STEFANEK AGATA; CIACH TOMASZ; LECZYCKAWILK KATARZYNA; CZARNOCKA-SNIADALA SYLWIA; GRAFSTEIN JOANNA; DRESLER MAGDALENA; NOWAK ALEKSANDRA; WGLINKSKI JAKUB 权利人:NANOSANGUIS 摘要:The exemplary arrangements relate to ammonium salts of partially fluorinated organic acids. The exemplary arrangements also relate to methods of synthesis of the ammonium salts of partially fluorinated organic acids. The exemplary arrangements also relate to methods of use of the ammonium salts of partially fluorinated organic acids to produce stabilizing emulsions of the oil-in-water and/or water-in-oil type. The exemplary arrangements also relate to methods of use and applications of the ammonium salts of partially fluorinated organic acids, for example use as stabilizing agents in blood substitute preparations.
专利号:US-6841559-B1 优先权日:1999-11-19 标 题:Pyridinones to treat and prevent bacterial infections 发明人:ALMQVIST FREDERIC; EMTENAS HANS; HULTGREN SCOTT J; PINKNER JEROME S 权利人:WASHINGTON UNIVERSITY OF ST LO 摘要:Novel pyridinones and their derivatives which are effective in treating or preventing Gram-negative bacterial infections are provided. The pyridinones are stable and easily derivatized; the methods by which these derivatizations occur is described. Two regioselective and functional group tolerant methods for the synthesis of the novel pyridinones are also provided. One such synthetic method involves reacting an imine and a Meldrum's acid derivative in solution. The other synthetic method is a solid phase synthesis of the pyridinones in which an imine is prepared bound to a solid support and a Meldrum's acid derivative is reacted with the imine. Novel imine intermediates useful in the solid phase and solution methods of synthesizing the pyridionones are also described.
专利号:US-7408075-B1 优先权日:2005-03-23 标 题:Synthesis of phosphocholine ester derivatives and conjugates thereof 发明人:REZANKA LOUIS J 权利人:US HEALTH 摘要:Aspects of the present invention include methods of synthesizing phosphocholine analogues and the phosphocholine conjugates formed therefrom and their use in preventing infections caused by microorganisms.
专利号:US-12441760-B2 优先权日:2013-08-29 标 题 :Amino diacids containing peptide modifiers 发明人:BARLOS KLEOMENIS; GATOS DIMITRIOS; BARLOS KOSTAS K; VASILEIOU ZOI 权利人:CHEMICAL & BIOPHARMACEUTICAL LABORATORIES OF PATRAS S A 摘要:The present invention relates to peptide modifier compounds of Formula (1), or a salt thereof, wherein: a is an integer from 1 to 10, more preferably from 1 to 3; b is an integer from 0 to 7; Z is a terminal group and Y is a bivalent group. Further aspects of the invention relate to intermediates in the preparation of compounds of Formula (1), and the use of compounds of Formula (1) in the synthesis of peptide derivatives.
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合成参考文献
参考文献:10.1038/ncomms1384 摘要:Deng S, Zhang Y, Brozena AH, Mayes ML, Banerjee P, Chiou WA, Rubloff GW, Schatz GC, Wang Y. Confined propagation of covalent chemical reactions on single-walled carbon nanotubes. Nat Commun. 2011 Jul 12;2():382. doi: 10.1038/ncomms1384.