CAS: 138021-87-1; Fmoc-Cys(Me)-Oh

相似化合物

1187-84-4 7728-98-5 16947-80-1

上下游产品

CAS号1187-84-4 S-甲基-L-半胱氨酸 | CAS号28920-43-6 芴甲氧羰酰氯(Fm°C-Cl)

📜Alkaline Earth Salt Of/the/ Methylsulfuric Acid置于trifluoroacetate体系中,用 二氯甲烷,水 用作溶剂,化学反应生成N-芴甲氧羰基-S-甲基-L-半胱氨酸
参考文献:Sc(otf)3介导的硫醚的轻度和高度化学选择性氧化.
标题:Sc(otf)3介导的硫醚的轻度和高度化学选择性氧化.
摘要:[反应:见正文]催化sc(otf)(3)大大提高了过氧化氢介导的烷基芳基硫醚和甲基半胱氨酸肽的单氧化效率.该方法收率高,可与许多广泛使用的保护基团兼容,适用于固相应用,且过氧化反应最少.
Doi:10.1021/ol026947I

专利信息

专利号:US-10442838-B2
优先权日:2015-12-18
标 题 :Linaclotide synthesis method
发明人：CHEN XUEMING; WU JINGKANG; MI PENGCHENG; TAO ANJIN; YUAN JIANCHENG
权利人:HYBIO PHARMACEUTICAL CO LTD
摘要:Disclosed is a method of synthesizing linaclotide through completely selective formation of three disulfide bonds, comprising the steps of: 1) synthesizing linaclotide precursor resin through solid-phase synthesis; 2) forming the first disulfide bond through solid phase oxidation; 3) forming the second disulfide bond through liquid phase oxidation; and 4) deprotecting methyl in the methyl-protected cysteine, and oxidatively coupling the third disulfide bond to obtain linaclotide. The method has mild reaction conditions with low cost, high yield and high purity product, is a simple and stable process and is suitable for large-scale production.

专利号:US-8349899-B1
优先权日:2008-12-03
标题:Selective inhibitors of EG5 motors and methods of use
发明人：ARTERBURN JEFFREY; SHUSTER CHARLES
权利人:ARROWHEAD CT INC; ARTERBURN JEFFREY; SHUSTER CHARLES
摘要:Embodiments of the present invention comprises a compound of formula I or its enantiomer, diastereomer, stereoisomer or its pharmaceutically acceptable salt, methods of use and methods of synthesis.

专利号:US-8765817-B1
优先权日:2008-12-03
标题 :Selective inhibitors of EG5 motors and methods of use
发明人：ARTERBURN JEFFREY; SHUSTER CHARLES B
权利人:ARROWHEAD CT INC
摘要:Embodiments of the present invention comprises a compound of formula I or its enantiomer, diastereomer, stereoisomer or its pharmaceutically acceptable salt, methods of use and methods of synthesis.

专利号:CN-106892968-B
优先权日:2015-12-18
标 题:Synthesis method of linaclotide