CAS: 129830-38-2; Trans-4-((R)-1-Aminoethyl)-N-(Pyridin-4-yl)Cyclohexanecarboxamide Dihydrochloride

上下游产品

trans-tert-butyl (R)-1-[4-(pyridin-4-ylcarbamoyl)cyclohexyl]ethylcarbamate 4-aminopyridine bis-1,4-(hydroxymethyl)cyclohexane trans-[4-(tert-butyl-dimethyl-silanyloxymethyl)-cyclohexyl]-methanol

专利信息

专利号:US-2025043248-A1
优先权日:2023-08-04
标题:Preparation method and use of hydrogel material for growth of blood vessel organoids
发明人：SUN DI; SUN JIAMING; WANG ZHENXING; LEI SHIZE
权利人:UNION HOSPITAL TONGJI MEDICAL COLLEGE HUST
摘要:The present disclosure provides a preparation method and use of a hydrogel material for growth of blood vessel organoids (BVOs). The preparation method of the hydrogel material includes: (1) synthesis of gelatin methacryloyl (GelMA), and (2) synthesis of ns-GelMA-PEO. The hydrogel material may be used for in vitro cultivation of BVOs. The hydrogel material ns-GelMA-PEO prepared by the present disclosure may significantly improve the survival and budding abilities of BVOs. The ns-GelMA-PEO provides a novel solution for in vitro cultivation of BVOs, and may well support the growth and differentiation of organoids.

专利号:US-2024052097-A1
优先权日:2021-02-08
标题 :Synthesis of peg-based thiol-norbornene hydrogels with tunable hydroylitic degradation properties
发明人：LIN CHIEN-CHI; LIN FANG-YI
权利人:UNIV INDIANA TRUSTEES
摘要:Methods for synthesizing a hydrogel having tunable hydrolylic degradation kinetics according to certain embodiments include synthesizing a norborene-functionalized polyethylene glycol macromer having an ester linkage between a polyethylene glycol domain of the macromer and a norbornene domain of the macromer and having a carboxyl group on the norbornene; and reacting a quantity of such macromers with a quantity of dithiol molecules by an ultraviolet-initiated photo-gelation reaction to yield a hydrogel. Such macromers and such hydrogels form additional aspects of the disclosure, as do a wide variety of methods for tuning and for using such hydrogels.

专利号:US-2023096053-A1
优先权日:2019-12-06
标 题:Genetically-targeted chemical assembly: building functional structures and materials in living cells, tissues, and animals
发明人：DEISSEROTH KARL A; BAO ZHENAN; LIU JIA; RAMAKRISHNAN CHARU; KIM YOON SEOK; TOM ARIANE C
权利人:UNIV LELAND STANFORD JUNIOR
摘要:Compositions and methods are provided for genetically modifying cells to guide in situ chemical synthesis of electroactive, conductive, or insulating polymers on plasma membranes, organelle membranes, or subcellular surfaces of cells. In particular, compositions and methods are provided for genetically modifying excitable cells such as neurons, muscle cells, and endocrine cells to guide in situ chemical synthesis of polymers on the extracellular side of the plasma membrane. The subject methods can be used in various applications, for example, to assemble polymers in vivo at targeted locations to modulate electrical conduction and create new electrical conduction pathways, allow cell-type-specific neuromodulation, provide a conductive structure on cells for connection to electrodes, sensors, or other external electronic and electrochemical devices, and create a durable structure to replace damaged tissue for use in regenerative medicine.

专利号:WO-2022170012-A1
优先权日:2021-02-08
标 题:Synthesis of peg-based thiol-norbornene hydrogels with tunable hydroylitic degradation properties

专利号:EP-4580642-A2
优先权日:2022-09-01
标 题 :Genetically engineered cd4 t-cells for in situ synthesis of proteins

专利号:US-12435312-B2
优先权日:2022-02-28
标 题 :Quantifying cell-derived changes in collagen synthesis, alignment, and mechanics in a 3D connective tissue model
发明人：MORGAN JEFFREY R; WILKS BENJAMIN T
权利人:UNIV BROWN
摘要:Described herein are in vitro quantitative methods directed to 3D extracellular matrix (ECM) organization and mechanics. The methods do not require application of an external force, anchorage, or a scaffolding material in order to culture ECM tissue constructs, and the methods enable quantitative measurements without crosstalk noise from variables attributable to external forces, anchorage, and scaffolding material.