CAS: 1144-74-7; 4-Nitrobenzophenone

相似化合物

52898-51-8 1137-41-3 40292-15-7

上下游产品

benzophenone 4-benzyl-1-nitrobenzene 1-(diphenylmethyl)-4-nitrobenzene benzophenone; nitrate 1-(4-nitro-phenyl)-1-phenyl-penta-2,4-diyn-1-ol bis-(4-benzoyl-phenyl)-diazene 4-nitro-benzophenone-(2,4-dinitro-phenylhydrazone) 1-(4-nitrophenyl)-1-phenylethylene

2-苯基乙酰苯胺置于potassium Tert-Butylate体系中,用 二甲基亚砜,苯 用作溶剂,化学反应 16.0H,反应生成4-硝基二苯甲酮
参考文献:Sp 3和sp 2 C-h键的无过渡金属氧化交叉偶联反应合成不对称的二芳基乙酰胺,苯并呋喃,苯甲酮和x吨.
标题:Sp 3和sp 2 C-h键的无过渡金属氧化交叉偶联反应合成不对称的二芳基乙酰胺,苯并呋喃,苯甲酮和x吨.
摘要:甲化疗和区域选择性的分子间的sp 3 C-H和sp 2 C-H偶合反应为c-C键的形成是从tm-自由条件下描述访问非对称的二芳基乙酰胺仲-和叔-Arylacetamides以及使用硝基芳烃叔室温下在dmso中的-丁氧基碱.具有敏感官能团(例如氯,溴,羟基和氰基)的偶合伴侣也适用于已开发的反应.合成的α-(2 / 4-硝基芳基)苯乙酰胺已通过新型途径转化为生物学上重要的苯并呋喃,黄嘌呤,二芳基吲哚和不对称二苯甲酮,而无需使用过渡金属.总的来说,已经设计了一种经济但有效的策略来获得不对称的二芳基乙酰胺,并可能将其进一步加工成多种生物学上重要的杂环.机械理解表明反应通过亲核加成一苯基乙酰胺负碳离子,这是在存在产生的前进叔丁醇的基础上,向第或邻位(如果对硝基苯的是取代的)位置.由dmso的碱性溶液或大气中的氧气氧化形成的α-(4-硝基环己-2,4-二烯-1-基)苯基乙酰胺阴离子中间体导致所需的sp
Doi:10.1021/acs.Joc.6B01771

专利信息

专利号:WO-0027627-A1
优先权日:1998-11-12
标题 :Aryloxime linkers in the solid-phase synthesis of 3-aminobenzisoxazoles
发明人：WILEY MICHAEL ROBERT; LEPORE SALVATORE DONATO
权利人:LILLY CO ELI; WILEY MICHAEL ROBERT; LEPORE SALVATORE DONATO
摘要:In its first aspect, the invention is directed to a solid support mediated method for the synthesis of diverse polycyclic heterocycles according to general formula (V). A second aspect of the invention is directed to a solid support bound intermediate compound that optionally can be derivatized before a cyclization and displacement procedure provides a product. The intermediate is preferably stable to a wide range of chemical conditions thus allowing, if desired, for the chemical derivatization of the intermediate. A third aspect of the invention is directed to a library of polycyclic heterocycle compounds where said library contains a plurality of diverse library compounds of general formula (V). A fourth aspect of the invention is directed to a method for the synthesis of a library of diverse polycyclic heterocycles by the general method described. A fifth aspect of the invention is directed to an assay kit for the identification of lead compounds of the library described therein.

专利号:US-11078465-B2
优先权日:2018-02-12
标题:Alcohol dehydrogenase mutant and application thereof in synthesis of diaryl chiral alcohols
发明人：NI YE; WANG YUE; DAI WEI; XU GUOCHAO; ZHOU JIEYU
权利人:UNIV JIANGNAN
摘要:The present disclosure discloses an alcohol dehydrogenase mutant and application thereof in synthesis of diaryl chiral alcohols, and belongs to the technical field of bioengineering. The alcohol dehydrogenase mutant of the present disclosure has excellent catalytic activity and stereoselectivity, and may efficiently catalyze the preparation of a series of chiral diaryl alcohols in R- and S-configurations. By coupling alcohol dehydrogenase of the present disclosure to glucose dehydrogenase or formate dehydrogenase, the synthesis of chiral diaryl alcohol intermediates of various antihistamines may be achieved. Compared with the prior art, a method for preparing diaryl chiral alcohols through asymmetric catalytic reduction using the alcohol dehydrogenase of the present disclosure has the advantages of simple and convenient operation, high substrate concentration, complete reaction and high product purity, and has great industrial application prospects.

专利号:US-2008221303-A1
优先权日:2004-02-18
标 题:Method for the Preparation of Peptide-Oligonucleotide Conjugates
发明人：KATZHENDLER JEHOSHUA; KLAUZNER YAKIR; BEYLIS IRENA; MIZHIRITSKII MICHAEL; SHPERNAT YAACOV; ASHKENAZI BORIS; FRIDLAND DMITRI
权利人:KATZHENDLER JEHOSHUA; KLAUZNER YAKIR; BEYLIS IRENA; MIZHIRITSKII MICHAEL; SHPERNAT YAACOV; ASHKENAZI BORIS; FRIDLAND DMITRI
摘要:The present invention relates to the synthesis of peptide-oligonucleotide conjugates (POC). More specifically, the invention relates to a novel method for the preparation of peptide-oligonucleotide conjugates, which can be conducted under mild conditions on solid support, can be performed manually or by a synthesizer, can be used to synthesize alternating sequences of peptides and oligonucleotides, and is applicable to the synthesis of a wide variety of peptide-oligonucleotide conjugates constructed from alternate peptide and oligonucleotide blocks.

专利号:US-2004110228-A1
优先权日:2002-04-01
标 题:Combinatorial organic synthesis of unique biologically active compounds
发明人：MCALPINE SHELLI R; TAYLOR RACHEL E; BOLLA MEGAN L; SEGALL ANCA M
摘要:The invention provides a method for making a combinatorial library of cyclic compounds, such as Holliday junction-trapping compounds, comprising the steps of (a) obtaining a plurality of trimers according to the generic structure X 1- X 2- X 3 , wherein X 1 , X 2 and X 3 can be independently any naturally or nonnaturally occurring amino acids or peptidomimetics thereof; (b) optionally coupling a spacer S to the trimer at either end; (c) cyclizing two trimers or trimer-spacer conjugates in a head-to-tail orientation; thereby obtaining a combinatorial library of compounds, wherein the library does not include an unmodifed or naturally occurring Holliday Junction-trapping compounds. The invention additionally provides methods macrocyclic compounds that are synergimycin derivatives.

专利号:US-5783577-A
优先权日:1995-09-15
标题 :Synthesis of quinazolinone libraries and derivatives thereof
发明人：HOUGHTEN RICHARD A; OSTRESH JOHN M
权利人:TREGA BIOSCIENCES INC
摘要:The present invention provides synthetic combinatorial libraries of organic compounds based on the quinazolinone ring.

专利号:WO-9710221-A1
优先权日:1995-09-15
标 题:Synthesis of quinazolinone libraries
发明人：HOUGHTEN RICHARD A; OSTRESH JOHN M
权利人:TORREY PINES INST
摘要:The present invention provides synthetic combinatorial libraries of organic compounds based on the quinazolinone ring.