4-Methoxy-2-Methylcyclohexa-2,5-Dien-1-One置于甘氨酸乙酯盐酸盐,三乙胺体系中,用 甲醇,水 用作溶剂,化学反应生成2-甲基-4-甲氧基苯胺 参考文献:由苯酚直接合成苯胺和亚硝基苯† 标题:由苯酚直接合成苯胺和亚硝基苯† 摘要:已经使用ipso-氧化性芳族取代(i S O Ar)方法开发了一种从苯酚一锅合成苯胺和亚硝基苯的方法.在温和且不含金属的条件下,可以以高收率获得产品.还研究了离去基团对通过混合的醌酮单缩酮进行的反应的影响,并建立了预测模型. Doi:10.1039/c6Ob00073H
专利信息
专利号:WO-2017063910-A1 优先权日:2015-10-16 标题:Agonists of the chemokine receptor cxcr3 发明人:TSCHAMMER NUSKA; MILANOS LAMPROS; BROX REGINE 权利人:Friedrich-Alexander-Universität Erlangen-Nürnberg 摘要:The present invention relates to agonists of the chemokine receptor CXCR3, methods of their synthesis and uses thereof.
专利号:US-6417195-B1 优先权日:1999-02-22 标题 :Isoquinoline derivatives and isoquinoline combinatorial libraries 发明人:LEBL MICHAL 权利人:LION BIOSCIENCE AG 摘要:The present invention provides the synthesis of heterocyclic compounds based on the isoquinoline ring. More specifically, the invention provides novel isoquinoline derivatives as well as novel libraries comprised of such compounds.
专利号:US-5874443-A 优先权日:1995-10-19 标 题:Isoquinoline derivatives and isoquinoline combinatorial libraries 发明人:KIELY JOHN S; GRIFFITH MICHAEL C 权利人:TREGA BIOSCIENCES INC 摘要:The present invention provides the synthesis of heterocyclic compounds based on the isoquinoline ring. More specifically, the invention provides novel isoquinolines as well as novel libraries comprised of many such compounds, and methods of synthesizing the libraries.
专利号:CN-108218730-A 优先权日:2018-02-13 标 题:A method for the copper-catalyzed synthesis of 2-methyl-4-methoxydiphenylamine with recyclable ligand
专利号:WO-0050406-A1 优先权日:1999-02-22 标 题 :Isoquinoline derivatives and isoquinoline combinatorial libraries 发明人:LEBL MICHAEL 权利人:TREGA BIOSCIENCES INC 摘要:The present invention provides the synthesis of heterocyclic compounds based on the isoquinoline ring. More specifically, the invention provides novel isoquinoline derivatives as well as novel libraries comprised of such compouds.
专利号:US-2023104311-A1 优先权日:2020-02-17 标题:Novel 6-substituted 7-deazapurines and corresponding nucleosides as medicaments 发明人:HERDEWIJN PIET; GROAZ ELISABETTA; QINGFENG LI 权利人:UNIV LEUVEN KATH 摘要:The present invention relates to the synthesis of 6-substituted 7-deazapurines and their corresponding nucleosides by coupling aryl or alkyl Grignard reagents with halogenated purine nucleosides in the presence of iron or an iron/copper mixture such as Fe(acac)3/CuI. The present invention also relates to pharmaceutical compositions comprising said compounds and the use of said pharmaceutical compositions to treat or prevent viral infections.
参考文献:10.1107/s1600536811015960 摘要:Arslan H, Algul O, Zirek S, Tari O, Demircan A, Hardcastle KI. 2-(4-Meth-oxy-2-methyl-anilino)-1,2-diphenyl-ethanone. Acta Crystallogr Sect E Struct Rep Online. 2011 Jun 01;67(Pt 6):o1303.