CAS: 914913-88-5; 8-(1-Hydroxyethyl)-2-Methoxy-3-((4-Methoxybenzyl)Oxy)-6H-Benzo[c]Chromen-6-One
该化合物是一种化学化合物,主要用作各种应用,特别是聚合物和涂层领域的添加剂,其特点是能够提高材料的性能,提供诸如提高热稳定性,紫外线抗药性和总体耐久性等特性;该物质经常用于配方,以提高聚合物的加工特性,使之适合塑料,粘合剂和密封剂;此外,Palomid 529可能与其他各种材料的挥发性低,而且非常相容性强,有助于其作为稳定剂或修饰剂的有效性;其特定化学结构和功能组在决定其与其他化合物的相互作用方面发挥着关键作用,影响其所含产品的最后特性;与任何化学物质一样,应参考安全数据表,以确保在工业环境中安全应用的处理和使用准则.
- 英文名称8-(1-Hydroxyethyl)-2-Methoxy-3-((4-Methoxybenzyl)Oxy)-6H-Benzo[c]Chromen-6-One
- 中文名称8-(1-羟基乙基)-2-甲氧基-3-[(4-甲氧基苯基)甲氧基]-6H-二苯并[B,D]吡喃-6-酮
- IUPAC名称8-(1-hydroxyethyl)-2-methoxy-3-((4-methoxybenzyl)oxy)-6H-benzo[c]chromen-6-one
- CAS编号914913-88-5
- MFCD编号:MFCD18633224
- EINECS号:806-313-6
- FDA UNII编号:XV9409EWG4
- 分子式:C24H22O6分子量:406.43
- 产品CID: 1951456
- 产品分类生物化工 → 抑制剂 → PI3K/Akt/mTOR抑制剂(PI3K/Akt/mTOR)
物理性质
- 熔点No Data Available
- 沸点614.0±55.0 °C at 760 mmHg
- 闪点213.4±25.0 °C
- 密度1.3±0.1 g/cm3
- pKa:11.79±0.20(预测)
- PSA:78.13
- LogP:4.84
- 折射率1.618
- 蒸汽压0.0±1.9 mmHg at 25°C
- 溶解性DMSO: Soluble10mg/mL, Clear
- 外观形态白色至米色粉末
- 储存条件-20°C
- 产品应用该化合物是一个新的非类小分子小型分子抑制剂,针对的是MTORC1 和MTORC2 复合体;它抑制内皮细胞扩散并诱发多孔中毒;抑制VEGF-和BFGF介介介的内分泌细胞扩散(分别是IC50=20纳米M和30纳米M);减少VEF-A驱动的PAKTS473,PGSK3ΒS9和PS6的磷酸性;在NCI-60肺癌细胞系列中表现出强大的抗生化活性活动(GI50 < 35微M);以依赖浓度的方式加强前列癌PC-3细胞的辐射诱发抗生抗生效应;抑制辐射诱导PAKT-AKAT激活并降低PC-3电池中的BCL-2/BAX比率;抑制ID-1和VEGBFF,以及降低辐射诱变MP-2和MMP-9;剂量驱动的AGVI-G-GA-GVA-M-M1-9;
MSDS等安全信息
欧盟法规
C&L通报上下游产品
4-methoxy-phenol 24H20O6C24H20O6 2-(4-methoxyphenoxy)pyridine合成工艺路线路线简述
- 2746-25-0 + 2242430-83-5 = 914913-88-5
反应条件:1.1 Reagents: Methyl Triflate Solvents: Toluene; 2 H,100 °C; 100 °C -> Rt1.2 Reagents: Sodium Solvents: Methanol; 30 Min,80 °C; 80 °C -> Rt1.3 Reagents: Hydrochloric Acid Solvents: Water; 30 Min,Ph 1,Rt1.4 Reagents: Potassium Carbonate Solvents: Dimethylformamide; 12 H,80 °C2.1 Reagents: Sodium Borohydride Solvents: Methanol,Dichloromethane; 20 Min,0 °C; 0 °C -> Rt; 2 H,Rt
标题:Experimental And Theoretical Studies On Ru(Ii)-Catalyzed Oxidative C-H/c-H Coupling Of Phenols With Aromatic Amides Using Air As Oxidant: Scope,Synthetic Applications,And Mechanistic Insights
作者:Zhang,Luoqiang; Et Al
参考文献:Acs Catalysis 日期:2018 卷标:8(9) 页码:8324-8335]
2746-25-0 + 524713-48-2 = 914913-88-5
反应条件:1.1 Reagents: Potassium Carbonate Solvents: Dimethylformamide; 12 H,80 °C2.1 Reagents: Sodium Borohydride Solvents: Methanol,Dichloromethane; 20 Min,0 °C; 0 °C -> Rt; 2 H,Rt
标题:Experimental And Theoretical Studies On Ru(Ii)-Catalyzed Oxidative C-H/c-H Coupling Of Phenols With Aromatic Amides Using Air As Oxidant: Scope,Synthetic Applications,And Mechanistic Insights
作者:Zhang,Luoqiang; Et Al
参考文献:Acs Catalysis 日期:2018 卷标:8(9) 页码:8324-8335]
2242430-83-5 = 914913-88-5
反应条件:1.1 Reagents: Methyl Triflate Solvents: Toluene; 2 H,100 °C; 100 °C -> Rt1.2 Reagents: Sodium Solvents: Methanol; 30 Min,80 °C; 80 °C -> Rt1.3 Reagents: Hydrochloric Acid Solvents: Water; 30 Min,Ph 1,Rt2.1 Reagents: Potassium Carbonate Solvents: Dimethylformamide; 12 H,80 °C3.1 Reagents: Sodium Borohydride Solvents: Methanol,Dichloromethane; 20 Min,0 °C; 0 °C -> Rt; 2 H,Rt
标题:Experimental And Theoretical Studies On Ru(Ii)-Catalyzed Oxidative C-H/c-H Coupling Of Phenols With Aromatic Amides Using Air As Oxidant: Scope,Synthetic Applications,And Mechanistic Insights
作者:Zhang,Luoqiang; Et Al
参考文献:Acs Catalysis 日期:2018 卷标:8(9) 页码:8324-8335]
914913-86-3 = 914913-88-5
反应条件:1.1 Reagents: Sodium Borohydride Solvents: Methanol,Dichloromethane; 20 Min,0 °C; 0 °C -> Rt; 2 H,Rt
标题:Experimental And Theoretical Studies On Ru(Ii)-Catalyzed Oxidative C-H/c-H Coupling Of Phenols With Aromatic Amides Using Air As Oxidant: Scope,Synthetic Applications,And Mechanistic Insights
作者:Zhang,Luoqiang; Et Al
参考文献:Acs Catalysis 日期:2018 卷标:8(9) 页码:8324-8335]
105-13-5 + 2242430-82-4 = 914913-88-5
反应条件:1.1 Reagents: Cesium Carbonate Catalysts: 3,4,7,8-Tetramethyl-1,10-Phenanthroline,Cuprous Iodide Solvents: Toluene; 24 H,110 °C2.1 Reagents: Methyl Triflate Solvents: Toluene; 2 H,100 °C; 100 °C -> Rt2.2 Reagents: Sodium Solvents: Methanol; 30 Min,80 °C; 80 °C -> Rt2.3 Reagents: Hydrochloric Acid Solvents: Water; 30 Min,Ph 1,Rt2.4 Reagents: Potassium Carbonate Solvents: Dimethylformamide; 12 H,80 °C3.1 Reagents: Sodium Borohydride Solvents: Methanol,Dichloromethane; 20 Min,0 °C; 0 °C -> Rt; 2 H,Rt
标题:Experimental And Theoretical Studies On Ru(Ii)-Catalyzed Oxidative C-H/c-H Coupling Of Phenols With Aromatic Amides Using Air As Oxidant: Scope,Synthetic Applications,And Mechanistic Insights
作者:Zhang,Luoqiang; Et Al
参考文献:Acs Catalysis 日期:2018 卷标:8(9) 页码:8324-8335]
2150631-37-9 + 2242430-97-1 = 914913-88-5
反应条件:1.1 Reagents: Cupric Acetate,Oxygen Catalysts: Acetic Acid,Zinc Triflate,Ruthenium(2+),Tris(Acetonitrile)[(1,2,3,4,5,6-η)-1-Methyl-4-(1-Methylethyl)Benz... Solvents: Toluene; 15 H,140 °C2.1 Reagents: Cesium Carbonate Catalysts: 3,4,7,8-Tetramethyl-1,10-Phenanthroline,Cuprous Iodide Solvents: Toluene; 24 H,110 °C3.1 Reagents: Methyl Triflate Solvents: Toluene; 2 H,100 °C; 100 °C -> Rt3.2 Reagents: Sodium Solvents: Methanol; 30 Min,80 °C; 80 °C -> Rt3.3 Reagents: Hydrochloric Acid Solvents: Water; 30 Min,Ph 1,Rt3.4 Reagents: Potassium Carbonate Solvents: Dimethylformamide; 12 H,80 °C4.1 Reagents: Sodium Borohydride Solvents: Methanol,Dichloromethane; 20 Min,0 °C; 0 °C -> Rt; 2 H,Rt
标题:Experimental And Theoretical Studies On Ru(Ii)-Catalyzed Oxidative C-H/c-H Coupling Of Phenols With Aromatic Amides Using Air As Oxidant: Scope,Synthetic Applications,And Mechanistic Insights
作者:Zhang,Luoqiang; Et Al
参考文献:Acs Catalysis 日期:2018 卷标:8(9) 页码:8324-8335]
78646-39-6 = 914913-88-5
反应条件:1.1 Reagents: Acetic Acid,P-Toluenesulfonic Acid,N-Iodosuccinimide Solvents: Dichloromethane; 12 H,Rt2.1 Reagents: Cupric Acetate,Oxygen Catalysts: Acetic Acid,Zinc Triflate,Ruthenium(2+),Tris(Acetonitrile)[(1,2,3,4,5,6-η)-1-Methyl-4-(1-Methylethyl)Benz... Solvents: Toluene; 15 H,140 °C3.1 Reagents: Cesium Carbonate Catalysts: 3,4,7,8-Tetramethyl-1,10-Phenanthroline,Cuprous Iodide Solvents: Toluene; 24 H,110 °C4.1 Reagents: Methyl Triflate Solvents: Toluene; 2 H,100 °C; 100 °C -> Rt4.2 Reagents: Sodium Solvents: Methanol; 30 Min,80 °C; 80 °C -> Rt4.3 Reagents: Hydrochloric Acid Solvents: Water; 30 Min,Ph 1,Rt4.4 Reagents: Potassium Carbonate Solvents: Dimethylformamide; 12 H,80 °C5.1 Reagents: Sodium Borohydride Solvents: Methanol,Dichloromethane; 20 Min,0 °C; 0 °C -> Rt; 2 H,Rt
标题:Experimental And Theoretical Studies On Ru(Ii)-Catalyzed Oxidative C-H/c-H Coupling Of Phenols With Aromatic Amides Using Air As Oxidant: Scope,Synthetic Applications,And Mechanistic Insights
作者:Zhang,Luoqiang; Et Al
参考文献:Acs Catalysis 日期:2018 卷标:8(9) 页码:8324-8335]
150-76-5 + 109-04-6 = 914913-88-5
反应条件:1.1 Reagents: Picolinic Acid,Tripotassium Phosphate Catalysts: Cuprous Iodide Solvents: Dimethyl Sulfoxide; 24 H,90 °C2.1 Reagents: Acetic Acid,P-Toluenesulfonic Acid,N-Iodosuccinimide Solvents: Dichloromethane; 12 H,Rt3.1 Reagents: Cupric Acetate,Oxygen Catalysts: Acetic Acid,Zinc Triflate,Ruthenium(2+),Tris(Acetonitrile)[(1,2,3,4,5,6-η)-1-Methyl-4-(1-Methylethyl)Benz... Solvents: Toluene; 15 H,140 °C4.1 Reagents: Cesium Carbonate Catalysts: 3,4,7,8-Tetramethyl-1,10-Phenanthroline,Cuprous Iodide Solvents: Toluene; 24 H,110 °C5.1 Reagents: Methyl Triflate Solvents: Toluene; 2 H,100 °C; 100 °C -> Rt5.2 Reagents: Sodium Solvents: Methanol; 30 Min,80 °C; 80 °C -> Rt5.3 Reagents: Hydrochloric Acid Solvents: Water; 30 Min,Ph 1,Rt5.4 Reagents: Potassium Carbonate Solvents: Dimethylformamide; 12 H,80 °C6.1 Reagents: Sodium Borohydride Solvents: Methanol,Dichloromethane; 20 Min,0 °C; 0 °C -> Rt; 2 H,Rt
标题:Experimental And Theoretical Studies On Ru(Ii)-Catalyzed Oxidative C-H/c-H Coupling Of Phenols With Aromatic Amides Using Air As Oxidant: Scope,Synthetic Applications,And Mechanistic Insights
作者:Zhang,Luoqiang; Et Al
参考文献:Acs Catalysis 日期:2018 卷标:8(9) 页码:8324-8335
📜8-Acetyl-2-Methoxy-3-[(4-Methoxyphenyl)Methoxy]Benzo[c]Chromen-6-One置于sodium Tetrahydroborate体系中,用 甲醇,二氯甲烷 作为反应溶剂,化学反应 3.0H,反应生成 Palomid529,一种有效的mtorc1和mtorc2复合物的抑制剂
参考文献:空气作为氧化剂的ru(II)催化苯酚与芳酰胺的氧化c-h / C-h偶联反应的实验和理论研究:范围,合成应用和机理研究
标题:空气作为氧化剂的ru(II)催化苯酚与芳酰胺的氧化c-h / C-h偶联反应的实验和理论研究:范围,合成应用和机理研究
摘要:我们在本文中说明了借助zn(otf)2的ru(II)催化的酚与(杂)芳族酰胺的氧化邻位-C-H / C-H交叉偶联的双重螯合辅助策略.,可快速组装2'-羟基联苯-2-羧酸衍生物的丰富文库.该方案具有广泛的底物范围,优异的官能团耐受性,空气作为末端氧化剂,偶联剂的摩尔比低以及按比例放大的合成.特别是,该方法可以耐受更复杂的天然产物衍生物,从而为后期功能化提供了机会.该方案还被用作简明合成palomid 529的关键步骤,Palomod 529是一种正在开发的用于治疗胶质母细胞瘤和新血管性年龄相关性黄斑变性的药物.结合实验和理论方法,我们对决定反应过程的策略的基本问题有更多的了解.2-芳氧基吡啶的较强的配位能力和酰胺的空间位阻较小,这是交叉偶联相对于均相偶联的高化学选择性的关键.第一个c-h键活化步骤发生在酰胺底物上,随后在2-芳氧基吡啶上的c-h键活化反应参与速率确定的步骤.
DOI:10.1021/acscatal.8B02816
海关参考信息
- 2902600000-乙苯
2906210000-苄醇
2907210001-间苯二酚
2908199090-其他酚的卤化衍生物 - 💡 提示：海关信息按照顺序优先匹配，如需确认的海关信息，请参考相关资料。
- 详情请参考：📖 海关编码查询和海关进出口税则
专利信息
专利号:US-12391691-B2
优先权日:2018-11-16
标题:Synthesis of key intermediate of KRAS G12C inhibitor compound
发明人：PARSONS ANDREW THOMAS; COCHRAN BRIAN MCNEIL; POWAZINIK IV WILLIAM; CAPORINI MARC ANTHONY
权利人:AMGEN INC
摘要:The present invention relates to an improved, efficient, scalable process to prepare intermediate compounds, such as compound 5M, having the structure n nuseful for the synthesis of compounds that target KRAS G12C mutations, such as
专利号:US-2025206736-A1
优先权日:2019-11-14
标题 :Synthesis of kras g12c inhibitor compound
发明人：CORBETT MICHAEL THOMAS; CAILLE SEBASTIEN
权利人:AMGEN INC
摘要:The present disclosure relates to an improved, efficient, scalable process to prepare intermediate compounds, such as 2-isopropyl-4-methylpyridin-3-amine, useful for the synthesis of compounds, such as Compound 9, for the treatment of KRAS G12C mutated cancers.
专利号:US-2025289827-A1
优先权日:2022-12-02
标 题:Morphic forms of a mutant braf degrader and methods of manufacture thereof
发明人：YU ROBERT T; HE MINSHENG; SCHNADERBECK MATTHEW J; KREGER BRIDGET; POLLOCK ROY MACFARLANE; JIANG SIYI; LI MEIQI; CHEN BOLU; LU JIANNAN
权利人:C4 THERAPEUTICS INC
摘要:Advantageous isolated morphic forms of (3R)-3-[6-[2-cyano-3-[[ethyl(methyl)sulfamoyl]amino]-6-fluorophenoxy]-4-oxoquinazolin-3-yl]-8-[2-[1-[3-(2,4-dioxo-1,3-diazinan-1-yl)-5-fluoro-1-methylindazol-6-yl]-4-hydroxypiperidin-4-yl]acetyl]-1-oxa-8-azaspiro[4.5]decane (Compound 1), which is a mutant BRAF degrader, and methods to prepare Compound 1 morphic forms for therapeutic applications are provided in the invention. The invention also provides improved methods for the synthesis of Compound 1, new pharmaceutical compositions comprising Compound 1, and new uses of Compound 1.
专利号:US-10772971-B2
优先权日:2017-06-22
标 题:Methods of producing drug-carrying polymer scaffolds and protein-polymer-drug conjugates
发明人：GURIJALA VENU REDDY; BOLLU SATYANARAYAN REDDY; LEBLANC JACQUES; LOWINGER TIMOTHY B; MCGILLICUDDY DENNIS; YIN MAO; YURKOVETSKIY ALEKSANDR V
权利人:MERSANA THERAPEUTICS INC; MERSANA THERPEUTICS INC
摘要:The disclosure provides methods of synthesis of polymeric scaffolds, e.g., those useful for conjugating with a protein based recognition-molecule (PBRM) to form PBRM-polymer-drug conjugates, and PBRM-polymer-drug conjugates thereof. The methods according to the disclosure allow for large-scale preparation of polymeric scaffolds having a high purity. In some embodiments, the methods according to the disclosure also allow for the preparation of scaffolds and conjugates thereof in better yield than previously used methods for preparing same. Also disclosed are methods of purifying polymeric scaffolds.
专利号:US-2023192681-A1
优先权日:2019-11-14
标 题 :Improved synthesis of kras g12c inhibitor compound
专利号:US-11299491-B2
优先权日:2018-11-16
标 题:Synthesis of key intermediate of KRAS G12C inhibitor compound
供应商参考报价(招募中)
品牌试剂参考报价(招募中)
📌 第三方产品分析报告
主要参考文献
1: He TY, Tsai LH, Huang CC, Chou MC, Lee H. LKB1 Loss at Transcriptional Level Promotes Tumor Malignancy and Poor Patient Outcomes in Colorectal Cancer. Ann Surg Oncol. 2014 May 31. [Epub ahead of print] doi: 10.1002/pros.22804. Epub 2014 Apr 8. doi: 10.1007/s00417-013-2375-7. Epub 2013 May 21. doi: 10.1002/ijc.28126. Epub 2013 Apr 1. doi: 10.1016/j.ajpath.2012.08.006. Epub 2012 Sep 11. Erratum in: Am J Pathol. 2014 Apr;184(4):1253. Singh, Subir [added]. doi: 10.1016/j.jchromb.2011.10.028. Epub 2011 Oct 29. doi: 10.1530/ERC-11-0045. Print 2011 Aug. doi: 10.1038/onc.2010.603. Epub 2011 Jan 17.
9: Lewis GP, Chapin EA, Byun J, Luna G, Sherris D, Fisher SK. Muller cell reactivity and photoreceptor cell death are reduced after experimental retinal detachment using an inhibitor of the Akt/mTOR pathway. Invest Ophthalmol Vis Sci. 2009 Sep;50(9):4429-35. doi: 10.1167/iovs.09-3445. Epub 2009 Apr 15. doi: 10.1038/sj.bjc.6604938. Epub 2009 Feb 24.
11: Xue Q, Hopkins B, Perruzzi C, Udayakumar D, Sherris D, Benjamin LE. Palomid 529, a novel small-molecule drug, is a TORC1/TORC2 inhibitor that reduces tumor growth, tumor angiogenesis, and vascular permeability. Cancer Res. 2008 Nov 15;68(22):9551-7. doi: 10.1158/0008-5472.CAN-08-2058.
合成参考文献
参考文献:10.1245/s10434-014-3824-1
摘要:He TY, Tsai LH, Huang CC, Chou MC, Lee H. LKB1 loss at transcriptional level promotes tumor malignancy and poor patient outcomes in colorectal cancer. Ann Surg Oncol. 2014 Dec;21 Suppl 4():S703–10. doi: 10.1245/s10434-014-3824-1.
📝 需求与反馈
尽可能描述清楚需求与问题信息
