CAS: 89-68-9; 4-Chloro-2-Isopropyl-5-Methylphenol

该化合物是一种有机化合物,其特点是芳香结构,并含有氯原子和苯球环上的甲基组;它看起来无色可粉黄色,具有一种特质的气味;氯酚在有机溶剂中可溶,但在水中溶解性有限;它具有抗菌特性,在各种应用中有用,包括在药物和个人护理产品中作为防腐剂和防腐剂;该化合物还被用于其他化学品的合成和食品中的调味剂;氯酚的化学结构有助于其再活性,使其能够参与各种化学反应,包括替代和氧化;在处理该物质时,需要安全防范,因为它可能会对皮肤和眼睛产生刺激作用,并且应当保持适当的储存条件以防止降解;

结构式图片

物理性质

MSDS等安全信息

欧盟法规

ECHA物质C&L通报REACH预注册

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CAS号89-83-8 麝香草酚 | CAS号5411-11-0 (4-氯-2-异丙基-5-甲基... | CAS号859181-31-0 (4-chloro-3-met... | CAS号507-40-4 次氨酸叔丁基酯 | CAS号1128-28-5 4-氨基-2-异丙基-5-甲基苯酚 | CAS号59-50-7 4-氯-3-甲基苯酚 | CAS号187737-37-7 propene | CAS号75-29-6 2-氯丙烷 | CAS号108-20-3 异丙醚 | CAS号67-63-0 异丙醇 | CAS号490-91-5 百里醌 | CAS号89-83-8 麝香草酚 | CAS号303-21-9 Phenol,3-methyl... | CAS号72373-71-8 (2R,3R,4S,5R,6S... | CAS号36778-56-0 5-methyl-2-(1-m... | CAS号15686-33-6 双氯麝酚 | CAS号91147-76-1 (4-chloro-5-met... | CAS号46984-56-9 4-chloro-3-meth... | CAS号591-09-3 nitro acetate | CAS号6300-54-5 Phenol,4-chloro...

合成工艺路线路线简述

  • 89-83-8 = 89-68-9
    反应条件:1.1 Reagents: Hydrochloric Acid,Oxygen Catalysts: Cupric Chloride Solvents: Water; 10 Min,50 °C
    标题:Highly Selective Synthesis Of Chlorophenols Under Microwave Irradiation
    作者:Xiong,Yawen; Duan,Hongdong; Meng,Xia; Ding,Zhaoyun; Feng,Weichun
    参考文献:Journal Of Chemistry 日期:2016 卷标:2960414 页码:2960414/1-2960414/5]

    89-83-8 = 89-68-9
    反应条件:1.1 Reagents: Sulfuryl Chloride Solvents: Carbon Tetrachloride; 0 °C -> Rt; 45 Min,Rt1.2 Reagents: Water; Cooled
    标题:Identification And Structure-Activity Relationship Study Of Carvacrol Derivatives As Mycobacterium Tuberculosis Chorismate Mutase Inhibitors
    作者:Alokam,Reshma; Jeankumar,Variam Ullas; Sridevi,Jonnalagadda Padma; Matikonda,Siddharth Sai; Peddi,Santosh; Et Al
    参考文献:Journal Of Enzyme Inhibition And Medicinal Chemistry 日期:2014 卷标:29(4) 页码:547-554]

    89-83-8 = 89-68-9 + 7408-66-4
    反应条件:1.1 Reagents: Sodium Chloride,Hydrogen Peroxide Catalysts: Chloroperoxidase Solvents: Water; 40 Min,Ph 2.75,25 °C
    标题:Enzymatic Halogenation Of The Phenolic Monoterpenes Thymol And Carvacrol With Chloroperoxidase
    作者:Getrey,Laura; Krieg,Thomas; Hollmann,Frank; Schrader,Jens; Holtmann,Dirk
    参考文献:Green Chemistry 日期:2014 卷标:16(3) 页码:1104-1108]

    89-83-8 = 89-68-9
    反应条件:1.1 Reagents: Lithium Chloride,Oxygen Catalysts: Cupric Chloride Solvents: Acetic Acid; 6 H,80 °C
    标题:Semisynthetic Phenol Derivatives Obtained From Natural Phenols: Antimicrobial Activity And Molecular Properties
    作者:Pinheiro,Patricia Fontes; Menini,Luciana Alves Parreira; Bernardes,Patricia Campos; Saraiva,Sergio Henriques; Carneiro,Jose Walkimar Mesquita; Et Al
    参考文献:Journal Of Agricultural And Food Chemistry 日期:2018 卷标:66(1) 页码:323-330]

    5411-11-0 = 89-68-9
    反应条件:1.1 Reagents: Triethylamine,Phosphorazidic Acid,Diethyl Ester Solvents: Dimethylformamide,Toluene; 30 Min,Rt; 3 H,Reflux1.2 Reagents: Potassium Hydroxide Solvents: Glycerol,Ethanol,Water; 2 H,Reflux1.3 Reagents: Citric Acid Solvents: Water; Ph 5
    标题:High-Yielding Cleavage Of (Aryloxy) Acetates
    作者:Spurg,Anke; Waldvogel,Siegfried R.
    参考文献:European Journal Of Organic Chemistry 日期:2008 卷标:(2) 页码:337-342]

    = 89-68-9
    反应条件:1.1 Reagents: Triethylamine,Phosphorazidic Acid,Diethyl Ester Solvents: Dimethylformamide,Toluene; 30 Min,Rt; Rt -> Reflux; 3 H,Reflux1.2 Reagents: Potassium Hydroxide Solvents: Glycerol,Ethanol,Water; 2 H,Reflux1.3 Reagents: Citric Acid Solvents: Water; Ph 5
    标题:Reliable And General Method For The Cleavage Of α-Arylheteroatom-Substituted Carboxylic Acids
    作者:Spurg,Anke; Waldvogel,Siegfried R.
    参考文献:Synlett 日期:2007 卷标:(19) 页码:3042-3044]

    89-83-8 = 89-68-9
    反应条件:1.1 Reagents: Lithium Chloride,Oxygen Catalysts: Cupric Chloride Solvents: Acetic Acid; 3.5 H,1 Atm,80 °C
    标题:Aerobic Oxychlorination Of Phenols Catalyzed By Copper(Ii) Chloride
    作者:Menini,Luciano; Gusevskaya,Elena V.
    参考文献:Applied Catalysis 日期:2006 卷标:309(1) 页码:122-128]

    89-83-8 = 89-68-9
    反应条件:1.1 Reagents: Lithium Chloride,Oxygen Solvents: Acetic Acid; 4 H,80 °C
    标题:Novel Highly Selective Catalytic Oxychlorination Of Phenols
    作者:Menini,Luciano; Gusevskaya,Elena V.
    参考文献:Chemical Communications (Cambridge 日期:2006 卷标:(2) 页码:209-211]

    89-83-8 = 89-68-9
    反应条件:1.1 Reagents: Chlorosuccinimide Solvents: Carbon Tetrachloride; 60 - 70 °C
    标题:Synthesis Of Halogenated Derivatives Of Thymol And Their Antimicrobial Activities
    作者:Kaur,Ranjeet; Darokar,Mahendra P.; Chattopadhyay,Sunil Kumar; Krishna,Vinay; Ahmad,Ateeque
    参考文献:Medicinal Chemistry Research 日期:2014 卷标:23(5) 页码:2212-2217]

    89-83-8 = 89-68-9 + 7408-66-4 [标题:Reaction Conditions
    标题:Product Class: Monohydric Phenols And Corresponding Phenolates - Synthesis With Retention Of The Functional Group
    作者:Gonzalez-Bello,C.; Castedo,L.
    参考文献:Science Of Synthesis 日期:2007 卷标:31 页码:331-336
📜(4-氯-3-甲基-苯基)-异丙基醚置于硫酸,溶剂黄146体系中,化学反应生成 4-氯-2-异丙基-5-甲基苯酚
参考文献:The Synthesis Of Thymol,Chlorothymol And Homologs Of Thymol By The Intramolecular Rearrangement Of Meta-Cresyl Ethers
标题:The Synthesis Of Thymol,Chlorothymol And Homologs Of Thymol By The Intramolecular Rearrangement Of Meta-Cresyl Ethers
摘要:
DOI:10.1021/ja01342A029

海关参考信息

专利信息


专利号:US-2004110228-A1
优先权日:2002-04-01
标 题:Combinatorial organic synthesis of unique biologically active compounds
发明人：MCALPINE SHELLI R; TAYLOR RACHEL E; BOLLA MEGAN L; SEGALL ANCA M
摘要:The invention provides a method for making a combinatorial library of cyclic compounds, such as Holliday junction-trapping compounds, comprising the steps of (a) obtaining a plurality of trimers according to the generic structure X 1- X 2- X 3 , wherein X 1 , X 2 and X 3 can be independently any naturally or nonnaturally occurring amino acids or peptidomimetics thereof; (b) optionally coupling a spacer S to the trimer at either end; (c) cyclizing two trimers or trimer-spacer conjugates in a head-to-tail orientation; thereby obtaining a combinatorial library of compounds, wherein the library does not include an unmodifed or naturally occurring Holliday Junction-trapping compounds. The invention additionally provides methods macrocyclic compounds that are synergimycin derivatives.

专利号:US-9314021-B2
优先权日:2004-11-03
标题 :Formulations containing insect repellent compounds
发明人：SCIALDONE MARK A
权利人:DU PONT
摘要:Dihydronepetalactone, a minor natural constituent of the essential oil of catmints ( Nepeta spp.) such as Nepeta cataria , has been identified as an effective insect repellent compound. Synthesis of dihydronepetalactone may be achieved by hydrogenation of nepetalactone, the major constituent of catmint essential oils. This compound, and compositions thereof, which also has fragrance properties, may be used commercially for its insect repellent properties.

专利号:US-9125843-B2
优先权日:2013-10-03
标 题 :Methods and compositions for improving the appearance of skin
发明人：PERNODET NADINE A; COLLINS DONALD F
权利人:PERNODET NADINE A; COLLINS DONALD F; ELC MAN LLC
摘要:A method for stimulating collagen synthesis in aging skin cells in need of treatment by topically applying a composition comprising at least one extract from Laminaria genus, at least one extract from the Narcissus genus, and at least one peptide that stimulates sirtuin 6 activity in the form of a peptide or a yeast extract where the peptide is component of the extract; and a treatment composition comprising at least one extract from Laminaria genus, at least one extract from the Narcissus genus; and at least one peptide that stimulates sirtuin 6 activity.

专利号:US-9750682-B2
优先权日:2015-07-30
标题:Methods and compositions for improving the appearance of skin
发明人：PERNODET NADINE; COLLINS DONALD
权利人:ELC MAN LLC; ELC MAN LLC
摘要:A method for stimulating collagen synthesis in aging skin cells in need of treatment by stimulating SIRT1, SIRT3, and SIRT6 and a method for preparing a topical composition for stimulating SIRT1, SIRT3, and SIRT6 in skin cells.

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主要参考文献


1: Delgado-Marín L, Sánchez-Borzone M, García DA. Neuroprotective effects of gabaergic phenols correlated with their pharmacological and antioxidant properties. Life Sci. 2017 Apr 15;175:11-15. doi: 10.1016/j.lfs.2017.03.005. Epub 2017 Mar 10. doi: 10.1007/s12013-013-9537-4. doi: 10.1016/j.jpba.2008.12.040. Epub 2009 Jan 8.
5: Andersen A. Final report on the safety assessment of sodium p-chloro-m-cresol, p-chloro-m-cresol, chlorothymol, mixed cresols, m-cresol, o-cresol, p-cresol, isopropyl cresols, thymol, o-cymen-5-ol, and carvacrol. Int J Toxicol. 2006;25 Suppl
1:29-127.

合成参考文献


摘要:Littke, A., Science of Synthesis: Cross Coupling and Heck-Type Reactions, (2012) 1, 210.
摘要:Lumb, J.-P.; Esguerra, K. V. N., Science of Synthesis: Catalytic Oxidation in Organic Synthesis, (2017) 1, 626.
摘要:S13 | EUCOSMETICS | Combined Inventory of Ingredients Employed in Cosmetic Products (2000) and Revised Inventory (2006) | DOI:10.5281/zenodo.2624118
摘要:International Journal of Toxicology 25(Suppl. 1):29-127, 2006
摘要:P. Demerseman, R. Reynaud, A. Cheutin, R. Royer and P. Rumpf, Bull. Soc. Chim. Fr. 1960, 1508.
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