CAS: 87562-76-3; Kelampayoside A

该化合物是天然化合物,主要从植物物种Kelampayan(Shorea spp.)中提取,主要来自植物物种Kelampayan(Shorea spp.),主要特征是复杂的甘醇结构,通常包括一种与一种或多种糖糖糖粒相连的类固醇类甘油.该化合物展示了一系列生物活动,包括抗炎,抗氧化剂和潜在的抗癌特性,从而引起对药理学研究的兴趣.Kelampayoside A是极地溶剂的溶液,对沙潘因很常见,其结构有助于其表面活性特性.多种水氧基组的存在加强了其反应和与生物膜的相互作用.此外,其独特的结构特征可能会影响其在治疗应用中的生物利用率和功效.随着研究的继续进行,正在探索其药理学潜力和作用机制的全部范围,突出天然产品在......

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3,4,5-trimethoxyphenyl 6-O-(5-O-benzyl-β-D-erythro-apiofuranosyl)-β-D-glucopyranoside 3,4,5-trimethoxyphenol ethyl 2,3,4-tri-O-benzoyl-1-thio-β-D-glucopyranoside 3,4,5-trimethoxyphenyl 6-O-(2,3-di-O-acetyl-5-O-benzyl-β-D-erythro-apiofuranosyl)-2,3,4-tri-O-benzoyl-β-D-glucopyranoside

合成工艺路线路线简述

    📜3,4,5-三甲氧基苯酚置于palladium On Activated Charcoal 三氟化硼乙醚,氢气,Sodium Methylate体系中,用 四氢呋喃,甲醇,二氯甲烷,异丙醇 作为反应溶剂,化学反应生成 Kelampayoside A; 3,4,5-三甲氧基苯基 6-O-D-芹糖-Beta-D-呋喃糖基-Beta-D-葡萄糖苷
    参考文献:Synthesis Of 3,4,5-Trimethoxyphenyl 5''-O-Caffeoyl-β-D-Erythro-Apiofuranosyl-(1->6)-β-D-Glucopyranoside: Kelampayoside B
    标题:Synthesis Of 3,4,5-Trimethoxyphenyl 5''-O-Caffeoyl-β-D-Erythro-Apiofuranosyl-(1->6)-β-D-Glucopyranoside: Kelampayoside B
    摘要:Chemoselective Nis/ Cat. Tfoh-Mediated Glycosylation Of Ethyl 2,3,4-Tri-O-Benzoyl-1-Thio-Beta-D-Glucopyranoside (4) With Ethyl 2,3-Di-O-Acetyl-5-O-Benzyl-1-Thio-Alpha/beta-D-Erythro-Apiofuranoside (3) Gave Dimer 5 In An Excellent Yield. Bf3Et2O-Catalysed Condensation Of The Alpha-Trichloroacetimidate 18,Accessible In Two Steps From 5,With 3,4,5-Trimethoxyphenol Gave Beta-Linked Derivative 19 Which Could Be Transformed In Five Steps Into The Title Compound. (C) 1998 Elsevier Science Ltd. All Rights Reserved.
    DOI:10.1016/s0040-4039(98)00673-X

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    主要参考文献

    参考标题:An Expeditious Route To The Synthesis Of Kelampayosides A And B
    作者:Howard I. Duynstee,Martijn C. De Koning,Gijs A. Van Der Marel,Jacques H. Van Boom |发布日期:1999.8
    摘要:Chemoselective Nis/ Cat. Tfoh-Mediated Glycosylation Of Ethyl2,3,4-Tri-O-Benzoyl-1-Thio-β-D-Glucopyranoside (13) With Ethyl2,3-Di-O-Acetyl-5-O-Benzyl-1-Thio-αβ-D-Erythro-Apiofuranoside (4A) Gave Dimer14 In An Excellent Yield. Bf3.et2O-Catalysed Condensation Of The α-Trichloroacetimidate31, Accessible In Two Steps From14, With 3,4,5-Trimethoxyphenol Gave β-Linked Derivative32 Followed By Deprotection

    合成参考文献


    参考文献:10.1021/np010042g
    摘要:Zhang Z, ElSohly HN, Jacob MR, Pasco DS, Walker LA, Clark AM. New Indole Alkaloids from the Bark of Nauclea orientalis. J. Nat. Prod. 2001 Jul 13;64(8):1001–5. doi: 10.1021/np010042g.
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