CAS: 80102-27-8; Boc-D-Phe(4-Me)-Oh

该化合物是一种手性非天然氨基酸衍生物,其成分为乙氧基碳基(Boc)保护组和p-tolyl侧链.该化合物因其在标准结合条件下具有高对等纯度和稳定性,广泛用于peptide合成和制药研究.该化合物在标准结合条件下促进选择性脱保,同时保持与固相聚聚聚(SPPS)协议的兼容性.其芳香聚氨酯会增强疏水性,使其对改变聚二丁基苯基特性或研究结构-活性关系很有价值.该产品具有一贯质量,低种族化风险和复杂有机转化可靠性能的特点.该产品是发展生物活性聚苯酯和小型分子治疗的关键中间体.

英文名称Boc-D-Phe(4-Me)-Oh
中文名称BOC-D-4-甲基苯丙氨酸
IUPAC名称3-(4-methylphenyl)-2-[(2-methylpropan-2-yl)oxycarbonylamino]propanoic acid
其它别名Boc-D-4-甲基苯丙氨酸, >=98%; Boc-D-4-Methylphenylalanine
CAS编号80102-27-8
MFCD编号:MFCD01317726
EINECS号:802-266-0
分子式:C15H21NO4
分子量:279.336
产品CID: 1794988
产品分类有机原料→分子砌块→芳环类化合物→苯类化合物

相似结构搜索
InChIKey: JYRWNPUFECDJCX-GFCCVEGCSA-N
1S/C15H21NO4/c1-10-5-7-11(8-6-10)9-12(13(17)18)16-14(19)20-15(2,3)4/h5-8,12H,9H2,1-4H3,(H,16,19)(H,17,18)/t12-/m1/s1…
计算化学: 氢键受体数3.0氢键供体数2.0可旋转键数4.0

MSDS等安全信息

GHS符号GHS07
警示词Warning
危险描述H302-H315-H319-H335
防范说明P261-P280-P302+P352
危险等级IRRITANT
危险品标志Xi
安全声明H303+H313+H333
WGK Germany3

上下游产品

16H23NO4C16H23NO4tert-butyl [(2R)-1-{4-[(4aS,8aR)-4-(3,4-dimethoxyphenyl)-1-oxo-4a,5,6,7,8,8a-hexahydrophthalazin-2(1H)-yl]piperidin-1-yl}-3-(4-methylphenyl)-1-oxopropan-2-yl]carbamate 4-[5-(cyclopropylmethoxy)-1,3-benzodioxol-4-yl]-N-[(2R)-1-{4-[(4aS,8aR)-4-(3,4-dimethoxyphenyl)-1-oxo-4a,5,6,7,8,8a-hexahydrophthalazin-2(1H)-yl]piperidin-1-yl}-3-(4-methyl phenyl)-1-oxopropan-2-yl]-6-methyl-5H-pyrrolo[3,2-d]pyrimidine-7-carboxamide 4-[5-(cyclopropylmethoxy)-1,3-benzodioxol-4-yl]-N-[(2R)-1-{4-[(4aS,8aR)-4-(3,4-dimethoxyphenyl)-1-oxo-4a,5,6,7,8,8a-hexahydrophthalazin-2(1H)-yl]piperidin-1-yl}-3-(4-methylphenyl)-1-oxopropan-2-yl]-5H-pyrrolo[3,2-d]pyrimidine-7-carboxamide (R)-methyl 2-amino-3-(4-tolyl)propanoate

合成工艺路线路线简述

178413-84-8 = 80102-27-8
反应条件:1.1 Reagents: Lithium Hydroxide Solvents: Methanol,Tetrahydrofuran,Water; 6 H,0 °C
标题:Discovery Of Pyrrolopyrimidine Inhibitors Of Akt
作者:Blake,James F.; Et Al
参考文献:Bioorganic & Medicinal Chemistry Letters 日期:2010 卷标:20(19) 页码:5607-5612]

= 80102-27-8
反应条件:1.1 Reagents: Hydrogen Catalysts: (1,2-Bis((R,R)-2,5-Diethyl-1-Phospholidinyl)Benzene)(1,5-Cyclooctadiene)Rhodium(... Solvents: Methanol,Ethyl Acetate; 12 H,40 Psi,Rt2.1 Reagents: Lithium Hydroxide Solvents: Methanol,Tetrahydrofuran,Water; 6 H,0 °C
标题:Discovery Of Pyrrolopyrimidine Inhibitors Of Akt
作者:Blake,James F.; Et Al
参考文献:Bioorganic & Medicinal Chemistry Letters 日期:2010 卷标:20(19) 页码:5607-5612]

89524-98-1 + 104-87-0 = 80102-27-8
反应条件:1.1 Reagents: 1,1,3,3-Tetramethylguanidine Solvents: Dichloromethane; 2 H,0 °C -> Rt2.1 Reagents: Hydrogen Catalysts: (1,2-Bis((R,R)-2,5-Diethyl-1-Phospholidinyl)Benzene)(1,5-Cyclooctadiene)Rhodium(... Solvents: Methanol,Ethyl Acetate; 12 H,40 Psi,Rt3.1 Reagents: Lithium Hydroxide Solvents: Methanol,Tetrahydrofuran,Water; 6 H,0 °C
标题:Discovery Of Pyrrolopyrimidine Inhibitors Of Akt
作者:Blake,James F.; Et Al
参考文献:Bioorganic & Medicinal Chemistry Letters 日期:2010 卷标:20(19) 页码:5607-5612

Methyl (R)-2-((Tert-Butoxycarbonyl)Amino)-3-(P-Tolyl)Propanoate置于水,Lithium Hydroxide体系中,用四氢呋喃,甲醇作为反应溶剂,化学反应 6.0H,反应生成 Boc-D-4-甲基苯丙氨酸
参考文献:Discovery Of Pyrrolopyrimidine Inhibitors Of Akt
标题:Discovery Of Pyrrolopyrimidine Inhibitors Of Akt
摘要:The Discovery And Optimization Of A Series Of Pyrrolopyrimidine Based Protein Kinase B (Pkb/akt) Inhibitors Discovered Via Hts And Structure Based Drug Design Is Reported. The Compounds Demonstrate Potent Inhibition Of All Three Akt Isoforms And Knockdown Of Phospho-Pras40 Levels In Lncap Cells And Tumor Xenografts. (C) 2010 Elsevier Ltd. All Rights Reserved.
DOI:10.1016/j.Bmcl.2010.08.053

海关参考信息

2902600000-乙苯
2905122000-异丙醇
2905143000-叔丁醇
2912110000-甲醛
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详情请参考：📖 海关编码查询和海关进出口税则

专利信息

专利号:EP-0412508-B1
优先权日:1989-08-07
标题:Analogues of vasopressin, their preparation and pharmaceutical use
发明人：PROCHAZKA ZDENKO; BLAHA IVO; ZERTOVA MIROSLAVA; SLANINOVA JIRINA; VELEK JIRI; SKOPKOVA JANA; LEBL MICHAL; BARTH TOMISLAV; MALETINSKA LENKA; VILHARDT HANS
权利人:CESKOSLOVENSKA AKADEMIE VED
摘要:The invention relates to analogues of 8-D-homoarginine-vasopressin of the general formula in which the meanings are: X L-O-methyltyrosine L-p-ethylphenylalanine D-p-ethylphenylalanine L-p-methylphenylalanine or D-p-methylphenylalanine and R cysteine or beta -mercaptopropionic acid to a process for the preparation thereof by solid-phase synthesis and to the pharmaceutical use thereof. The analogues of vasopressin have a selectively increased affinity for uterine oxytocin receptors, where they have an antagonistic action to oxytocin. The analogues of deaminovasopressin furthermore have a significantly reduced antidiuretic activity compared with [8-D-arginine]-deaminovasopressin.