CAS: 7159-36-6; Isoquinoline-4-Carboxylic Acid

该化合物是一种有机化合物,其特征是其同位素结构,由含有苯环和环的双环系统组成.该化合物的特点是在等离子环的四处放置一个碳苯基酸功能组(-COOH),有助于其酸性能.Isoquinoline-4-carboxylic酸通常是一种白色到白色的晶体状固体,它溶于水和酒精等极地溶剂,但非极溶剂的溶解性较小.该化合物对包括药用化学在内的各个领域具有兴趣,因为其潜在的生物活动,如抗微生物和抗炎特性.此外,它可以作为合成更复杂的分子的建筑块块.它的再活性受碳箱酸组的存在影响,该组可以参与各种化学反应,包括酯化和恐吓.

结构式图片

相似化合物

20317-40-2 34846-65-6 22960-16-3

欧盟法规

ECHA物质C&L通报

上下游产品

4-bromoisoquinoline isoquinoline-4-carbonitrile 4-lithioisoquinoline diethyl ether4-ethoxycarbonylisoquinoline methyl isoquinoline-4-carboxylate 4-(N-β-phenethylcarbamoyl)isoquinoline H-isoquinolin-2-yl)-acetic acid ethyl ester(4-phenethylcarbamoyl-1H-isoquinolin-2-yl)-acetic acid ethyl ester

合成工艺路线路线简述

    📜3-溴异喹啉置于四(三苯基膦)钯,水,Potassium Hydroxide体系中,用 乙醇,N,N-二甲基甲酰胺 作为反应溶剂,化学反应生成 4-异喹啉甲酸
    参考文献:Cannabinoid Receptor Modulators
    标题:Cannabinoid Receptor Modulators
    摘要:公式(i)的化合物以及用于制备这些化合物的方法,可用于治疗,管理和/或减轻与大麻素(cb)受体调节相关的疾病,紊乱,综合症或症状.治疗,管理和/或减轻与公式(i)的大麻素(cb)受体调节相关的疾病,紊乱,综合症或症状的方法.

    海关参考信息

    专利信息


    专利号:US-2004110228-A1
    优先权日:2002-04-01
    标 题:Combinatorial organic synthesis of unique biologically active compounds
    发明人:MCALPINE SHELLI R; TAYLOR RACHEL E; BOLLA MEGAN L; SEGALL ANCA M
    摘要:The invention provides a method for making a combinatorial library of cyclic compounds, such as Holliday junction-trapping compounds, comprising the steps of (a) obtaining a plurality of trimers according to the generic structure X 1- X 2- X 3 , wherein X 1 , X 2 and X 3 can be independently any naturally or nonnaturally occurring amino acids or peptidomimetics thereof; (b) optionally coupling a spacer S to the trimer at either end; (c) cyclizing two trimers or trimer-spacer conjugates in a head-to-tail orientation; thereby obtaining a combinatorial library of compounds, wherein the library does not include an unmodifed or naturally occurring Holliday Junction-trapping compounds. The invention additionally provides methods macrocyclic compounds that are synergimycin derivatives.

    专利号:US-5916899-A
    优先权日:1996-10-18
    标 题:Isoquinoline derivatives and isoquinoline combinatorial libraries
    发明人:KIELY JOHN S; GRIFFITH MICHAEL C
    权利人:TREGA BIOSCIENCES INC
    摘要:The present invention provides the synthesis of heterocyclic compounds based on the isoquinoline ring. More specifically, the invention provides novel isoquinolines as well as novel libraries comprised of many such compounds, and methods of synthesizing the libraries.

    专利号:US-6417195-B1
    优先权日:1999-02-22
    标题 :Isoquinoline derivatives and isoquinoline combinatorial libraries
    发明人:LEBL MICHAL
    权利人:LION BIOSCIENCE AG
    摘要:The present invention provides the synthesis of heterocyclic compounds based on the isoquinoline ring. More specifically, the invention provides novel isoquinoline derivatives as well as novel libraries comprised of such compounds.

    专利号:US-5874443-A
    优先权日:1995-10-19
    标 题:Isoquinoline derivatives and isoquinoline combinatorial libraries
    发明人:KIELY JOHN S; GRIFFITH MICHAEL C
    权利人:TREGA BIOSCIENCES INC
    摘要:The present invention provides the synthesis of heterocyclic compounds based on the isoquinoline ring. More specifically, the invention provides novel isoquinolines as well as novel libraries comprised of many such compounds, and methods of synthesizing the libraries.

    专利号:WO-0050406-A1
    优先权日:1999-02-22
    标 题 :Isoquinoline derivatives and isoquinoline combinatorial libraries
    发明人:LEBL MICHAEL
    权利人:TREGA BIOSCIENCES INC
    摘要:The present invention provides the synthesis of heterocyclic compounds based on the isoquinoline ring. More specifically, the invention provides novel isoquinoline derivatives as well as novel libraries comprised of such compouds.

    专利号:WO-2021045879-A1
    优先权日:2019-09-03
    标 题 :Synthesis of deuterated aldehydes

    供应商参考报价(招募中)

    品牌试剂参考报价(招募中)

    📌 第三方产品分析报告

    ✅ COA系统入驻 | 共享模式

    合成参考文献


    参考文献:10.1134/s1070363212040160
    摘要:Dyachenko IV, Vovk MV. Synthesis and transformations of new 3-oxo(thioxo)-1-phenyl-2,3,5,6,7,8-hexahydroisoquinoline-4-carboxylic acid derivatives. Russian Journal of General Chemistry. 2012 Apr;82(4):697–702. doi: 10.1134/s1070363212040160.
    参考文献:10.1007/7081_2012_92
    摘要:Chevallier F, Mongin F. Lithiations and Magnesiations on Quinoline and Isoquinoline. 2012. In: Metalation of Azines and Diazines. : Springer Berlin Heidelberg; 2012.
    📝 需求与反馈
    尽可能描述清楚需求与问题信息
    ×

    通知