CAS: 61150-59-2; 2-(2-Bromo-4-Fluorophenyl)Acetic Acid

上下游产品

CAS号61150-58-1 2-溴-4-氟苯乙腈 | CAS号1422-53-3 2-溴-4-氟甲苯 | CAS号61150-57-0 2-溴-4-氟溴苄

2-溴-4-氟苯乙腈置于双氧水,Sodium Hydroxide体系中,用 乙醇,水 作为反应溶剂,化学反应 24.0H,反应生成 2-溴-4-氟苯乙酸
参考文献:基于顺序氢化物移位/环化过程的手性二磷酸镁催化不对称双c(Sp3)-H键官能化
标题:基于顺序氢化物移位/环化过程的手性二磷酸镁催化不对称双c(Sp3)-H键官能化
摘要:本文描述的是手性二磷酸镁催化的不对称双 C(Sp3)-H 键官能化,由顺序氢化物移位/环化过程触发.该反应由立体选择性多米诺 C(Sp3)-H 键官能化组成:(1) 手性二磷酸镁的高度对映选择性和非对映选择性 C(Sp3)-H 键官能化(第一个 [1,5]-氢化物位移),和(2)通过非手性催化剂(yb(otf)3,第二个[1,5]-氢化物转移)进行高度非对映选择性的c(sp3)-H键官能化.
DOI:10.1021/jacs.8B02761

专利信息

专利号:US-8188113-B2
优先权日:2006-09-14
标 题 :Dihydropyridopyrimidinyl, dihydronaphthyidinyl and related compounds useful as kinase inhibitors for the treatment of proliferative diseases
发明人：FLYNN DANIEL L; PETILLO PETER A; KAUFMAN MICHAEL D; PATT WILLIAM C
权利人:FLYNN DANIEL L; PETILLO PETER A; KAUFMAN MICHAEL D; PATT WILLIAM C; DECIPHERA PHARMACEUTICALS INC
摘要:The present invention relates to novel dihydropyridopyrimidinyl, dihydronaphthyridinyl, and related compounds which are kinase inhibitors and modulator useful for the treatment of various diseases. More particularly, the invention is concerned with such compounds, kinase/compound adducts, methods of treating diseases, and methods of synthesis of the compounds. Preferably, the compounds are useful for the modulation of kinase activity of Raf kinases and disease polymorphs thereof. Compounds of the present invention find utility in the treatment of mammalian cancers and especially human cancers including but not limited to malignant melanoma, colorectal cancer, ovarian cancer, papillary thyroid carcinoma, non small cell lung cancer, and mesothelioma. Compounds of the present invention also find utility in the treatment of rheumatoid arthritis and retinopathies including diabetic retinal neuropathy and macular degeneration.