CAS: 6086-21-1; 1-Methyl-1,2,4-Triazole

该化合物是一种杂交有机化合物,其特点是五人环状结构,含有三个氮原子和两个碳原子;该化合物是三甲醇的衍生物,具体表现在环1位置的一组甲基;一般是一种无色的轻黄色液体或固态,视其形态和纯度而定;1-M乙基-1,2,4-三甲醇因其作为各种制药和农用化学协调体的建筑块的作用而闻名,因为它有能力协调化学及其潜在的生物活动;该化合物在水中表现出中等溶性,在有机溶剂中具有更大的溶性,使其具有多种用途;此外,在正常条件下保持稳定,但可能会发生典型的三硝酸化合物的反应,例如核生殖器替代物.安全数据表明,由于与接触相关的潜在健康危害,应当小心处理,因为许多化学物质.

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CAS号288-88-0 1,2,4-三氮唑 | CAS号74-88-4 碘甲烷 | CAS号74-83-9 溴甲烷 | CAS号21034-55-9 1-chloro-1,2,4-... | CAS号77-78-1 硫酸二甲酯 | CAS号290-87-9 1,3,5-三嗪 | CAS号817177-66-5 1H-1,2,4-三氮唑IUM... | CAS号39602-93-2 4-氨基-1-甲基-1,2,4... | CAS号584-13-4 4-氨基-1,2,4-三氮唑 | CAS号131758-17-3 2,2,2-TRICHLORO... | CAS号16681-72-4 5-溴-1-甲基-1,2,4-噻唑 | CAS号71597-10-9 5-(3,5-dimethox... | CAS号815588-93-3 1-甲基-1H-1,2,4-三... | CAS号4271-09-4 2,2-Bibenzothiazole

合成工艺路线路线简述

  • 合成目标产物 1-Methyl-1,2,4-Triazole 主要起始原料 1,2,4-Triazole And Dimethyl Carbonate
  • (文献来源)合成步骤主要原料 1,2,4-Triazole 和 Dimethyl Carbonate
1H-1,2,4-三氮唑ium,4-氨基-1-甲基-硝酸盐 反应生成 1-甲基-1,2,4-三唑
参考文献:Confined Rapid Thermolysis/ftir/tof Studies Of Methyl-Amino-Triazolium-Based Energetic Ionic Liquids
标题:Confined Rapid Thermolysis/ftir/tof Studies Of Methyl-Amino-Triazolium-Based Energetic Ionic Liquids
摘要:Thermal Decomposition Of The Energetic Ionic Liquids 1-Methyl-4-Amino-1,2,4-Triazolium Iodide (Me4Ati),1-Methyl-4-Amino-1,2,4-Triazolium Nitrate (Me4Atn),1-Amino-3-Methyl-1,2,3-Triazolium Iodide (Me1Ati),And 1-Amino-3-Methyl-1,2,3-Triazolium Nitrate (Me1Atn) Was Studied By Confined Rapid Thermolysis. Sub-Milligram Quantities Of The Compounds Were Subjected To Decomposition Under Isothermal Conditions Achieved By Initially Heating The Sample At Rates Of Approximately 2000 K/s. The Products Formed By Decomposition Under The Afore-Mentioned Conditions Were Sampled By Rapid Scan Ftir Spectroscopy And Time-Of-Flight Mass Spectrometry. Decomposition Studies Involving The Iodide Salts Were Carried Out Around 270-290 Degrees C,Whereas The Nitrate Salts Were Subjected To 320-340 Degrees C. The Amino Group Was Found To Be Involved In The Initiation Reaction,Forming Copious Quantities Of Ammonia From The Iodide Compounds And,N2O And H2O From The Nitrate Compounds. The Extent Of Decomposition Of The Triazole Ring Was Minimal At The Considered Temperatures. (C) 2010 Elsevier B.V. All Rights Reserved.
DOI:10.1016/j.Tca.2010.03.022

专利信息


专利号:US-9755163-B2
优先权日:2010-04-30
标 题:Synthesis of four coordinated palladium complexes and their applications in light emitting devices thereof
发明人:LI JIAN; TURNER ERIC
权利人:ARIZONA BOARD OF REGENTS ACTING FOR AND ON BEHALF OF ARIZONA STATE UNIV; ARIZONA BOARD OF REGENTS ACTING FOR OR ON BEHALF OF ARIZONA STATE UNIV
摘要:Synthesis of four coordinated palladium complexes and their applications in light emitting devices thereof.

专利号:US-9126995-B2
优先权日:2011-11-08
标题:Method for catalytic asymmetric synthesis of optically active isoxazoline compound and optically active isoxazoline compound
发明人:TOYAMA KEN-ICHI; MORIYAMA YUJI; MATOBA KAZUTAKA; YAOSAKA MANABU; IKEDA EITATSU
权利人:NISSAN CHEMICAL IND LTD
摘要:There is provided a method for catalytic asymmetric synthesis of optically active isoxazoline compound and an optically active isoxazoline compound. A method for catalytic asymmetric synthesis of optically active isoxazoline compound of a formula (6) including reacting an α,β-unsaturated carbonyl compound of a formula (1) and a hydroxylamine in a solvent in the presence of a base by adding a chiral phase transfer catalyst. An optically active isoxazoline compound of a formula (13) that can be synthesized by the method.

专利号:US-2020047146-A1
优先权日:2017-03-17
标 题 :Hydroxyalkylated polyacrylamide surface coatings for in situ synthesis of dna arrays
发明人:MCGALL GLENN
权利人:CENTRILLON TECH HOLDINGS CORPORATION
摘要:The present disclosure relates to processes for derivatizing a surface of a substrate with a covalently bonded thin film of hydroxalkylated poly(acrylamide) as a platform for the synthesis of a biomolecule array. These processes can also be used to prepare a surface of a substrate for an in situ solid-phase synthesis of biomolecule array.

专利号:US-2016280691-A1
优先权日:2013-11-07
标 题 :Triazole intermediates useful in the synthesis of protected n-alkyltriazolecarbaldehydes
发明人:HENDERSON MARK
权利人:BIOMARIN PHARM INC
摘要:Described herein are compounds and methods of making such compounds useful in the synthesis of protected N-alkyl-triazolecarbaldehydes.

专利号:US-9324957-B2
优先权日:2010-04-30
标 题:Synthesis of four coordinated gold complexes and their applications in light emitting devices thereof
发明人:LI JIAN; TUMER ERIC
权利人:LI JIAN; TUMER ERIC; UNIV ARIZONA STATE
摘要:Synthesis of four coordinated gold complexes and their applications in light emitting devices thereof.

专利号:US-7786156-B2
优先权日:2004-01-28
标 题 :Synthesis methods and intermediates for the manufacture of Rizatriptan
发明人:MARTIN PIERRE; BERENS ULRICH; BOUDIER ANDREAS; DOSENBACH OLIVER
权利人:RATIOPHARM GMBH
摘要:The invention relates to a process for the manufacture of an 1,2,4-triazol-1-yl compound of the formula [A], n nor a salt thereof, wherein each of R3 and R4 is hydrogen or lower alkyl, said process comprising reacting a hydrazine compound of the formula [B]n n nwherein R is hydrogen or acyl, R2 is hydrogen or a protecting group, are hydrogen or lower alkyl, and R6 is hydrogen or COOR7, or a salt thereof, with a 1,2,4-triazolyl forming reagent.n n In addition, novel intermediates for the synthesis of the anti-migraine agent Rizatriptan and methods for their synthesis are presented.
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合成参考文献


摘要:Gondo, C. A.; Bode, J. W., Science of Synthesis Knowledge Updates, (2012) 2, 210.
摘要:Huynh, H. V.; Yuan, D., Science of Synthesis: N-Heterocyclic Carbenes in Catalytic Organic Synthesis, (2016) 1, 19.
摘要:L.I. Bagal, M.S. Pevzner and V.A. Lopyrev. Khim. Geterotsikl. Soedin., Akad. Nauk Latv. SSSR 1966,440; CA 675, 12204h.
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